N^α-Benzoyllysine | 116783-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N^α-Benzoyllysine
• 英文别名: N-benzoyllysine；N^α-Benzoyl-DL-lysin；α-Benzoyl-lysin；N²-benzoyl-lysine；Inakt. ε-Amino-α-benzamino-n-capronsaeure；N²-benzoyl-DL-lysine；N²-Benzoyl-DL-lysin；N²-Benzoyl-lysin；6-azaniumyl-2-benzamidohexanoate
• CAS: 116783-33-6
• 化学式: C₁₃H₁₈N₂O₃
• 分子量: 250.298
• InChiKey: IYHOIXNPULYXFO-UHFFFAOYSA-N

物化性质

• 熔点：
  211 °C
• 沸点：
  518.1±45.0 °C(Predicted)
• 密度：
  1.186±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N^α-Benzoyllysine 在 磺酰氯 、 三乙胺 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 22.0h， 生成
  参考文献：
  名称：

  Pedersen, Michelle L.; Berkowitz, David B., Journal of Organic Chemistry, 1993, vol. 58, # 25, p. 6965 - 6975

  摘要：

  DOI：
• 作为产物：
  描述：

  N^α-benzoyl-N^ε-(benzyloxycarbonyl)lysine 在 盐酸 、 钯 作用下， 生成 N^α-Benzoyllysine
  参考文献：
  名称：

  A SYNTHESIS OF HOMOARGININE

  摘要：

  DOI：

  10.1021/jo01228a008

文献信息

• TREATING BLADDER TUMOR CELLS USING FIBRONECTIN ATTACHMENT PROTEIN AS A TARGET
  申请人：Purdue Research Foundation

  公开号：US20170095568A1

  公开（公告）日：2017-04-06

  Composition and methods are disclosed for utilizing microaggregation of FAP-containing complexes to promote their fast internalization. This approach allows the uptake of cytotoxic cargo coupled to either FAP-Antibodies or FAP-liposome complexes by tumor bladder cells. Importantly, this approach is efficient even under serum-free conditions such as the ones found in the lumen of the bladder.

  揭示了利用FAP含有复合物的微聚集来促进其快速内吞的组合物和方法。这种方法允许将细胞毒性货物与FAP抗体或FAP脂质体复合物耦合，被肿瘤膀胱细胞摄取。重要的是，这种方法即使在无血清条件下，如在膀胱腔内发现的条件下，也是高效的。
• Compositions for the delivery of antigens
  申请人：Emisphere Technologies, Inc.

  公开号：US20020001591A1

  公开（公告）日：2002-01-03

  The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.

  本发明涉及用于口服给药抗原的组合物和方法。将抗原和佐剂与酰化氨基酸或多氨基酸，磺化氨基酸或多氨基酸，或其盐结合。
• Composition containing a penem or carbapenem antibiotic
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0178911A2

  公开（公告）日：1986-04-23

  57 Administration of an N-acylated amino acid (ornithine, lysine, phenylglycine or phenylalanine) in association with a penem or carbapenem antibiotic relieves or eliminates the renal problems associated with administration of the antibiotic alone. The amino acid and antibiotic may be formulated together as a composition or administered separately, either simultaneously or sequentially. A pharmaceutical composition may be prepared simply by mixing the two components.

  57 将 N-酰化氨基酸（鸟氨酸、赖氨酸、苯甘氨酸或苯丙氨酸）与培南类或碳青霉烯类抗生素联合给药，可缓解或消除与单独给药抗生素相关的肾脏问题。 氨基酸和抗生素可一起配制成组合物，也可同时或依次单独给药。 只需将两种成分混合即可制备成药物组合物。
• METHOD OF RESOLVING OPTICAL ISOMERS OF AMINO ACID DERIVATIVE
  申请人：TOKUYAMA CORPORATION

  公开号：EP1338588A1

  公开（公告）日：2003-08-27

  Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture with a hydrophilic compound such as β-cyclodextrin having a different affinity to two kinds of the optical isomers described above and then bringing the resulting aqueous solution or aqueous suspension into contact with a hydrophobic substance such as a solid matter subjected on a surface thereof to hydrophobic treatment on the condition that the pH is 3.5 or lower or under the coexistence of ions including an atomic group having hydrophobicity which can be a counter ion for the amino acid derivative described above such as a triethylammonium ion to thereby separate the D type amino acid derivative from the L type amino acid derivative present in the above aqueous solution or aqueous suspension.

  本发明提供了一种光学异构体混合物的分离方法，该方法包括以下步骤：将氨基酸衍生物（如 N-(叔丁氧羰基)-DL-丙氨酸）与亲水性化合物（如对上述两种光学异构体具有不同亲和力的 β-环糊精）混合，在混合物中存在 D 型和 L 型光学异构体。对上述两种光学异构体具有不同亲和力的环糊精的混合物，然后将所得水溶液或水悬浮液与疏水性物质接触，如在其表面进行疏水处理的固体物质，条件是 pH 值为 3.5或更低的pH值，或在包括具有疏水性的原子团的离子共存的条件下，该原子团可以是上述氨基酸衍生物的反离子，例如三乙基铵离子，从而将上述水溶液或水悬浮液中的D型氨基酸衍生物与L型氨基酸衍生物分离。
• METHOD FOR PRODUCING N EPSILON -ACYL-L-LYSINE
  申请人：Ajinomoto Co., Inc.

  公开号：EP3375883A1

  公开（公告）日：2018-09-19

  The present invention provides a method for producing Nε-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of Nε-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing Nε-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of any of the following (A) to (C) proteins to produce Nε-acyl-L-lysine: (A) a protein comprising an amino acid sequence of SEQ ID NO: 1; (B) a protein comprising an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity; and (C) a protein comprising an amino acid sequence having 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having Nε-acyl-L-lysine-specific aminoacylase activity.

  本发明提供了一种利用一种酶生产 Nε-十二碳酰基-L-赖氨酸的方法，该酶具有适于工业生产 Nε-十二碳酰基-L-赖氨酸的特性。更具体地说，本发明提供了一种生产 Nε-酰基-L-赖氨酸的方法，包括在下列(A)至(C)任一蛋白质存在下，使羧酸或其盐和 L-赖氨酸或其盐反应，以生产 Nε-酰基-L-赖氨酸： (A) 包含 SEQ ID NO: 1 氨基酸序列的蛋白质； (B) 包含在 SEQ ID NO: 1 的氨基酸序列中插入、添加、删除或替换了一个或多个氨基酸残基的氨基酸序列并具有 Nε-酰基-L-赖氨酸特异性氨基酰化酶活性的蛋白质；以及 (C) 包含与 SEQ ID NO: 1 的氨基酸序列具有 90% 或更高同源性且具有 Nε-酰基-L-赖氨酸特异性氨 基化酶活性的氨基酸序列的蛋白质。