phenyl-[4]piperidyl-methanol; hydro chloride | 91688-34-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: phenyl-[4]piperidyl-methanol; hydro chloride
• 英文别名: Phenyl-[4]piperidyl-methanol; Hyrochlorid；Phenyl(piperidin-4-yl)methanol hydrochloride；phenyl(piperidin-4-yl)methanol;hydrochloride
• CAS: 91688-34-5
• 化学式: C₁₂H₁₇NO*ClH
• 分子量: 227.734
• InChiKey: PPGWNDJNKZGIRG-UHFFFAOYSA-N

物化性质

• 熔点：
  191-193 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-苯甲酰吡啶 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 、 1,2-二氯乙烷 为溶剂， 25.0 ℃ 、275.8 kPa 条件下， 反应 23.0h， 生成 phenyl-[4]piperidyl-methanol; hydro chloride 、 4-(苯基甲基)-哌啶盐酸盐
  参考文献：
  名称：

  Controlling chemoselective transformations of 4-acylpyridines via a Pd–C catalytic hydrodechlorination–hydrogenation

  摘要：

  A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and alpha-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of CICH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.12.017

文献信息

• Controlling chemoselective transformations of 4-acylpyridines via a Pd–C catalytic hydrodechlorination–hydrogenation
  作者：Chuanjie Cheng、Bo Wang、Nan Liu、Wenwen Chen、Xinyan Wang、Yuefei Hu

  DOI：10.1016/j.tet.2013.12.017

  日期：2014.1

  A novel Pd-C catalytic hydrodechlorination-hydrogenation was developed for a multi-step one-pot transformation of 4-acylpyridines. Under the selected conditions, 4-benzoylpyridines and 4-alkanoylpyridines were chemoselectively converted into the corresponding 4-benzylpiperidine hydrochlorides and alpha-alkyl-4-piperidinemethanol hydrochlorides, respectively. This catalytic method was performed simply by an addition of 1 equiv of CICH2CHCl2 to the conventional hydrogenation system and directly gave the crystalline piperidine hydrochlorides in practical quantitative yields. (C) 2013 Elsevier Ltd. All rights reserved.