2-氯-6-(二氯甲基)吡啶 | 78152-53-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-氯-6-(二氯甲基)吡啶
• 英文名称: 2-Chloro-6-(dichloromethyl)-pyridine
• 英文别名: 2-(dichloromethyl)-6-chloropyridine；2-Chloro-6-(dichloromethyl)pyridine
• CAS: 78152-53-1
• 化学式: C₆H₄Cl₃N
• 分子量: 196.463
• InChiKey: OBMOIJAXNPCIDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  2-氯-6-(二氯甲基)吡啶 生成 2-[Bis(4-chlorophenoxy)methyl]-6-chloropyridine
  参考文献：
  名称：

  MALHOTRA, S. K.

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氯-6-三氯甲基吡啶 在 sodium hydroxide 氯仿 作用下， 以88%的产率得到2-氯-6-(二氯甲基)吡啶
  参考文献：
  名称：

  An equilibrium halogen transfer reaction with evidence for SRN1-like behavior

  摘要：

  The ''reduction'' of 2-chloro-6-(trichloromethyl)pyridine to the dichloromethyl derivative by chloroform under basic conditions yields carbon tetrachloride as a companion product. The reaction is demonstrated to be reversible and to have preparative value. Strong inhibition by electron capture agents and also strong acceleration by electron-donating agents. is observed. The mechanistic interpretation is electron-transfer initiation followed by reversible radical chains to establish the equilibrium.

  DOI：

  10.1021/jo00080a005

文献信息

• 6-(Substituted phenoxy)-2-di-(substituted phenoxy)methyl pyridines
  申请人：The Dow Chemical Company

  公开号：US04324896A1

  公开（公告）日：1982-04-13

  Compounds are prepared corresponding to the formula ##STR1## wherein Y represents chloro or R'; R represents ##STR2## wherein X independently represents alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, alkyl sulfonyl of 1 to 4 carbon atoms, trifluoromethyl, chloro, fluoro or bromo; n represents an integer of 0 to 2 or X.sub.n represents 3,4-methylenedioxy and R' represents R with the proviso that R and R' can be the same or different. The compounds are useful as intermediates for the preparation of insecticidal substituted pyridine methyl esters of cyclopropane carboxylic acids.

  根据以下公式制备相应的化合物##STR1##其中Y代表氯或R'; R代表##STR2##其中X独立表示1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷基硫基，1至4个碳原子的烷基磺酰基，三氟甲基，氯，氟或溴; n表示0至2的整数或X.sub.n表示3,4-亚甲二氧基，R'表示R，但R和R'可以相同也可以不同。这些化合物可用作制备杀虫剂取代吡啶甲酯环丙烷羧酸的中间体。
• Method for preparing 2-chloro-6-trichloromethylpyridine through liquid phase photochlorination of 2-methylpyridine
  申请人：Zhejiang Avilive Chemical Co., Ltd.

  公开号：US10577326B1

  公开（公告）日：2020-03-03

  The present invention relates to a method for preparing 2-chloro-6-trichloromethylpyridine with product purity greater than or equal to 99.0% by using trifluoromethyl chlorobenzene as a solvent for reaction between 2-methylpyridine with chlorine gas, in which 2-methylpyridine and chlorine gas are used as starting materials, trifluoromethyl chlorobenzene is used as a solvent, 2-methylpyridine is prepared into a liquid raw material by using the solvent trifluoromethyl chlorobenzene, and the liquid raw material is continuously fed to perform liquid phase photochlorination reaction at temperature of 160-240° C. under irradiation of ultraviolet light to obtain 2-chloro-6-trichloromethylpyridine solution. Advantages: the selectivity of reaction for the production of 2-chloro-6-trichloromethylpyridine is improved, the content of components such as isomers and pentachloromethylpyridine in the crude product is decreased significantly, the crude product is easy to be purified to obtain the 2-chloro-6-trichloromethylpyridine product with purity greater than or equal to 99.0%, and the industrial production is facilitated; and secondly, not only can the reuse of the separated solvent in the preparation process of the 2,6-dichloropyridine product with purity greater than or equal to 99.0% be realized, but also the purposes of low pollution, low energy consumption and low cost in the preparation process are realized.

  本发明涉及一种制备纯度大于或等于99.0％的2-氯-6-三氯甲基吡啶的方法，其利用三氟甲基氯苯作为反应溶剂，在2-甲基吡啶与氯气之间的反应中，使用2-甲基吡啶和氯气作为起始原料，三氟甲基氯苯作为溶剂，通过使用三氟甲基氯苯溶剂将2-甲基吡啶制备成液体原料，并连续供给液体原料，在160-240°C的温度下，在紫外光照射下进行液相光氯化反应，以获得2-氯-6-三氯甲基吡啶溶液。优点：提高了生产2-氯-6-三氯甲基吡啶的反应选择性，明显降低了原料中异构体和五氯甲基吡啶等组分的含量，易于纯化原料以获得纯度大于或等于99.0％的2-氯-6-三氯甲基吡啶产品，并便于工业生产；其次，在制备纯度大于或等于99.0％的2,6-二氯吡啶产品的制备过程中，不仅可以实现分离溶剂的再利用，还实现了低污染、低能耗和低成本的目的。
• COMPOUND CONTAINING PYRIDINE RING AND METHOD FOR PRODUCING HALOGENATED PICOLINE DERIVATIVE AND TETRAZOLYLOXIME DERIVATIVE
  申请人：Miyazaki Hidekazu

  公开号：US20130012713A1

  公开（公告）日：2013-01-10

  Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein R 0 represents a C 1-6 alkoxy group, C 1-6 alkoxy-C 1-6 alkoxy group or the like, R 1 represents a C 1-2 alkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.

  本发明公开了一种含有吡啶环的化合物，可以以工业上有利的方式合成，并且可用作生产具有杀真菌活性的四唑氧肟衍生物的中间体（其中R0代表C1-6烷氧基基团，C1-6烷氧基-C1-6烷氧基基团或类似物，R1代表C1-2烷氧羰基基团，乙酰基基团或类似物，Z代表卤素原子，氰基团或类似物，X代表卤素原子，n代表0至3的整数），以及用于生产2-取代氨基-6-卤甲基吡啶衍生物和四唑氧肟衍生物的工业上有利的生产方法。
• Reduction of trichloromethylpyridines to dichloromethylpyridines
  申请人：The Dow Chemical Company

  公开号：US04499277A1

  公开（公告）日：1985-02-12

  2(6)-(Trichloromethyl)pyridines are reduced to the corresponding 2(6)-(dichloromethyl)pyridines by treatment with a strong base and an anionic reductant derived from a reductant source material selected from the group consisting of dialkylphosphite and trialkylphosphite said treatment taking place in the presence of a polar, non-hydroxylic solvent and/or a phase transfer catalyst.

  2(6)-(三氯甲基)吡啶通过使用强碱和源自于二烷基膦酸酯和三烷基膦酸酯还原剂的阴离子还原剂处理，在极性、非羟基溶剂和/或相转移催化剂存在下，被还原为相应的2(6)-(二氯甲基)吡啶。
• Preparation of (dichloromethyl) pyridines by reductive dechlorination
  申请人：The Dow Chemical Company

  公开号：US04260766A1

  公开（公告）日：1981-04-07

  (Dichloromethyl) substituted pyridines are prepared from (trichloromethyl) substituted pyridines by the reaction thereof under reductive dechlorination conditions with metallic iron or a ferrous iron compound and an acid.

  (二氯甲基)取代的吡啶可以通过在金属铁或亚铁化合物和酸的还原脱氯条件下与(三氯甲基)取代的吡啶反应而制备。