N-phenylphosphazoanilide | 5679-59-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-phenylphosphazoanilide
• 英文别名: N-Phenylamino-N'-phenylimino-phosphin；Phenylphosphazoanilid；diphenylphosphazoanilide；phenylphosphenimidous acid anilide cyclooligomers；Phosphenimidous amide, n,n'-diphenyl-；N-phenyliminophosphanylaniline
• CAS: 5679-59-4
• 化学式: C₁₂H₁₁N₂P
• 分子量: 214.207
• InChiKey: ZZRVACZASGFDFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-phenylphosphazoanilide 、 2-羟基-3-甲基丁酸 以 甲苯 为溶剂， 生成 N-phenyl-2-hydroxy-3-methyl-butanamide
  参考文献：
  名称：

  Schroeder,E.; Luebke,K., Justus Liebigs Annalen der Chemie, 1962, vol. 655, p. 211 - 218

  摘要：

  DOI：
• 作为产物：
  描述：

  苯胺 在 三氯化磷 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 N-phenylphosphazoanilide
  参考文献：
  名称：

  磷酸从丙烯酸及其衍生物制取2-烯酰胺的途径

  摘要：

  通过由脂肪族，脂环族和芳香族伯胺发出的原位生成的膦偶氮化合物与丙烯酸及其衍生物的反应，可以形成高分离度的2-烯酰胺（通常最高可达70％）。

  DOI：

  10.1016/s0040-4039(00)88859-0

文献信息

• The phosphazo route to 2-alkenamides from acrylic acid and its derivatives
  作者：José Cabral、Pierre Laszlo、Marie-Thérèse Montaufier、S Lalatiana Randriamahefa

  DOI：10.1016/s0040-4039(00)88859-0

  日期：1990.1

  2-Alkenamides are formed in good isolated yields (generally up to 70%) by the reaction of in situ-generated phosphazo compounds issued from aliphatic, alicyclic and aromatic primary amines, with acrylic acid and its derivatives.

  通过由脂肪族，脂环族和芳香族伯胺发出的原位生成的膦偶氮化合物与丙烯酸及其衍生物的反应，可以形成高分离度的2-烯酰胺（通常最高可达70％）。
• Synthesis and Crystal Structure of 3-Methyl-4-phenyl-5-(2-pyridyl)-1,2,4-triazole
  作者：Chunyi Liu、Zuoxiang Wang、Hailian Xiao、Yan Lan、Xiaomin Li、Songpei Wang、Jie Tang、Zhengping Chen

  DOI：10.1007/s10870-009-9583-3

  日期：2009.12

  The title compound, 3-methyl-4-phenyl-5-(2-pyridyl)-1,2,4-triazole was synthesized by reaction of diphenylphosphazoanilide with N-acetyl-N′-(2-pyridoyl)hydrazine. Crystals suitable for X-ray analysis were obtained from a mixed solution of water and ethanol in a one-to-one volume ratio. The crystal is orthorhombic, space group P212121 with crystallographic parameters: a = 19.414(4) Å, b = 17.172(3) Å, c = 7.4850(15) Å, β = 90.00°, μ = 0.079 mm−1, V = 2495.3(8) Å3, Z = 8, Dc = 1.258 g/cm3, F(000) = 992, T = 295(2) K. The X-ray results showed that in the crystal structure of the title compound, the 1,2,4-triazole, pyridine and benzene rings are not coplanar. The title compound was synthesized by reaction of diphenylphosphazoanilide with N-acetyl-N′-(2-pyridoyl)hydrazine, and the crystal structure shows that its three aromatic rings (1,2,4-triazole, pyridine and benzene rings) do not share a common plane.

  标题化合物3-甲基-4-苯基-5-(2-吡啶基)-1,2,4-三唑是通过二苯基磷酰苯胺与N-乙酰基-N′-(2-吡啶基)肼反应合成的。从水和乙醇的混合溶液（体积比为1:1）中获得了适合X射线分析的晶体。晶体为正交晶系，空间群为P212121，晶体学参数为：a=19.414(4)Å，b=17.172(3)Å，c=7.4850(15)Å，β=90.00°，μ=0.079mm-1，V=2495.3(8)Å3，Z=8，Dc=1.258g/cm3，F(000)=992，T=295(2)K。X射线结果表明，在标题化合物的晶体结构中，1,2,4-三唑、吡啶和苯环不共面。标题化合物是通过二苯基磷酰苯胺与N-乙酰基-N′-(2-吡啶基)肼反应合成的，晶体结构显示其三个
• Lampin,J.-P. et al., Bulletin de la Societe Chimique de France, 1972, p. 3494 - 3502
  作者：Lampin,J.-P. et al.

  DOI：——

  日期：——
• An efficient route to vinyl substituted oxadiazoles and triazoles using phenylselanyl derivatives as precursor
  作者：Yu-Guang Wang、Xian Huang、Yu-Zhou Wu

  DOI：10.1016/j.tet.2007.05.080

  日期：2007.8

  Vinyl substituted oxadiazoles and triazoles were obtained from selenoxide syn-elimination of phenylselanylethyl substituted oxadiazoles and triazoles, which were prepared through hydrazinolysis, acylation, and cyclocondensation reactions of phenylselanyl-propionate. Using phenylselanyl group as the precursor of terminal double bond is critical to the success of the reactions. (C) 2007 Elsevier Ltd. All rights reserved.
• Novel Approach for the Synthesis of<i>N</i>-Substituted-4-(2-methyl-4-oxo-4<i>H</i>-quinazolin-3-yl)-butyramides
  作者：Mohammad Amir、Israr Ali

  DOI：10.1080/00397911.2010.497594

  日期：2011.7.15

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

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