Methyl-(1-methyl-5-phenyl-1,4,5,6-tetrahydro-pyrimidin-2-yl)-amine | 95724-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Methyl-(1-methyl-5-phenyl-1,4,5,6-tetrahydro-pyrimidin-2-yl)-amine
• 英文别名: N,1-dimethyl-5-phenyl-1,3-diazinan-2-imine
• CAS: 95724-97-3
• 化学式: C₁₂H₁₇N₃
• 分子量: 203.287
• InChiKey: QCESLFTUJXAQLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  27.6
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-<(methoxycarbonyl)amino>-5-phenyl-1,4,5,6-tetrahydropyrimidine 、 碘甲烷 、 sodium 以12%的产率得到
  参考文献：
  名称：

  WEINHARDT, K.;WALLACH, M. B.;MARX, M., J. MED. CHEM., 1985, 28, N 6, 694-698

  摘要：

  DOI：

文献信息

• Synthesis and antidepressant profiles of phenyl-substituted 2-amino- and 2-[(alkoxycarbonyl)amino]-1,4,5,6-tetrahydropyrimidines
  作者：Klaus Weinhardt、Marshall B. Wallach、Michael Marx

  DOI：10.1021/jm00383a002

  日期：1985.6

  A series of 4(6)- and 5-phenyl-substituted 2-amino- and 2-[(alkoxycarbonyl)amino]-1,4,5,6-tetrahydropyrimidines were prepared and evaluated for central nervous system (CNS) effects in animal models. Several 5-phenyl-substituted compounds possessed potent antidepressant activity and all compounds in this series were devoid of significant activity in any of the other CNS (anticonvulsant, muscle relaxant, and depressant) assays. The most active compound in the in vivo screen for antidepressant activity (reversal of reserpine-induced hypothermia), 2-[(methoxycarbonyl)amino]-5-phenyl-1,4,5,6-tetrahydropyrimidine was considerably more potent than tricyclic antidepressant (TCA) standards. The 2-amino parent compound on the other hand was greater than 100-fold as effective as TCA's in in vitro inhibition of norepinephrine and dopamine uptake.
• WEINHARDT, K.;WALLACH, M. B.;MARX, M., J. MED. CHEM., 1985, 28, N 6, 694-698
  作者：WEINHARDT, K.、WALLACH, M. B.、MARX, M.

  DOI：——

  日期：——