A 31125 | 82935-41-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: A 31125
• 英文别名: N-((1-ethylpyrrolidin-2-yl)methyl)-2,6-dimethoxybenzamide；N-[(1-ethylpyrrolidin-2-yl)methyl]-2,6-dimethoxybenzamide
• CAS: 82935-41-9
• 化学式: C₁₆H₂₄N₂O₃
• 分子量: 292.378
• InChiKey: XHDCLFMAXFUNGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二甲氧基苯甲酸 在 氯化亚砜 作用下， 以 甲苯 、 丁酮 为溶剂， 反应 1.0h， 生成 A 31125
  参考文献：
  名称：

  Potential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities

  摘要：

  A series of some novel N-(l-ethyl-2-pyrrolidinylmethyl)benzamides was synthesized and tested for dopamine receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00353a003

文献信息

• RADIOTRACER PRECURSOR AND METHOD FOR PREPARING THE SAME
  申请人：LIU SHOW-WEN

  公开号：US20140073803A1

  公开（公告）日：2014-03-13

  A precursor SnBZM for a dopamine receptor radiotracer and a method for preparing the same are revealed. The precursor includes a tributyltin group (Bu 3 Sn) that is easy to be replaced. Thus a dopamine receptor radiotracer 123 I-IBZM can be produced at high yield rate by a substitution reaction of the precursor. At the same time, both the method for preparing the precursor SnBZM and a method for preparing a reference standard IBZM are simplified. Moreover, stability of each product is improved.

  揭示了一种用于多巴胺受体放射示踪剂的前体SnBZM以及制备该前体的方法。该前体包括一个易于被替换的三丁基锡基团（Bu3Sn）。因此，通过对前体的取代反应，可以高产率地生产多巴胺受体放射示踪剂123I-IBZM。同时，简化了制备前体SnBZM和制备参比标准IBZM的方法。此外，提高了每个产品的稳定性。
• US8877943B2
  申请人：——

  公开号：US8877943B2

  公开（公告）日：2014-11-04
• Potential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities
  作者：Lennart Florvall、Sven Ove Oegren

  DOI：10.1021/jm00353a003

  日期：1982.11

  A series of some novel N-(l-ethyl-2-pyrrolidinylmethyl)benzamides was synthesized and tested for dopamine receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. The structure-activity relationships are discussed.

表征谱图