2-o-Aminophenyl-4-phenylthiazole | 70031-68-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-o-Aminophenyl-4-phenylthiazole
• 英文别名: 2-(4-phenylthiazole-2-yl)aniline；2-(4-Phenylthiazol-2-yl)aniline；2-(4-phenyl-1,3-thiazol-2-yl)aniline
• CAS: 70031-68-4
• 化学式: C₁₅H₁₂N₂S
• mdl: MFCD16241763
• 分子量: 252.34
• InChiKey: PYGAMZBHQDEFJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  67.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-o-Aminophenyl-4-phenylthiazole 在 高氯酸 作用下， 以 甲醇 为溶剂， 生成 2-(4-Phenyl-thiazol-2-yl)-phenylamine; compound with perchloric acid
  参考文献：
  名称：

  Singh, Harjit; Gandhi, C. S.; Bal, M. S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1981, vol. 20, # 1, p. 17 - 20

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-nitrophenyl)-4-phenylthiazole 在 镍 氢气 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以to give 2-(4-phenylthiazol-2-yl)aniline as a yellow solid (2.3 g, 86% yield)的产率得到2-o-Aminophenyl-4-phenylthiazole
  参考文献：
  名称：

  AMIDE DERIVATIVES AS SIRTUIN MODULATORS

  摘要：

  本文提供了由结构式（I）所代表的新型sirtuin调节化合物及其使用方法。这些sirtuin调节化合物可用于增加细胞寿命，并治疗和/或预防各种疾病和障碍，包括与衰老或压力有关的疾病或障碍、糖尿病、肥胖症、神经退行性疾病、心血管疾病、血液凝固障碍、炎症、癌症和/或潮红症，以及需要增加线粒体活性的疾病或障碍。此外，还提供了含有sirtuin调节化合物与另一种治疗剂的组合物。

  公开号：

  US20110039847A1

文献信息

• [EN] AMIDE DERIVATIVES AS SIRTUIN MODULATORS<br/>[FR] DÉRIVÉS D'AMIDE COMME MODULATEURS DE SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2009058348A1

  公开（公告）日：2009-05-07

  Provided herein are novel sirtuin-modulating compounds represented by Structural Formula (I) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin- modulating compound in combination with another therapeutic agent.

  提供的是由结构公式（I）表示的新的sirtuin调节化合物及其用途。sirtuin调节化合物可用于延长细胞寿命，以及治疗和/或预防多种疾病和紊乱，例如与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、凝血障碍、炎症、癌症和/或潮红相关的疾病或紊乱，以及将从增加线粒体活性中受益的疾病或紊乱。还提供了包含sirtuin调节化合物与另一种治疗剂的组合的药物组合物。
• M3muscarinic acetylcholine receptor antagonists
  申请人：Laine I. Dramane

  公开号：US20050277676A1

  公开（公告）日：2005-12-15

  M 3 Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.

  本文提供了M3型肌肉型乙酰胆碱受体拮抗剂及其使用方法。
• Thiazole-based chemosensor III: synthesis and fluorescence sensing of CH3CO2− based on inhibition of ESIPT
  作者：Aasif Helal、Hong-Seok Kim

  DOI：10.1016/j.tet.2010.07.007

  日期：2010.8

  Novel fluorogenic sensors based on urea derivative of 2-(2'-aminophenyl)-4-phenylthiazole (4 and 5) were prepared and used for recognition of anions with similar basicity and surface charge density. Chemosensor 4 was found to be highly selective to acetate ion over other anions. The selectivity was related to the structure matching between the host and the guest. The evaluation of the chemosensors' interaction with anions was performed by UV-vis and fluorescence titration. This acetate binding affinity was further tuned by varying the acidity of the N-H proton of the urea moiety in chemosensor 5. (C) 2010 Elsevier Ltd. All rights reserved.
• Singh, Harjit; Aggarwal, Sunil K.; Malhotra, Nageshwar, Heterocycles, 1983, vol. 20, # 6, p. 983 - 984
  作者：Singh, Harjit、Aggarwal, Sunil K.、Malhotra, Nageshwar

  DOI：——

  日期：——
• Thiazole sulfonamide based ratiometric fluorescent chemosensor with a large spectral shift for zinc sensing
  作者：Aasif Helal、Sang Hyun Kim、Hong-Seok Kim

  DOI：10.1016/j.tet.2010.10.055

  日期：2010.12

  Anew thiazole sulfonamide (TIP, 1) based Zn2+ selective intrinsic chemosensor has been synthesized and investigated. The chemosensor shows a selective fluorescence enhancement (3.0 fold) with Zn2+ over biologically relevant cations (Ca2+, Mg2+, Na+, and K+) and biologically non-relevant cations (Cd2+) in an aqueous ethanol system. It produces an increase in the quantum yield and a longer emission wavelength shift (64 nm) on Zn2+ binding with the potential of a ratiometric assay. (C) 2010 Elsevier Ltd. All rights reserved.