2-氯-4-碘吡啶-3-胺 | 153034-93-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氯-4-碘吡啶-3-胺
• 英文名称: 3-Amino-2-chloro-4-iodopyridine
• 英文别名: 2-chloro-4-iodo-3-pyridylamine；2-chloro-4-iodo-pyridin-3-amine；2-Chloro-4-iodopyridin-3-amine
• CAS: 153034-93-6
• 化学式: C₅H₄ClIN₂
• 分子量: 254.458
• InChiKey: OMOGWKQVHILZND-UHFFFAOYSA-N

物化性质

• 沸点：
  333.4±42.0 °C(Predicted)
• 密度：
  2.139±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氯-4-碘吡啶-3-胺 在 四(三苯基膦)钯 potassium carbonate 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 31.5h， 生成 lactam of o-(3-aminopyridyl-4)benzoic acid
  参考文献：
  名称：

  First metalation of aryl iodides: directed ortho-lithiation of iodopyridines, halogen-dance, and application to synthesis

  摘要：

  Metalation of iodopyridines was successfully achieved by LDA at low temperature. In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines. This procedure was applied to 2-fluoro-and 2-chloro-3-iodopyridines, 3-fluoro-4-iodopyridine, and 2-chloro-3-fluoro-4-iodopyridine. The resulting lithio intermediates were obtained in high yields before being reacted with electrophiles leading to various polysubstituted pyridines. Some of these iodopyridines were used as key molecules for the synthesis of fused polyaromatic alkaloids. Thus, perlolidine, delta-carbolines, and 2,10-diazaphenanthrenes were readily prepared in few steps taking advantage of the iodo reactivity for heteroring cross-coupling.

  DOI：

  10.1021/jo00079a031
• 作为产物：
  描述：

  3-叠氮基-2-氯-4-碘吡啶 在 哌啶 、 硫化氢 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以57%的产率得到2-氯-4-碘吡啶-3-胺
  参考文献：
  名称：

  First metalation of aryl iodides: directed ortho-lithiation of iodopyridines, halogen-dance, and application to synthesis

  摘要：

  Metalation of iodopyridines was successfully achieved by LDA at low temperature. In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines. This procedure was applied to 2-fluoro-and 2-chloro-3-iodopyridines, 3-fluoro-4-iodopyridine, and 2-chloro-3-fluoro-4-iodopyridine. The resulting lithio intermediates were obtained in high yields before being reacted with electrophiles leading to various polysubstituted pyridines. Some of these iodopyridines were used as key molecules for the synthesis of fused polyaromatic alkaloids. Thus, perlolidine, delta-carbolines, and 2,10-diazaphenanthrenes were readily prepared in few steps taking advantage of the iodo reactivity for heteroring cross-coupling.

  DOI：

  10.1021/jo00079a031

文献信息

• 过渡金属配合物、聚合物、混合物、组合物及有机电子器件
  申请人：广州华睿光电材料有限公司

  公开号：CN110981895B

  公开（公告）日：2023-08-25

  本发明公开了一种过渡金属配合物、聚合物、混合物、组合物及有机电子器件。该过渡金属配合物，具有如化学式(1)所示的结构通式，其合成简单、结构新颖，同时具有较好的稳定性、寿命长，发光性能好，化学式(1)便于实现高效、高亮度、高稳定的OLED器件，对全彩显示和照明应用提供了较好的材料选项。。
• BICYCLIC HETEROAROMATIC COMPOUNDS
  申请人：Heinrich Timo

  公开号：US20150218155A1

  公开（公告）日：2015-08-06

  Compounds of the formula I, in which X1, X2, X3, X4, X5, R1, R2, R3, R4, R5 and R6 have the meanings indicated in Claim 1 , are kinase inhibitors and can be employed, inter alia, for the treatment of tumours.

  公式I中的化合物，其中X1、X2、X3、X4、X5、R1、R2、R3、R4、R5和R6的含义如权利要求书中所示，是激酶抑制剂，可用于治疗肿瘤等疾病。
• AZAINDOLE INHIBITORS OF IAP
  申请人：Bergeron Philippe

  公开号：US20110218211A1

  公开（公告）日：2011-09-08

  The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: I wherein X 1 , X 2 , Y, Z 1 , Z 2 , Z 3 , Z 4 , R 1 , R 2 , R 3 , R 3 ′, R 4 , R 4 ′, R 5 , R 6 , R 6 ′ and R 9 are as described herein.
• US9249140B2
  申请人：——

  公开号：US9249140B2

  公开（公告）日：2016-02-02
• [EN] NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT COMPRISING SAME<br/>[FR] NOUVEAU COMPOSÉ ET ÉLÉMENT ÉLECTROLUMINESCENT ORGANIQUE LE COMPRENANT<br/>[KO] 신규한 화합물 및 이를 이용한 유기 발광 소자
  申请人：LG CHEMICAL LTD

  公开号：WO2021210911A1

  公开（公告）日：2021-10-21

  본 발명은 신규한 화합물 및 이를 이용한 유기발광 소자를 제공한다.