3-phenypropynoic acid cyclopent-1-enyl-(2,2-dimethyl-propyl)-amide | 1042036-29-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenypropynoic acid cyclopent-1-enyl-(2,2-dimethyl-propyl)-amide
• 英文别名: N-(cyclopenten-1-yl)-N-(2,2-dimethylpropyl)-3-phenylprop-2-ynamide
• CAS: 1042036-29-2
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: CQVDQHKCGVGSDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-phenypropynoic acid cyclopent-1-enyl-(2,2-dimethyl-propyl)-amide 在 silver tetrafluoroborate 、 [Au(Cl)PPh₃] 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以91%的产率得到1-(2,2-dimethylpropyl)-4-phenyl-1,5,6,7-tetrahydro-[1]pyrindin-2-one
  参考文献：
  名称：

  Convergent and Rapid Assembly of Substituted 2-Pyridones through Formation of N-Alkenyl Alkynylamides Followed by Gold-Catalyzed Cycloisomerization

  摘要：

  A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed cycloisomerization.

  DOI：

  10.1021/ol801466f
• 作为产物：
  描述：

  phenylpropiolyl chloride 、 N-(2,2-dimethylpropyl)cyclopentanimine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以72%的产率得到3-phenypropynoic acid cyclopent-1-enyl-(2,2-dimethyl-propyl)-amide
  参考文献：
  名称：

  Convergent and Rapid Assembly of Substituted 2-Pyridones through Formation of N-Alkenyl Alkynylamides Followed by Gold-Catalyzed Cycloisomerization

  摘要：

  A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed cycloisomerization.

  DOI：

  10.1021/ol801466f

文献信息

• Convergent and Rapid Assembly of Substituted 2-Pyridones through Formation of <i>N</i>-Alkenyl Alkynylamides Followed by Gold-Catalyzed Cycloisomerization
  作者：Hidetomo Imase、Keiichi Noguchi、Masao Hirano、Ken Tanaka

  DOI：10.1021/ol801466f

  日期：2008.8.21

  A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh3-catalyzed cycloisomerization.