3,3',4,4'-tetraaminodiphenyl sulfide | 13107-57-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3,3',4,4'-tetraaminodiphenyl sulfide
• 英文别名: 4-(3,4-Diaminophenyl)sulfanylbenzene-1,2-diamine
• CAS: 13107-57-8
• 化学式: C₁₂H₁₄N₄S
• 分子量: 246.336
• InChiKey: URMNVIKGFSSFRC-UHFFFAOYSA-N

物化性质

• 沸点：
  590.8±50.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,3-二羧甲基-2-甲基-2-硫代异脲 、 3,3',4,4'-tetraaminodiphenyl sulfide 以 乙醇 为溶剂， 反应 12.0h， 以64%的产率得到2,2'-dicarbomethoxyamino-5,5'-dibenzimidazolyl sulfide
  参考文献：
  名称：

  Abuzar; Sharma; Visen, Arzneimittel-Forschung/Drug Research, 1986, vol. 36, # 3, p. 416 - 419

  摘要：

  DOI：
• 作为产物：
  描述：

  Bis(4-amino-3-nitrophenyl) sulfide 在 镍 氢气 作用下， 以 甲醇 为溶剂， 生成 3,3',4,4'-tetraaminodiphenyl sulfide
  参考文献：
  名称：

  Viswanathan, N.; Joshi, B. S.; Gawad, D. H., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 730 - 732

  摘要：

  DOI：

文献信息

• NOVEL 6-TRIAZOLOPYRIDAZINESULFANYL BENZOTHIAZOLE AND BENZIMIDAZOLE DERIVATIVES, METHOD FOR PRODUCTION THEREOF AND APPLICATION AS MEDICAMENTS AND PHARMNACEUTICAL COMPOSITIONS AND NOVEL USE AS MET INHIBITORS
  申请人：ALBERT Eva

  公开号：US20100298315A1

  公开（公告）日：2010-11-25

  The disclosure relates to compounds of formula (I): wherein , A, W, X, and Ra are as defined in the disclosure, and salts thereof, and to pharmaceutical compositions comprising said compounds, to processes for preparing them, and to their use as medicaments, in particular as MET inhibitors.

  该公开涉及式(I)的化合物： 其中 ，A、W、X和Ra如公开所定义，并其盐，以及包含所述化合物的药物组合物，用于制备它们的方法，以及它们作为药物的用途，特别是作为MET抑制剂。
• Asymmetric Diamine Compounds Containing Two Functional Groups and Polymers Therefrom
  申请人：KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20150045481A1

  公开（公告）日：2015-02-12

  The present invention relates to a novel diamine compound, wherein two substituents R and R′ are introduced asymmetrically, and a polymer thereof. The polymer may have excellent solubility in the organic solvent and allows for easy processibility after imidization, thus giving proper film maintaining superior properties, such as thermal, mechanical, and optical properties for applications in electrical, electronic, or optical materials.

  本发明涉及一种新型二胺化合物，其中引入了两个不对称的取代基R和R'，以及其聚合物。该聚合物在有机溶剂中具有出色的溶解性，并在酰亚胺化后易于加工，从而形成具有优越热性能、机械性能和光学性能的适用于电气、电子或光学材料的适当薄膜。
• POLYBENZIMIDAZOLES AND METHODS OF MAKING AND USING THEREOF
  申请人：BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

  公开号：US20170081477A1

  公开（公告）日：2017-03-23

  Disclosed are polybenzimidazoles containing sulfonyl groups. The polymers can be synthesized in Eaton's reagent from 3,3′,4,4′-tetraaminodiphenylsulfone, which itself can be synthesized from 4,4′-dichlorodiphenylsulfone. Methods of synthesizing the polymers are disclosed. The disclosed polymers can be used for high temperature H 2 /CO 2 separation membranes and other uses.

  揭示了含有磺酰基团的聚苯并咪唑。这些聚合物可以从3,3′,4,4′-四氨基二苯砜在伊顿试剂中合成，而这种化合物本身可以从4,4′-二氯二苯砜合成。公开了合成这些聚合物的方法。这些聚合物可用于高温H2/CO2分离膜和其他用途。
• DERIVATIVES OF 6-(6-NH-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS
  申请人：Bacque Eric

  公开号：US20120040987A1

  公开（公告）日：2012-02-16

  The invention relates to novel products of the formula (I) where: (II) is a single or double bond; Rb is a hydrogen or fluorine atom; Ra is a NH-Rc radical in which Rc is an optionally substituted heterocycloalkyl, aryl, heteroaryl or -alkylcycloalkyl radical; X is S, SO, or SO2; A is NH or S; W is H, alkyl, or COR with R being cycloalkyl; alkyl; alkoxy; O-phenyl; —O— (CH2)n-phenyl with n=1 to 4; or NR1R2 with R1 being H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle together with N optionally containing O, S, N and/or NH; all of said radicals being optionally substituted; wherein said products can be in any isomer or salt form, and can be used as drugs, in particular as MET inhibitors.

  本发明涉及式(I)的新型产物，其中：(II)是单键或双键；Rb是氢或氟原子；Ra是NH-Rc基团，其中Rc是可选取代的杂环烷基、芳基、杂芳基或-烷基环烷基基团；X是S、SO或SO2；A是NH或S；W是H、烷基或COR，其中R是环烷基、烷基、烷氧基、O-苯基、-O-(CH2)n-苯基，其中n为1至4，或NR1R2，其中R1为H或烷基，R2为H、环烷基或烷基；或R1、R2与N一起形成含有O、S、N和/或NH的环；所述基团均可选取代；其中所述产物可以是任何异构体或盐形式，并可用作药物，特别是作为MET抑制剂。
• NOVEL 6-TRIAZOLOPYRIDAZINE SULFANYL BENZOTHIAZOLE DERIVATIVES AS MET INHIBITORS
  申请人：Albert Eva

  公开号：US20140005189A1

  公开（公告）日：2014-01-02

  The disclosure relates to compounds of formula (I): wherein , A, W, X, and Ra are as defined in the disclosure, and salts thereof, and to pharmaceutical compositions comprising said compounds, to processes for preparing them, and to their use as medicaments, in particular as MET inhibitors.

  本公开涉及式(I)的化合物：其中，A、W、X和Ra如本公开所定义的那样，以及其盐，以及包含所述化合物的制药组合物，制备它们的过程，以及它们作为药物的用途，特别是作为MET抑制剂的用途。