N-(tert-butyldimethylsilyloxy)-2-(4-(2-chloro-4-fluoroben-zyloxy)phenylsulfonamido)acetamide | 1430072-53-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(tert-butyldimethylsilyloxy)-2-(4-(2-chloro-4-fluoroben-zyloxy)phenylsulfonamido)acetamide
• 英文别名: N-[tert-butyl(dimethyl)silyl]oxy-2-[[4-[(2-chloro-4-fluorophenyl)methoxy]phenyl]sulfonylamino]acetamide
• CAS: 1430072-53-9
• 化学式: C₂₁H₂₈ClFN₂O₅SSi
• 分子量: 503.067
• InChiKey: VMDHUURBFBZWIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.39
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-(tert-butyldimethylsilyloxy)-2-(4-(2-chloro-4-fluoroben-zyloxy)phenylsulfonamido)acetamide 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以36%的产率得到2-[[4-[(2-chloro-4-fluorophenyl)methoxy]phenyl]sulfonylamino]-N-hydroxyacetamide
  参考文献：
  名称：

  Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation

  摘要：

  Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. We report herein the synthesis and biological evaluation of a series of arylsulfonamido-based hydroxamates as aggrecanase inhibitors. Compound 18 was found to have a nanomolar activity for ADAMTS-5, ADAMTS-4 and MMP-13 and high selectivity over MMP-1 and MMP-14. Furthermore, this compound proved to be effective in blocking ex vivo cartilage degradation without having effect on cell cytotoxicity. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.12.058
• 作为产物：
  描述：

  sodium p-hydroxybenzenesulfonate 在 草酰氯 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 异丙醇 为溶剂， 反应 48.2h， 生成 N-(tert-butyldimethylsilyloxy)-2-(4-(2-chloro-4-fluoroben-zyloxy)phenylsulfonamido)acetamide
  参考文献：
  名称：

  Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: Synthesis and biological evaluation

  摘要：

  Aggrecanases, in particular aggrecanase-2 (ADAMTS-5), are considered the principal proteases responsible for aggrecan degradation in osteoarthritis. For this reason, considerable effort has been put on the discovery and development of aggrecanase inhibitors able to slow down or halt the progression of osteoarthritis. We report herein the synthesis and biological evaluation of a series of arylsulfonamido-based hydroxamates as aggrecanase inhibitors. Compound 18 was found to have a nanomolar activity for ADAMTS-5, ADAMTS-4 and MMP-13 and high selectivity over MMP-1 and MMP-14. Furthermore, this compound proved to be effective in blocking ex vivo cartilage degradation without having effect on cell cytotoxicity. (C) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.12.058