3-amino-6-(4-oxo-piperidin-1-yl)-4-propyl-thieno[2,3-b]pyridine-2-carboxylic acid amide | 635728-60-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩并吡啶类
• 英文名称: 3-amino-6-(4-oxo-piperidin-1-yl)-4-propyl-thieno[2,3-b]pyridine-2-carboxylic acid amide
• 英文别名: 3-amino-6-(4-oxopiperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxylic acid amide；3-Amino-6-(4-oxo-piperidin-1-yl)4-propyl-thieno[2,3-b]pyridine-2-carboxylic acid amide；3-amino-6-(4-oxopiperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxamide
• CAS: 635728-60-8
• 化学式: C₁₆H₂₀N₄O₂S
• 分子量: 332.426
• InChiKey: OYWOGJOEDCLNEU-UHFFFAOYSA-N

物化性质

• 沸点：
  617.0±55.0 °C(Predicted)
• 密度：
  1.355±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-amino-6-(4-oxo-piperidin-1-yl)-4-propyl-thieno[2,3-b]pyridine-2-carboxylic acid amide 、 3-氨基-1,2-丙二醇 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 72.0h， 以45%的产率得到3-amino-6-(4-(2,3-dihydroxypropylamino)piperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxylic acid amide
  参考文献：
  名称：

  [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
  [FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIQUE SUBSTITUES ET PROCESSUS DE PREPARATION ET D'UTILISATION DE CES COMPOSES

  摘要：

  公开的是式(I)的化合物，其中R1和R2如本文所定义，这些化合物可用作IκB激酶（IKK）复合物激酶活性的抑制剂。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫疾病、炎症性疾病和癌症方面是有用的。还公开了包含这些化合物的药物组合物以及制备这些化合物的方法。

  公开号：

  WO2003103661A1

文献信息

• [EN] SUBSTITUTED 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AS IKK INHIBITORS<br/>[FR] COMPOSES AMIDE D'ACIDE 3-AMINO-THIENO[2,3-B] PYRIDINE-2-CARBOXYLIQUE SUBSTITUE SERVANT D'INHIBITEURS D'IKK
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2005056562A1

  公开（公告）日：2005-06-23

  Disclosed are compounds of formula (I): wherein the variables R1, R2, R3 and Z are described herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  披露了公式(I)的化合物：其中变量R1、R2、R3和Z如本文所述，它们作为IκB激酶(IKK)复合物的激酶活性的抑制剂是有用的。因此，这些化合物在治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症方面是有用的。还披露了包含这些化合物的药物组合物以及制备这些化合物的方法。
• Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Cywin L. Charles

  公开号：US20050288285A1

  公开（公告）日：2005-12-29

  Disclosed are compounds of formula (I): wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明涉及化合物(I)的公开，其中R1和R2在此定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物可用于治疗由IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。还公开了包含这些化合物的药物组合物和制备这些化合物的过程。
• Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Boehringer Ingelheim Pharmaceuticals, Inc.

  公开号：US20040053957A1

  公开（公告）日：2004-03-18

  Disclosed are compounds of formula (I): 1 wherein R 1 and R 2 are defined herein, which are useful as inhibitors of the kinase activity of the I&kgr;B kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

  本发明公开了式(I)的化合物：其中R1和R2在此定义，这些化合物可用作IκB激酶（IKK）复合物的激酶活性抑制剂。因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫性疾病、炎症性疾病和癌症。本发明还公开了包含这些化合物的制药组合物和制备这些化合物的过程。
• Substituted 3-amino-thieno[2,3-b] pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses
  申请人：Chen Zhidong

  公开号：US20060270671A1

  公开（公告）日：2006-11-30

  Disclosed are methods of treating cancer by administration of compounds according to formula (I): wherein the variables R 1 , R 2 , R 3 and Z are described herein.

  本发明涉及通过给予式(I)所述化合物治疗癌症的方法：其中变量R1、R2、R3和Z的描述如下。
• SUBSTITUTED 3-AMINO-THIENO[2,3-b]PYRIDINE-2-CARBOXYLIC ACID AMIDE COMPOUNDS AND PROCESSES FOR PREPARING AND THEIR USES
  申请人：Chen Zhidong

  公开号：US20080312185A1

  公开（公告）日：2008-12-18

  Disclosed are methods of treating cancer by administration of compounds according to formula (I): wherein the variables R 1 , R 2 , R 3 and Z are described herein.

  公开了一种使用公式(I)的化合物治疗癌症的方法，其中变量R1、R2、R3和Z的描述如下。