2-氰基苯甲酰肼 | 19731-00-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-氰基苯甲酰肼
• 中文别名: 2-氰基苯并肼
• 英文名称: o-Cyan-benzoesaeure-hydrazid
• 英文别名: 2-Cyanobenzohydrazide
• CAS: 19731-00-1
• 化学式: C₈H₇N₃O
• mdl: MFCD18071017
• 分子量: 161.163
• InChiKey: TWJNQYPJQDRXPH-UHFFFAOYSA-N

物化性质

• 熔点：
  265-266 °C
• 密度：
  1.28±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.9
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2-氰基苯甲酰肼 在 盐酸 、 potassium carbonate 、 potassium hydroxide 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 反应 8.0h， 生成 2-[5-(3-Bromopropylsulfanyl)-1,3,4-oxadiazol-2-yl]benzonitrile
  参考文献：
  名称：

  Synthesis and evaluation of novel azoles as potent antifungal agents

  摘要：

  Using a rational approach to the design of antifungal agents, a series of azole agents with 1,3,4-oxadiazole side chains were designed and synthesized. The results of preliminary in vitro antifungal tests with eight human pathogenic compounds showed that all of the title compounds exhibited excellent activities against all of the tested fungi except Aspergillus fumigatus. Compounds 11e and 11f were found to be the most effective, with a minimum inhibitory concentration of 0.0039 mu g/mL, followed by voriconazole, which has a MIC of 0.0625 mu g/mL. The 1,3,4-oxadiazole side chain is not the major contributor but plays a role in eliciting the observed antifungal activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.11.037
• 作为产物：
  描述：

  2-氰基苯甲酸甲酯 在 一水合肼 作用下， 以 甲醇 为溶剂， 反应 5.0h， 生成 2-氰基苯甲酰肼
  参考文献：
  名称：

  Synthesis and evaluation of novel azoles as potent antifungal agents

  摘要：

  Using a rational approach to the design of antifungal agents, a series of azole agents with 1,3,4-oxadiazole side chains were designed and synthesized. The results of preliminary in vitro antifungal tests with eight human pathogenic compounds showed that all of the title compounds exhibited excellent activities against all of the tested fungi except Aspergillus fumigatus. Compounds 11e and 11f were found to be the most effective, with a minimum inhibitory concentration of 0.0039 mu g/mL, followed by voriconazole, which has a MIC of 0.0625 mu g/mL. The 1,3,4-oxadiazole side chain is not the major contributor but plays a role in eliciting the observed antifungal activity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.11.037

文献信息

• Synthesis and evaluation of novel azoles as potent antifungal agents
  作者：Liangjing Li、Hao Ding、Baogang Wang、Shichong Yu、Yan Zou、Xiaoyun Chai、Qiuye Wu

  DOI：10.1016/j.bmcl.2013.11.037

  日期：2014.1

  Using a rational approach to the design of antifungal agents, a series of azole agents with 1,3,4-oxadiazole side chains were designed and synthesized. The results of preliminary in vitro antifungal tests with eight human pathogenic compounds showed that all of the title compounds exhibited excellent activities against all of the tested fungi except Aspergillus fumigatus. Compounds 11e and 11f were found to be the most effective, with a minimum inhibitory concentration of 0.0039 mu g/mL, followed by voriconazole, which has a MIC of 0.0625 mu g/mL. The 1,3,4-oxadiazole side chain is not the major contributor but plays a role in eliciting the observed antifungal activity. (C) 2013 Elsevier Ltd. All rights reserved.