bis(pentafluorophenyl)-1,10-phenanthroline-2,9-dicarboxylate | 516462-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: bis(pentafluorophenyl)-1,10-phenanthroline-2,9-dicarboxylate
• 英文别名: Bis(2,3,4,5,6-pentafluorophenyl) 1,10-phenanthroline-2,9-dicarboxylate
• CAS: 516462-64-9
• 化学式: C₂₆H₆F₁₀N₂O₄
• 分子量: 600.329
• InChiKey: NUQOWKBMIMHSPS-UHFFFAOYSA-N

物化性质

• 沸点：
  711.6±60.0 °C(predicted)
• 密度：
  1.700±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.4
• 氢给体数：
  0
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  bis(pentafluorophenyl)-1,10-phenanthroline-2,9-dicarboxylate 在 sodium tetrahydroborate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 8.0h， 生成 2,9-二羟甲基-1,10-菲啰啉
  参考文献：
  名称：

  Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity

  摘要：

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

  DOI：

  10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n
• 作为产物：
  描述：

  三氟乙酸五氟苯酯 、 1,10-邻二氮杂菲-2,9-二甲酸 以 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以98%的产率得到bis(pentafluorophenyl)-1,10-phenanthroline-2,9-dicarboxylate
  参考文献：
  名称：

  Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity

  摘要：

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).

  DOI：

  10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n

文献信息

• Synthesis of Triple Helix Forming Oligonucleotides with a Phenanthroline Moiety into the 3′-3′ Inversion Site of Polarity
  作者：Veronica Esposito、Aldo Galeone、Luciano Mayol、Giorgia Oliviero、Antonio Randazzo、Michela Varra

  DOI：10.1002/1099-0690(200212)2002:24<4228::aid-ejoc4228>3.0.co;2-n

  日期：2002.12

  A protocol for the synthesis of triplex forming oligonucleotides containing a chelating molecule in the 3'-3' inversion site of polarity is reported. A number of 16-mers have been synthesized and UV spectroscopy employed to evaluate the stability of their triple helix complexes with the pertinent double-strand oligonucleotide targets. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).