3,5-bis((bis(pyridin-2-ylmethyl)amino)methyl)-4-hydroxybenzoic acid | 1166841-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-bis((bis(pyridin-2-ylmethyl)amino)methyl)-4-hydroxybenzoic acid
• 英文别名: 3,5-bis[(bis(2-pyridylmethyl)amino)methyl]-4-hydroxy-benzoic acid；3,5-Bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-hydroxybenzoic acid；3,5-bis[[bis(pyridin-2-ylmethyl)amino]methyl]-4-hydroxybenzoic acid
• CAS: 1166841-61-7
• 化学式: C₃₃H₃₂N₆O₃
• 分子量: 560.655
• InChiKey: TWGXAWMMUCWXDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  methyl 3,5-bis[bis(pyridin-2-ylmethyl)aminomethyl]-4-hydroxybenzoate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 以26.3%的产率得到3,5-bis((bis(pyridin-2-ylmethyl)amino)methyl)-4-hydroxybenzoic acid
  参考文献：
  名称：

  Polyglycerol-bound phosphotriesterase enzyme model complexes for detection and hydrolysis of phosphorus species in aqueous solution

  摘要：

  Phosphotriesterase models incorporating di(2-picolyl)amino ligands supported by m-xylylene or 2-hydroxy-m-xylylene scaffolds have been tethered to the periphery of a water-soluble hyperbranched polyglycerol (PG). In aqueous solution buffered at pH 7.4, the polymeric complexes of Zn2+ are useful receptors for polymeric indicator displacement assays for phosphate and pyrophosphate employing commercial complexometric indicators. Under the same conditions, the Co3+ effectively hydrolyze p-nitrophenylphosphate with approximately five orders of magnitude rate enhancement versus uncatalyzed hydrolysis. These systems offer promising results as mixed-metal dual detect-decontaminate materials for organophosphorus toxins under mild, neutral aqueous conditions. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.051

文献信息

• Akt-specific capture agents, compositions, and methods of using and making
  申请人：Heath James R.

  公开号：US09239332B2

  公开（公告）日：2016-01-19

  The present application provides stable peptide-based Akt capture agents and the use thereof as detection, diagnosis, and treatment agents. The application further provides novel methods of developing stable peptide-based capture agents, including Akt capture agents, using iterative on-bead in situ click chemistry.

  本申请提供了稳定的基于肽的Akt捕获剂及其作为检测、诊断和治疗剂的用途。申请还提供了使用迭代的现场点击化学在珠上制备稳定的基于肽的捕获剂的新方法，包括Akt捕获剂。
• PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
  申请人：California Institute of Technology

  公开号：US20150219657A1

  公开（公告）日：2015-08-06

  The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

  本申请提供了稳定的基于肽的Akt捕获剂及其用作检测和诊断剂以及治疗疾病和障碍的方法。该申请进一步提供了使用迭代在珠上原位点击化学制造Akt捕获剂的方法。
• Phosphorylated Akt-specific capture agents, compositions, and methods of using and making
  申请人：California Institute of Technology

  公开号：US11371994B2

  公开（公告）日：2022-06-28

  The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

  本申请提供了基于稳定多肽的 Akt 捕获剂，以及用作检测和诊断剂以及治疗疾病和失调的方法。本申请还提供了利用迭代珠上原位点击化学制造 Akt 捕获剂的方法。
• AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
  申请人：Indi Molecular, Inc.

  公开号：EP2732291B1

  公开（公告）日：2017-11-29
• US9239332B2
  申请人：——

  公开号：US9239332B2

  公开（公告）日：2016-01-19