(E)-1-tert-butyl 5-methyl 2-(diphenylmethyleneamino)-4-(furan-2-ylmethylene)pentanedioate | 1149760-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-1-tert-butyl 5-methyl 2-(diphenylmethyleneamino)-4-(furan-2-ylmethylene)pentanedioate
• 英文别名: 5-O-tert-butyl 1-O-methyl (2E,4S)-4-(benzhydrylideneamino)-2-(furan-2-ylmethylidene)pentanedioate
• CAS: 1149760-10-0
• 化学式: C₂₈H₂₉NO₅
• 分子量: 459.542
• InChiKey: OMBDTMXBSJISAS-HCYCUYITSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-二苯亚甲基-甘氨酸叔丁酯 、 methyl 2-(acetoxy(furan-2-yl)methyl)acrylate 在 tetrakis(acetonitrile)copper(I) perchlorate 、 1-[4(S)-tert-butyl-2-oxazolin-2-yl]-2(S)-(diphenylphosphino)ferrocene 、 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 以96%的产率得到(E)-1-tert-butyl 5-methyl 2-(diphenylmethyleneamino)-4-(furan-2-ylmethylene)pentanedioate
  参考文献：
  名称：

  Highly Enantioselective Cu-Catalyzed Conjugate Addition−Elimination of Activated Allylic Acetates with Glycine Derivatives

  摘要：

  The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.

  DOI：

  10.1021/ol900439h

文献信息

• Highly Enantioselective Cu-Catalyzed Conjugate Addition−Elimination of Activated Allylic Acetates with Glycine Derivatives
  作者：Chun-Gen Chen、Xue-Long Hou、Lin Pu

  DOI：10.1021/ol900439h

  日期：2009.5.21

  The reaction of a glycinate Schiff base with the activated alkyl- and aryl-substituted allylic acetates afforded 4-alkylidenylglutamic acid derivatives in high yields and high enantioselectivities by using Cu/P,N-FcPhox as the catalyst.