2-氨基环戊基甲胺 | 21544-02-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氨基环戊基甲胺
• 中文别名: 2-氨基环戊烷甲基胺
• 英文名称: 2-(aminomethyl)-cyclopentylamine
• 英文别名: 2-(aminomethyl)cyclopentylamine；2-aminomethylcyclopentylamine；2-aminomethyl-cyclopentylamine；2-Amino-1-aminomethyl-cyclopentan；2-Aminomethyl-cyclopentylamin；2-(aminomethyl)-1-cyclopentylamine；2-Aminocyclopentanemethylamine；2-(aminomethyl)cyclopentan-1-amine
• CAS: 21544-02-5
• 化学式: C₆H₁₄N₂
• mdl: MFCD00127789
• 分子量: 114.191
• InChiKey: SRGQQZYVZFJYHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  87-88 °C(Press: 18 Torr)
• 密度：
  0.961 g/cm3(Temp: 17 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2921300090

反应信息

• 作为反应物：
  描述：

  2-氨基环戊基甲胺 在 吡啶 、 磺酰胺 作用下， 生成 octahydro-cyclopenta[1,2,6]thiadiazine 2,2-dioxide
  参考文献：
  名称：

  Arya,V.P.; Shenoy,S.J., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1976, vol. 14, p. 766 - 769

  摘要：

  DOI：
• 作为产物：
  描述：

  2-亚氨基环戊烷-1-甲腈 在 lithium aluminium tetrahydride 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 4.25h， 生成 2-氨基环戊基甲胺
  参考文献：
  名称：

  Syntheses and Biological Activities of Octahydro-1H-cyclopenta[d]pyrimidine Derivatives

  摘要：

  Various nitromethylene derivatives were synthesized regioselectively. Compounds 8a-f were obtained by the reaction of 1-((5-chloropyridin-2-yl)methyl)-2-(nitromethylene)-octahydro-1H-cyclopenta[d]pyrimidine (3) with primary amines and formaldehyde. The synthesized compounds were identified by H-1 NMR, HRMS (EI), and IR, and preliminary bioassays indicated that most of them showed moderate insecticidal activities against Aphis craccivora. The relationship between hydrophobicity and biological activity was also discussed.

  DOI：

  10.1021/jf062845l

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别含有羧酸酯或磷酸酯基团取代的抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶对这类化合物库进行筛选。还提供了与GS-7340酯水解酶相关的组合物和方法。
• Quinolones used as MRS inhibitors and bactericides
  申请人：SmithKline Beecham plc

  公开号：US06320051B1

  公开（公告）日：2001-11-20

  Compounds of formula (I) are inhibitors of the bacterial enzyme S aureus methionyl tRNA synthetase and are of use in treating bacterial infections.

  化合物的化学式（I）是细菌酶S aureus甲硫氨酰tRNA合成酶的抑制剂，并可用于治疗细菌感染。
• Separation of 6-aminocapronitrile and hexamethylenediamine from a mixture comprising hexamethylenediamine, 6-aminocapronitrile and tetrahydroazepine
  申请人：Ostermaier J. John

  公开号：US20060058545A1

  公开（公告）日：2006-03-16

  The invention relates to the field of separation by distillation of 6-aminocapronitrile (ACN) and hexamethylenediamine (HMD) from a mixture comprising ACN, HMD, tetrahydrozaepine (THA), adiponitrile (ADN) and low boilers (LB). A method for producing a distillate stream comprising HMD is disclosed, which is suitable for the production of Nylon-6,6. The tails stream from the distillation of the mixture can be further distilled to produce a distillate comprising ACN and THA, which is particularly suitable for use in the production of caprolactam and Nylon-6 from the caprolactam. Process conditions of the method of the invention disfavor the production of 2-cyanocyclopentylideneirnine (CPI).

  该发明涉及从包含ACN、HMD、THA、ADN和低沸点物（LB）的混合物中，通过蒸馏分离6-氨基己腈（ACN）和六亚甲基二胺（HMD）的领域。公开了一种用于生产包含HMD的蒸馏流的方法，适用于生产尼龙-6,6。混合物蒸馏的尾流可以进一步蒸馏以生产包含ACN和THA的蒸馏物，特别适用于用于从己内酰胺生产己内酰胺和尼龙-6。该发明方法的工艺条件不利于生产2-氰基环戊基亚胺（CPI）。
• METHOD FOR PRODUCING HEXAMETHYLENEDIAMINE
  申请人：BASF SE

  公开号：US20160326092A1

  公开（公告）日：2016-11-10

  The invention relates to a method for producing hexamethylenediamine, wherein a) a muconic acid starting material is provided, which is selected from among muconic acid, esters of muconic acid, lactones of muconic acid, and mixtures thereof, b) the muconic acid starting material is subjected to a reaction with hydrogen in the presence of at least one hydrogenation catalyst in order to form 1,6-hexanediol, and c) the 1,6-hexanediol obtained in step b) is subjected to amination in the presence of an amination catalyst in order to obtain hexamethylenediamine. The invention further relates to hexamethylenediamine which can be produced by means of said method.

  该发明涉及一种生产己二胺的方法，其中a)提供一种顺丁二酸起始原料，所述顺丁二酸起始原料被选自顺丁二酸、顺丁二酸酯、顺丁二酸内酯及其混合物之一，b)在至少一种加氢催化剂的存在下，将所述顺丁二酸起始原料与氢气反应，以形成1,6-己二醇，c)将步骤b)中获得的1,6-己二醇在氨化催化剂的存在下进行氨化，以获得己二胺。该发明还涉及通过该方法生产的己二胺。
• Low pressure process for the manufacture of 2-(aminomethyl)-1-cyclopentylamine
  申请人：——

  公开号：US20040249214A1

  公开（公告）日：2004-12-09

  Disclosed herein is a process for the manufacture of 2-(aminomethyl)-1-cyclopentylamine by low-pressure hydrogenation of 1-amino-2-cyano-1-cyclopentene using a combination catalyst system of nickel with palladium on carbon, or a single palladium-doped Raney-type catalyst.

  本文披露了一种制备2-(氨甲基)-1-环戊胺的方法，该方法通过在低压下使用镍与钯载体碳或单一钯掺杂的雷尼型催化剂的组合催化系统对1-氨基-2-氰基-1-环戊烯进行加氢实现。