triphenyl-[[(1R,8R)-3,4,5,6-tetrafluoro-11-(triphenylsilyloxymethyl)-9-tricyclo[6.2.2.02,7]dodeca-2(7),3,5,9,11-pentaenyl]methoxy]silane | 1067879-53-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: triphenyl-[[(1R,8R)-3,4,5,6-tetrafluoro-11-(triphenylsilyloxymethyl)-9-tricyclo[6.2.2.02,7]dodeca-2(7),3,5,9,11-pentaenyl]methoxy]silane
• CAS: 1067879-53-1
• 化学式: C₅₀H₃₈F₄O₂Si₂
• 分子量: 803.015
• InChiKey: LXSCDKVITBRSNX-NDOUMJCMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.66
• 重原子数：
  58
• 可旋转键数：
  12
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  三苯基氯硅烷 、 [(1R,8R)-3,4,5,6-tetrafluoro-11-(hydroxymethyl)-9-tricyclo[6.2.2.02,7]dodeca-2(7),3,5,9,11-pentaenyl]methanol 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以86%的产率得到triphenyl-[[(1R,8R)-3,4,5,6-tetrafluoro-11-(triphenylsilyloxymethyl)-9-tricyclo[6.2.2.02,7]dodeca-2(7),3,5,9,11-pentaenyl]methoxy]silane
  参考文献：
  名称：

  C2-Symmetric tetrafluorobenzobarrelenes as highly efficient ligands for the iridium-catalyzed asymmetric annulation of 1,3-dienes with 2-formylphenylboron reagents

  摘要：

  New C-2-symmetric chiral diene ligands bearing a tetraflurobenzobarrelene framework were prepared via a [4+2] cycloaddition of 1,4-bis((methoxymethoxy)methyl)benzene with tetrafluorobenzyne. The diene ligands realized the iridium-catalyzed enantioselective [3+2] annulation of 1,3-dienes with 2-formylphenylboron reagents giving 1-indanol derivatives in high yields and with high enantioselectivities. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.07.014

文献信息

• C2-Symmetric tetrafluorobenzobarrelenes as highly efficient ligands for the iridium-catalyzed asymmetric annulation of 1,3-dienes with 2-formylphenylboron reagents
  作者：Takahiro Nishimura、Yuichi Yasuhara、Makoto Nagaosa、Tamio Hayashi

  DOI：10.1016/j.tetasy.2008.07.014

  日期：2008.8

  New C-2-symmetric chiral diene ligands bearing a tetraflurobenzobarrelene framework were prepared via a [4+2] cycloaddition of 1,4-bis((methoxymethoxy)methyl)benzene with tetrafluorobenzyne. The diene ligands realized the iridium-catalyzed enantioselective [3+2] annulation of 1,3-dienes with 2-formylphenylboron reagents giving 1-indanol derivatives in high yields and with high enantioselectivities. (C) 2008 Elsevier Ltd. All rights reserved.