2-hydroxy-N-methyl-3-[4-(4-phenylphenoxy)butoxy]propanamide | 436151-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-N-methyl-3-[4-(4-phenylphenoxy)butoxy]propanamide
• CAS: 436151-78-9
• 化学式: C₂₀H₂₅NO₄
• 分子量: 343.423
• InChiKey: BEZUNSRBRGGNFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N-methyl-3-[4-(4-phenylphenoxy)butoxy]propanamide 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 生成 N-methyl-2-oxo-3-[4-(4-phenylphenoxy)butoxy]propanamide
  参考文献：
  名称：

  α-Keto amides as inhibitors of histone deacetylase

  摘要：

  alpha-Keto ester and amides were found to be potent inhibitors of historic deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The alpha-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00685-1
• 作为产物：
  描述：

  2-Hydroxy-3-[4-(4-phenylphenoxy)butoxy]propanenitrile 在 氢溴酸 作用下， 以 甲醇 为溶剂， 生成 2-hydroxy-N-methyl-3-[4-(4-phenylphenoxy)butoxy]propanamide
  参考文献：
  名称：

  α-Keto amides as inhibitors of histone deacetylase

  摘要：

  alpha-Keto ester and amides were found to be potent inhibitors of historic deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The alpha-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00685-1

文献信息

• Inhibitors of histone deacetylase
  申请人：——

  公开号：US20020177594A1

  公开（公告）日：2002-11-28

  Compounds having the formula 1 or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.

  具有以下化学式的化合物或其治疗上可接受的盐是组蛋白去乙酰化酶（HDAC）抑制剂。本文揭示了该化合物的制备、含有该化合物的组合物以及使用该化合物治疗疾病的方法。
• [EN] INHIBITORS OF HISTONE DEACETYLASE<br/>[FR] INHIBITEURS DE L'HISTONE DEACETYLASE
  申请人：ABBOTT LAB

  公开号：WO2002046129A2

  公开（公告）日：2002-06-13

  Compounds having the formula or therapeutically acceptable salts thereof, are histone deacetylase (HDAC) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of diseases using the compounds are disclosed.
• α-Keto amides as inhibitors of histone deacetylase
  作者：Carol K. Wada、Robin R. Frey、Zhiqin Ji、Michael L. Curtin、Robert B. Garland、James H. Holms、Junling Li、Lori J. Pease、Jun Guo、Keith B. Glaser、Patrick A. Marcotte、Paul L. Richardson、Shannon S. Murphy、Jennifer J. Bouska、Paul Tapang、Terrance J. Magoc、Daniel H. Albert、Steven K. Davidsen、Michael R. Michaelides

  DOI：10.1016/s0960-894x(03)00685-1

  日期：2003.10

  alpha-Keto ester and amides were found to be potent inhibitors of historic deacetylase. Nanomolar inhibitors against the isolated enzyme and sub-micromolar inhibitors of cellular proliferation were obtained. The alpha-keto amide 30 also exhibited significant anti-tumor effects in an in vivo tumor model. (C) 2003 Elsevier Ltd. All rights reserved.