4-(phenothiazin-3-ylideneamino)benzoic acid | 140222-07-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 4-(phenothiazin-3-ylideneamino)benzoic acid
• 英文别名: 3-(4-carboxyphenyl)imino-3H-phenothiazine
• CAS: 140222-07-7
• 化学式: C₁₉H₁₂N₂O₂S
• 分子量: 332.382
• InChiKey: CFIDBRNPCIWYFF-XSFVSMFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.33
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.55
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  吩噻嗪 、 对氨基苯甲酸 在 三氯化铁 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以9.8%的产率得到3-(4-carboxyphenyl)imino-7-(4-carboxyphenyl)amino-3H-phenothiazine
  参考文献：
  名称：

  Baranov, V. N.; Ginzburg, O. F.; Nekhoroshev, A. A., Journal of Organic Chemistry USSR (English Translation), 1991, vol. 27, # 9.2, p. 1778 - 1782

  摘要：

  DOI：

文献信息

• Process of making 3-phenylimino-3h-phenothiazine or 3-phenylimino-3h-phenoxazine mediator
  申请人：Marfurt Karen L.

  公开号：US20090171081A1

  公开（公告）日：2009-07-02

  A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.

  一种制备3-苯基亚胺基-3H-苯并噻嗪或3-苯基亚胺基-3H-苯并噁嗪介质的方法，包括提供含有苯并噻嗪或苯并噁嗪的第一反应物，提供第一溶剂，提供第二反应物和提供第二溶剂。将第一反应物、第一溶剂、第二反应物和第二溶剂混合形成反应物溶液。将过硫酸钠加入反应物溶液中，使第一反应物和第二反应物偶联，从而得到包含3-苯基亚胺基-3H-苯并噻嗪或3-苯基亚胺基-3H-苯并噁嗪介质的反应溶液。
• Reagents and methods for detecting analytes
  申请人：Chu Amy H.

  公开号：US20090145775A1

  公开（公告）日：2009-06-11

  A reagent for detecting an analyte comprises a flavoprotein enzyme, a mediator such as a phenothiazine mediator, at least one surfactant, a polymer and a buffer. The reagent may be used with an electrochemical test sensor that includes a plurality of electrodes.

  用于检测分析物的试剂包括一种黄酮蛋白酶、一种介质，例如苯并噻嗪介质，至少一种表面活性剂、一种聚合物和缓冲剂。该试剂可以与包括多个电极的电化学测试传感器一起使用。
• Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes
  申请人：——

  公开号：US20030094384A1

  公开（公告）日：2003-05-22

  Reagents for detecting an analyte are described. A reagent comprises (a) an enzyme selected from the group consisting of a flavoprotein, a quinoprotein, and a combination thereof; and (b) a mediator selected from the group consisting of a phenothiazine, a phenoxazine, and a combination thereof. In addition, reagents having good stability to radiation sterilization are described. Electrochemical sensors and sampling devices comprising such reagents, methods of producing a sterilized device including such reagents, and methods for detecting an analyte which utilize such reagents are described as well.

  描述了用于检测分析物的试剂。试剂包括：(a) 选自黄蛋白、喹蛋白及其组合的酶；(b) 选自吩噻嗪、吩嗪及其组合的介质。此外，还介绍了对辐射灭菌具有良好稳定性的试剂。此外，还介绍了包括此类试剂的电化学传感器和取样装置、生产包括此类试剂的灭菌装置的方法以及利用此类试剂检测分析物的方法。
• Reagents, methods and devices for detecting analytes
  申请人：BAYER CORPORATION

  公开号：EP1293574B1

  公开（公告）日：2007-11-21
• PROCESS OF MAKING 3-PHENYLIMINO-3H-PHENOTHIAZINE OR 3-PHENYLIMINO-3H-PHENOXAZINE MEDIATOR
  申请人：Bayer HealthCare LLC

  公开号：EP2229590A1

  公开（公告）日：2010-09-22