2-氯-1-甲基吡啶鎓 | 45528-84-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氯-1-甲基吡啶鎓
• 英文名称: 2-Chlor-1-methylpyridinium
• 英文别名: 2-Chlor-N-methylpyridinium；1-Methyl-2-chlor-pyridinium；2-Chloro-1-methylpyridinium；2-chloro-1-methylpyridin-1-ium
• CAS: 45528-84-5
• 化学式: C₆H₇ClN
• 分子量: 128.581
• InChiKey: ZNPNOVHKCAAQCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-氯-1-甲基吡啶鎓 在 水 作用下， 生成 1-甲基-2-吡啶酮
  参考文献：
  名称：

  Accelerated hydrolysis of α-halo and α-cyano pyridinium relative to uracil derivatives: a model for ODCase-catalyzed hydrolysis of 6-cyanoUMP

  摘要：

  alpha-Halo and alpha-cyano pyridiniums were found to undergo facile hydrolysis, in contrast to the sluggish reactions of corresponding uracils. The greatly enhanced rates found with pyridinium compounds have indicated a possible source of the rate acceleration seen in the hydrolysis of 6-cyanouridine 5'-monophosphate catalyzed by orotidine 5'-monophosphate decarboxylase. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.05.108
• 作为试剂：
  描述：

  2-巯基噻唑啉 、 11,11'-(2,7-fluorenyl)-bis-10-undecynoic acid 在 2-氯-1-甲基吡啶鎓 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以54%的产率得到3,3'-<11,11'-(2,7-fluorenyl)-bis-10-undecynoyl>-bis-thiazolidine-2-thione
  参考文献：
  名称：

  Synthesis of two new phospholipidic fluorescent probes for membrane studies

  摘要：

  Two new fluorenyl-phospholipidic probes have been prepared in good yield by a Pd-0/CuI-catalyzed cross-coupling reaction.

  DOI：

  10.1016/0040-4020(95)00011-v

文献信息

• Preparation of Mono-/Difluorinated Hydrocarbon Compounds
  申请人：Saint-Jalmes Laurent

  公开号：US20090234151A1

  公开（公告）日：2009-09-17

  Mono- or difluorinated hydrocarbon compounds are prepared from an alcohol or a carbonylated compound by reacting one of these with a fluorinating reagent, optionally in the presence of a base, the fluorinating agent comprising a pyridinium reactant having the following formula (F), wherein R 0 is an alkyl or cycloalkyl radical:

  从醇或羰基化合物中制备单氟或二氟烃化合物，通过将其中一种与氟化试剂反应制备，可选地在碱的存在下，氟化剂包括具有以下公式（F）的吡啶反应物，其中R0是烷基或环烷基基团。
• [EN] TRICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM<br/>[FR] NUCLÉOSIDES TRICYCLIQUES ET COMPOSÉS OLIGOMÈRES PRÉPARÉS À PARTIR DE CEUX-CI
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2013154799A1

  公开（公告）日：2013-10-17

  The present disclosure provides tricyclic nucleosides and oligomeric compounds prepared therefrom. More particularly, the tricyclic nucleosides provided herein comprise a tricyclic ribosyl sugar moiety having a bridge between the 4' and 2' ring carbon atoms and a further fused carbocyclic or heterocyclic ring at the 3' and 4' carbon atoms. The tricyclic nucleosides are expected to be useful for enhancing properties of oligomeric compounds including for example binding affinity and nuclease resistance.

  本公开提供了三环核苷和由此制备的寡聚化合物。更具体地，本文提供的三环核苷包括具有在4'和2'环碳原子之间的桥的三环核糖糖基，并且在3'和4'碳原子处具有进一步融合的碳环或杂环。预计这些三环核苷对增强寡聚化合物的性质（例如结合亲和力和核酸酶抗性）将会有用。
• PROCESS FOR THE PREPARATION OF VILAZODONE HYDROCHLORIDE AND ITS AMORPHOUS FORM
  申请人：ALEMBIC PHARMACEUTICALS LIMITED

  公开号：US20150087835A1

  公开（公告）日：2015-03-26

  The present invention relates to an improved process for the preparation of vilazodone Hydrochloride and a process for preparation of novel pure amorphous form of vilazodone hydrochloride.

  本发明涉及一种改进的维拉唑酮盐酸盐制备工艺，以及一种制备新型纯非晶态维拉唑酮盐酸盐的工艺。
• [EN] CHOLESTEROL/BILE ACID/BILE ACID DERIVATIVE-MODIFIED THERAPEUTIC ANTI-CANCER DRUGS<br/>[FR] MEDICAMENTS ANTICANCEREUX THERAPEUTIQUES MODIFIES PAR LE CHOLESTEROL/L'ACIDE BILIAIRE/LES DERIVES D'ACIDE BILIAIRE
  申请人：SONUS PHARMA INC

  公开号：WO2005118612A1

  公开（公告）日：2005-12-15

  Cholesterol-modified anti-cancer therapeutic drug compounds, bile-acid-modified anti-cancer therapeutic drug compounds, and bile-acid-derivative-modified anti-cancer therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds, methods for administering the compounds and formulations; and methods for treating cancer using the compounds and formulations.

  胆固醇修饰的抗癌治疗药物化合物，胆酸修饰的抗癌治疗药物化合物，以及胆酸衍生物修饰的抗癌治疗药物化合物；包括这些化合物的乳剂、微乳剂和胶束配方，用于给药这些化合物和配方的方法；以及使用这些化合物和配方治疗癌症的方法。
• LIPOPHILIC ANTICANCER DRUG COMPOUNDS, COMPOSITIONS AND RELATED METHODS
  申请人：Zhang Yuehua

  公开号：US20070142331A1

  公开（公告）日：2007-06-21

  Lipophilic anticancer drug compounds, compositions that include the compounds, and methods for treating a cell proliferative disease using the compounds.

  亲脂性抗癌药物化合物，包括该化合物的组合物，以及使用该化合物治疗细胞增殖性疾病的方法。