2-氯-N-(3-甲基苯基)苯甲酰胺 | 2447-92-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯-N-(3-甲基苯基)苯甲酰胺
• 英文名称: 3'-Methyl-2-chlor-benzanilid
• 英文别名: 2-chloro-N-(3-methylphenyl)benzamide
• CAS: 2447-92-9
• 化学式: C₁₄H₁₂ClNO
• mdl: MFCD00087862
• 分子量: 245.708
• InChiKey: QMUDBMHUUBUXHG-UHFFFAOYSA-N

物化性质

• 保留指数：
  2134

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924299090

文献信息

• COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA
  申请人：Fratagene Therapeutics Ltd.

  公开号：US20160083358A1

  公开（公告）日：2016-03-24

  The invention provides compositions and methods useful for the treatment of Friedreich's ataxia. In some embodiments, the invention provides compositions and methods useful for inhibiting the ubiquitination of frataxin.

  这项发明提供了用于治疗弗里德莱希共济失调症的组合物和方法。在某些实施例中，该发明提供了用于抑制frataxin泛素化的组合物和方法。
• Compositions and methods for treating Friedreich's ataxia
  申请人：Fratagene Therapeutics S.R.L.

  公开号：US10442779B2

  公开（公告）日：2019-10-15

  The invention provides compositions and methods useful for the treatment of Friedreich's ataxia. In some embodiments, the invention provides compositions and methods useful for inhibiting the ubiquitination of frataxin.

  本发明提供了用于治疗弗里德里希共济失调的组合物和方法。在某些实施方案中，本发明提供了抑制 frataxin 泛素化的组合物和方法。
• CONDENSED HETEROARYL DERIVATIVES
  申请人：Astellas Pharma Inc.

  公开号：EP1277738B1

  公开（公告）日：2011-03-30
• Fused heteroaryl derivatives
  申请人：Hayakawa Masahiko

  公开号：US20070037805A1

  公开（公告）日：2007-02-15

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
• FUSED HETEROARYL DERIVATIVES
  申请人：HAYAKAWA Masahiko

  公开号：US20100137584A1

  公开（公告）日：2010-06-03

  The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.