5-(5'-chloro-2'-methoxyphenyl)imidazolidine-2,4-dione | 120121-09-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-(5'-chloro-2'-methoxyphenyl)imidazolidine-2,4-dione
• 英文别名: 5-(5-Chloro-2-methoxyphenyl)imidazolidine-2,4-dione
• CAS: 120121-09-7
• 化学式: C₁₀H₉ClN₂O₃
• 分子量: 240.646
• InChiKey: OCWYMCUTPQGMIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氯-2-甲氧基苯乙酮 、 氰化钾 以32%的产率得到
  参考文献：
  名称：

  SARGES, REINHARD;SCHNUR, RODNEY C.;BELLETIRE, JOHN L.;PETERSON, MICHAEL J+, J. MED. CHEM., 31,(1988) N 1, 230-243

  摘要：

  DOI：

文献信息

• ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP3838898A1

  公开（公告）日：2021-06-23

  The present invention relates to an isoindolin-1-one derivative, a method for preparing the same, and a pharmaceutical composition comprising the same as an active ingredient for preventing or treating cancer, wherein the isoindolin-1-one derivative exhibits a high inhibitory effect on EGFR mutations, and thus can be beneficially used for the treatment of EGFR-mutated cancers, and the isoindolin-1-one derivative exhibits a significant synergistic effect when co-administered, and thus can be beneficially used in concomitant therapy.

  本发明涉及一种异吲哚啉-1-酮衍生物、制备该衍生物的方法以及一种包含该衍生物作为活性成分的药物组合物，用于预防或治疗癌症，其中异吲哚啉-1-酮衍生物对表皮生长因子受体突变具有较高的抑制作用，因此可用于治疗表皮生长因子受体突变的癌症，并且该异吲哚啉-1-酮衍生物在联合用药时具有显著的增效作用，因此可用于联合治疗。
• Rotationally restricted mimics of rigid molecules: nonspirocyclic hydantoin aldose reductase inhibitors
  作者：James P. Rizzi、Rodney C. Schnur、Nancy J. Hutson、Kenneth G. Kraus、Paul R. Kelbaugh

  DOI：10.1021/jm00126a011

  日期：1989.6

  Sorbinil (1), a spirocyclic hydantoin, is a potent inhibitor of the enzyme aldose reductase. Simulation of the rigid spirocyclic ring orientation found in sorbinil was achieved with nonspirocyclic 5-[5'-chloro-2'-(alkylsulfonyl)-phenyl]hydantoins and 5-[5'-chloro-2'-[(N-alkylamino)sulfonyl]phenyl]hydantoins. The 2'-substituent (SO2R) was sufficiently large to hinder rotation of the hydantoin ring, forcing an orientation similar to that of a spirocyclic hydantoin. Calculated conformational preference, X-ray data, and inhibitory IC50 values for these nonspirocyclic 2'-substituted (SO2R) phenylhydantoins are in accord with what is expected for spirocyclic hydantoins and comparable to those of sorbinil.
• SARGES, REINHARD;SCHNUR, RODNEY C.;BELLETIRE, JOHN L.;PETERSON, MICHAEL J+, J. MED. CHEM., 31,(1988) N 1, 230-243
  作者：SARGES, REINHARD、SCHNUR, RODNEY C.、BELLETIRE, JOHN L.、PETERSON, MICHAEL J+

  DOI：——

  日期：——
• [EN] ISOINDOLIN-1-ON DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS EFFECTIVE COMPONENT FOR PREVENTING OR TREATING CANCER<br/>[FR] DÉRIVÉ D'ISOINDOLIN-1-ONE, PROCÉDÉ DE PRÉPARATION DE CELUI-CI, ET COMPOSITION PHARMACEUTIQUE LE CONTENANT EN TANT QUE COMPOSANT ACTIF POUR LA PRÉVENTION OU LE TRAITEMENT DU CANCER<br/>[KO] 이소인돌린-1온 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물
  申请人：KOREA RES INST CHEMICAL TECH

  公开号：WO2020036386A1

  公开（公告）日：2020-02-20

  이소인돌린-1온 유도체, 이의 제조방법 및 이를 유효성분으로 포함하는 암의 예방 또는 치료용 약학적 조성물에 관한 것으로, 상기 이소인돌린-1온 유도체는 EGFR 돌연변이에 대하여 높은 억제능을 나타내므로, EGFR 돌연변이가 발생된 암의 치료에 유용하게 사용될 수 있고, 병용투여시에 현저한 시너지 효과를 나타내므로, 병용투여 치료에도 유용하게 사용될 수 있다.