4-(Propane-2-sulfonylamino)-N-(4-trifluoromethyl-phenyl)-benzamide | 90234-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(Propane-2-sulfonylamino)-N-(4-trifluoromethyl-phenyl)-benzamide
• 英文别名: 4-(propan-2-ylsulfonylamino)-N-[4-(trifluoromethyl)phenyl]benzamide
• CAS: 90234-12-1
• 化学式: C₁₇H₁₇F₃N₂O₃S
• 分子量: 386.395
• InChiKey: OBDXOGKRNGPBQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  对三氟甲基苯胺 在 吡啶 、 盐酸 、 tin 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.58h， 生成 4-(Propane-2-sulfonylamino)-N-(4-trifluoromethyl-phenyl)-benzamide
  参考文献：
  名称：

  Synthesis and antiviral activity of sulfonamidobenzophenone oximes and sulfonamidobenzamides

  摘要：

  To find antiviral agents, various sulfonamidobenzophenone oximes (II) were synthesized from the appropriate m-sulfonamidobenzophenones by hydroxylamine reaction. The reaction products were generally obtained as syn/anti mixtures which were separable by fractional crystallization. The anti isomer had more potent antipoliovirus activity than the syn isomer. Various sulfonamidobenzamides (III) which were structurally related to II were synthesized by the reactions of amino-substituted benzamides with sulfuryl chloride or amines with (aminosulfonyl)benzoyl chloride. Antiviral activity was examined by the plaque-inhibition test. Compounds 5, 36, and 69 exhibited strong antipicornavirus activity. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00153a018

文献信息

• NPY Y5 antagonist
  申请人：Kawanishi Yasuyuki

  公开号：US20070015762A1

  公开（公告）日：2007-01-18

  The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R 1 is lower alkyl, cycloalkyl or the like, R 2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR 7 , CSNR 7 , NR 7 CO, NR 7 CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R 7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereof

  本发明提供了一种用作NPY Y5受体拮抗剂的药物组合物，包括公式（I）中的化合物： 其中R1是较低的烷基、环烷基或类似物，R2是氢、较低的烷基或类似物，n为1或2，X为较低的烷基、较低的烯基、芳基、环烷基或类似物，Y为CONR7、CSNR7、NR7CO、NR7CS或类似物，Z为较低的烷基、可选择的取代的碳环烷基、可选择的取代的杂环烷基或类似物，R7为氢或较低的烷基，前药、药学上可接受的盐或溶剂。
• NPY Y5 ANTAGONIST
  申请人：KAWANISHI Yasuyuki

  公开号：US20100292500A1

  公开（公告）日：2010-11-18

  The present invention provides a pharmaceutical composition for use as art NPY Y5 receptor antagonist comprising a compound or the formula (I): wherein R 1 is lower alkyl, cycloalkyl or the like, R 2 is hydrogen, lower alkyl or the like, n is 1 or 2, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, Y is CONR 7 , CSNR 7 , NR 7 CO, NR 7 CS or the like, Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like and R 7 is hydrogen or lower alkyl, prodrug, pharmaceutically acceptable salt or solvate thereof.

  本发明提供了一种药物组合物，用作NPY Y5受体拮抗剂，包括化合物或式（I）：其中R1为低碳基、环烷基或类似物，R2为氢、低碳基或类似物，n为1或2，X为低碳基、低烯基、芳基、环烷基或类似物，Y为CONR7、CSNR7、NR7CO、NR7CS或类似物，Z为低碳基、可选取代的碳环基、可选取代的杂环基或类似物，R7为氢或低碳基，前药、药学上可接受的盐或溶剂。
• US7265130B2
  申请人：——

  公开号：US7265130B2

  公开（公告）日：2007-09-04
• US7781461B2
  申请人：——

  公开号：US7781461B2

  公开（公告）日：2010-08-24
• US8115027B2
  申请人：——

  公开号：US8115027B2

  公开（公告）日：2012-02-14