3,4,5-trihydroxyphenethyl alcohol methylether | 1375102-42-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3,4,5-trihydroxyphenethyl alcohol methylether
• 英文别名: 3,4,5-Trihydroxyphenethyl methyl ether；5-(2-methoxyethyl)benzene-1,2,3-triol
• CAS: 1375102-42-3
• 化学式: C₉H₁₂O₄
• 分子量: 184.192
• InChiKey: HLFKICCDIMPQOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对羟基苯乙醇 在 potassium peroxymonosulfate 、 三溴化硼 、 碳酸二甲酯 、 sodium bromide 、 copper(I) bromide 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 39.0h， 生成 3,4,5-trihydroxyphenethyl alcohol methylether
  参考文献：
  名称：

  Synthesis and biological evaluation of gallic acid analogs

  摘要：

  A novel and efficient synthesis of pyrogallol moiety through a copper(I)-mediated C-O bond forming reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative are reported. Particular attention to dimethyl carbonate as an eco-friendly solvent/reactant has been paid, in order to improve the eco-compatibility of the whole synthetic pathway. Furthermore, the genotoxicity, cytotoxicity and the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative have been investigated.

  DOI：

  10.1007/s00044-012-0052-8

文献信息

• Synthesis and biological evaluation of gallic acid analogs
  作者：Maurizio Barontini、Ilaria Proietti Silvestri、Valentina Nardi、Fernanda Crisante、Gaetano Pepe、Luigi Pari、Francesco Gallucci、Paolo Bovicelli、Giuliana Righi

  DOI：10.1007/s00044-012-0052-8

  日期：2013.2

  A novel and efficient synthesis of pyrogallol moiety through a copper(I)-mediated C-O bond forming reaction is described. In particular, syntheses of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative are reported. Particular attention to dimethyl carbonate as an eco-friendly solvent/reactant has been paid, in order to improve the eco-compatibility of the whole synthetic pathway. Furthermore, the genotoxicity, cytotoxicity and the antioxidant activity of 3,4,5-trihydroxyphenethyl alcohol and its methyl derivative have been investigated.