2-氯乙基苯基亚砜 | 27998-60-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氯乙基苯基亚砜
• 英文名称: chloroethyl phenyl sulfoxide
• 英文别名: 2-chloroethyl phenyl sulfoxide；((2-chloroethyl)sulfinyl)benzene；1-chloro-2-phenylsulfinylethane；2-Chloroethyl phenyl sulphoxide；2-chloroethylsulfinylbenzene
• CAS: 27998-60-3
• 化学式: C₈H₉ClOS
• mdl: MFCD00040896
• 分子量: 188.678
• InChiKey: XNUCQTSEDXYZCQ-UHFFFAOYSA-N

物化性质

• 熔点：
  31-32 °C
• 沸点：
  330.6±25.0 °C(Predicted)
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/38
• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  2-氯乙基苯基亚砜 在 三氯化锑 二乙胺基三氟化硫 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 Phenyl 2-chloro-1-fluoroethyl sulfide
  参考文献：
  名称：

  Addition of .alpha.-oxy radicals to 1-fluoro-1-phenylsulfonylethylene

  摘要：

  DOI：

  10.1021/jo00296a081
• 作为产物：
  描述：

  苯基乙烯基亚砜 在 三甲基氯硅烷 作用下， 以 氯仿 为溶剂， 反应 0.2h， 以40%的产率得到2-氯乙基苯基亚砜
  参考文献：
  名称：

  An investigation of the behaviour of α,β-unsaturated sulfoxides in the presence of trimethylsilyl iodide

  摘要：

  A mild, efficient and seemingly general method for converting alpha,beta-unsaturated sulfoxides into carbonyl compounds by means of trimethylsilyl iodide (TMSI) is described. Experiments on different substrates and trimethylsilyl halides lead to the conclusion that the oxidation state of the sulfur atom, on one hand, and halogen kind in TMSX on the other, assume a determining role in the progression of the reaction. The ease of experimental procedure, the possibility of H-1 NMR monitoring, and good yields of final products constitute advantages of the TMSI-promoted conversion of alpha,beta-unsaturated sulfoxides into carbonyl compounds. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)01365-0

文献信息

• 2-Iodylphenol Ethers:  Preparation, X-ray Crystal Structure, and Reactivity of New Hypervalent Iodine(V) Oxidizing Reagents
  作者：Alexey Y. Koposov、Rashad R. Karimov、Ivan M. Geraskin、Victor N. Nemykin、Viktor V. Zhdankin

  DOI：10.1021/jo0614947

  日期：2006.10.1

  2-Iodylphenol ethers were prepared by the dimethyldioxirane oxidation of the corresponding 2-iodophenol ethers and isolated as chemically stable, microcrystalline products. Single-crystal X-ray diffraction analysis of 1-iodyl-2-isopropoxybenzene 8c and 1-iodyl-2-butoxybenzene 8d revealed pseudopolymeric arrangements in the solid state formed by intermolecular interactions between IO2 groups of different

  通过相应的2-碘苯酚醚的二甲基二环氧乙烷氧化制备2-碘苯酚醚，并分离为化学稳定的微晶产物。1-碘-2-异丙氧基苯8c和1-碘-2-丁氧基苯8d的单晶X射线衍射分析显示，固态的假聚合物排列是由不同分子的IO 2基团之间的分子间相互作用形成的。2-碘基苯酚醚可以将硫化物选择性氧化为亚砜，将醇选择性氧化为相应的醛或酮。
• Ti(Phen)(OC₂H₅)₂Cl₂: a highly efficient pre-catalyst for selective oxidation of organic sulfides to sulfoxides by hydrogen peroxide
  作者：Rong-Hui Wu、Jing Wu、Ming-Xin Yu、Long-Guan Zhu

  DOI：10.1039/c7ra06883b

  日期：——

  [Ti(Phen)(OC2H5)2Cl2] (Phen = 1,10-phenanthroline) is reported as a homogeneous pre-catalyst for the selective oxidation of organic sulfides to sulfoxides with a stoichiometric amount of 30% aq. H2O2 in CH3OH at room temperature. This catalytic system showed high yield (95–100%) and good selectivity (92–100%) during the catalytic reaction in a short period of time.

  据报道，一种新开发并具有结构特征的钛配合物[Ti（Phen）（OC 2 H 5）2 Cl 2 ]（Phen = 1,10-菲咯啉）是一种均相的预催化剂，可以将有机硫化物选择性氧化为亚砜。化学计量比为30％的水溶液。室温下在CH 3 OH中的H 2 O 2。该催化体系在短时间内的催化反应过程中显示出高收率（95–100％）和良好的选择性（92–100％）。
• Substituted azepino[4,5b] indoline derivatives
  申请人：——

  公开号：US20020077318A1

  公开（公告）日：2002-06-20

  The invention provides compounds of Formula (I): 1 wherein R 1 -R 4 , p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.

  该发明提供了Formula (I)的化合物： 其中R1-R4，p和q的取值如规范中描述的任何值，以及其药用盐，以及含有这种化合物或盐的药用组合物。这些化合物和盐是5-HT配体，对于治疗哺乳动物中涉及5-HT受体活性的疾病、紊乱和/或症状是有用的。这些化合物和盐特别适用于治疗中枢神经系统疾病。
• Tungstate supported mesoporous silica SBA‐15 with imidazolium framework as a hybrid nanocatalyst for selective oxidation of sulfides in the presence of hydrogen peroxide
  作者：Alireza Sedrpoushan、Fereshteh Hosseini‐Eshbala、Farajollah Mohanazadeh、Masoud Heydari

  DOI：10.1002/aoc.4004

  日期：2018.2

  thermogravimetric analysis. The catalyst was also applied to the selective oxidation of various sulfides. The hybrid catalyst was easily recovered, and was very stable and retained good activity for at least five successive runs without any additional activation. Moreover, there was no remarkable decrease in the activity and selectivity of the catalyst. The products could be easily isolated by just removing

  在这项工作中，制备了一种新的非均相催化剂（SBA-15 / Im / WO 4 2-），然后研究了其在有机硫化物氧化中的性能（在中性反应条件下使用30％H 2 O 2作为绿色氧化剂） ）。这种有机-无机杂化介孔材料的特征在于多种技术，例如FT-IR，电感耦合等离子体，X射线粉末衍射，高分辨率透射电子显微镜，N 2吸附-解吸和热重分析。该催化剂还用于各种硫化物的选择性氧化。杂化催化剂易于回收，并且非常稳定并且在至少五个连续运行中保持了良好的活性，而没有任何额外的活化。而且，催化剂的活性和选择性没有明显降低。只需在过滤催化剂后除去溶剂即可轻松分离出产物。通过该催化剂的催化产物的产率为75％至97％。
• A Mild, Inexpensive, and Convenient Synthesis of Sulfoxides by the Oxidation of Sulfides with Calcium Hypochlorite and Moist Alumina
  作者：Masao Hirano、Sigetaka Yakabe、Shikiko Itoh、James H. Clark、Takashi Morimotoa

  DOI：10.1055/s-1997-1330

  日期：1997.10

  The dichloromethane-alumina biphasic system is a simple and effective reagent for the selective oxidation of sulfides to the sulfoxides with calcium hypochlorite.

  二氯甲烷-氧化铝两相体系是一种简便且有效的试剂，用于选择性地将硫化物氧化成亚砜，使用次氯酸钙作为氧化剂。

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