4-[2-(Oxolan-2-yloxy)ethyl]phenol | 1258157-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-[2-(Oxolan-2-yloxy)ethyl]phenol
• CAS: 1258157-35-5
• 化学式: C₁₂H₁₆O₃
• 分子量: 208.257
• InChiKey: HTJVNORIIVZKLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  四氢呋喃 、 对羟基苯乙醇 在 3-氯丙烯 作用下， 反应 15.0h， 以45%的产率得到4-[2-(Oxolan-2-yloxy)ethyl]phenol
  参考文献：
  名称：

  An economic and efficient tetrahydrofuranylation of alcohols, imines and alkynes

  摘要：

  The tetrahydrofuranyl radical, generated by heating tetrahydrofuran in the presence of air and allyl or benzyl chloride, becomes a useful tool in order to transform the hydroxyl functions into ethers, or the C=N double bond into amine, or the C-C triple bond into vinyl derivatives. A radical mechanism is proposed followed by a nucleophilic substitution for the alcohol substrate and a radical addition for the iminic and the acetylenic reactants. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.014

文献信息

• An economic and efficient tetrahydrofuranylation of alcohols, imines and alkynes
  作者：Luigino Troisi、Catia Granito、Ludovico Ronzini、Francesca Rosato、Valeria Videtta

  DOI：10.1016/j.tetlet.2010.09.014

  日期：2010.11

  The tetrahydrofuranyl radical, generated by heating tetrahydrofuran in the presence of air and allyl or benzyl chloride, becomes a useful tool in order to transform the hydroxyl functions into ethers, or the C=N double bond into amine, or the C-C triple bond into vinyl derivatives. A radical mechanism is proposed followed by a nucleophilic substitution for the alcohol substrate and a radical addition for the iminic and the acetylenic reactants. (C) 2010 Elsevier Ltd. All rights reserved.