N-methyl-2-hydroxy-2-(4'-nitrophenyl)ethylamine | 61192-64-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-2-hydroxy-2-(4'-nitrophenyl)ethylamine
• 英文别名: 2-(methylamino)-1-(4-nitrophenyl)ethanol；2-methylamino-1-(4-nitro-phenyl)-ethanol；2-Methylamino-1-(4-nitro-phenyl)-aethanol；rac-2-(methylamino)-1-(4-nitrophenyl)ethanol；1-(4-nitro-phenyl)-2-methylaminoethanol；2-Methylamino-1-<4-nitro-phenyl>-aethan-1-ol；2-(Methylamino)-1-(4-nitrophenyl)ethan-1-ol
• CAS: 61192-64-1
• 化学式: C₉H₁₂N₂O₃
• mdl: MFCD00193247
• 分子量: 196.206
• InChiKey: CCRPAZWXXRIRRS-UHFFFAOYSA-N

物化性质

• 沸点：
  362.9±32.0 °C(Predicted)
• 密度：
  1.244±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-methyl-2-hydroxy-2-(4'-nitrophenyl)ethylamine 生成 1-Methyl-2-(4-nitro-phenyl)-aziridine
  参考文献：
  名称：

  Relative conjugative abilities of three-membered-ring heterocycles with benzene based on carbon-13 and nitrogen-15 NMR

  摘要：

  DOI：

  10.1021/ja00351a002
• 作为产物：
  描述：

  2-溴-4'-硝基苯乙酮 在 sodium tetrahydroborate 作用下， 以 水 为溶剂， 生成 N-methyl-2-hydroxy-2-(4'-nitrophenyl)ethylamine
  参考文献：
  名称：

  Relative conjugative abilities of three-membered-ring heterocycles with benzene based on carbon-13 and nitrogen-15 NMR

  摘要：

  DOI：

  10.1021/ja00351a002

文献信息

• [EN] ARYL-ETHANOLAMINE DERIVATIVES AS ANTIVIRAL AGENTS<br/>[FR] DERIVES D'ARYL-ETHANOLAMINE EN TANT QU'AGENTS ANTIVIRAUX
  申请人：UPJOHN CO

  公开号：WO2004022568A1

  公开（公告）日：2004-03-18

  The present invention provides a compound of formula as describedherein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种如下所述的化合物，该化合物可用作抗病毒剂，特别是用作抗疱疹病毒家族的药剂。
• A simple two-step synthesis of 2-(alkylamino)-1-arylethanols, including racemic adrenaline, from aromatic aldehydes via 5-aryloxazolidines
  作者：Vladimir S. Moshkin、Vyacheslav Ya. Sosnovskikh

  DOI：10.1016/j.tetlet.2013.08.083

  日期：2013.10

  Benzaldehydes react smoothly with nonstabilized azomethine ylides, generated in situ from sarcosine/formaldehyde or N-(methoxymethyl)-N-(trimethylsilylmethyl)benzylamine, to give 5-aryloxazolidines as intermediates. These were converted into 2-(alkylamino)-1-arylethanols in good yields by simple heating in methanol with hydrochloric acid, or by treatment with hydrazine hydrate in ethanol.

  苯甲醛与由肌氨酸/甲醛或N-（甲氧基甲基）-N-（三甲基甲硅烷基甲基）苄胺原位生成的不稳定的甲亚胺基化物平稳反应，生成5-芳基恶唑烷作为中间体。通过简单地在甲醇中用盐酸加热，或通过在乙醇中用水合肼处理，将它们高产率地转化为2-（烷基氨基）-1-芳基乙醇。
• Aryl-ethanolamine derivatives as antiviral agents
  申请人：——

  公开号：US20040116464A1

  公开（公告）日：2004-06-17

  The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.

  本发明提供了一种如下式所述的化合物，其作为抗病毒剂特别是对抗疱疹病毒家族的病毒具有用处。
• COMPOUNDS BASED ON PALLADIUM AND ON DERIVATIVES OF AROMATIC AMINES AND METHOD OF OBTAINING THEM
  申请人：EFIMENKO, Inessa Alexandrovna

  公开号：EP0603412A1

  公开（公告）日：1994-06-29

  New compounds are proposed based on palladium and on derivatives of aromatic amines of the following general formula (I): [NH₂R₁R₂]₂PdCl₄ in which R₁ is a group with formula (II) where Y= H; OH; NO₂; X₁ = H; OH; X₂ = OH; CH₃; X₃ = H; CH₃; CH₂OH; and R₂ = CH₃; C₂H₅, having radiomodifying activity and capable of being used in medicine. The compounds are effective to be introduced in the organism both before and after gamma radiation, as well as at chronic radiations with small doses. A method of obtaining the claimed compounds is also proposed.

  提出了以钯和下列通式 (I) 的芳香胺衍生物为基础的新化合物：[NH₂R₁R₂]₂PdCl₄，其中 R₁ 是式 (II) 的基团 Y= H；OH；NO₂；X₁ = H；OH；X₂ = OH；CH₃；X₃ = H；CH₃；CH₂OH；以及 R₂ = CH₃；C₂H₅，具有放射性调节活性，可用于医药。这些化合物可以在伽马射线辐射前后以及小剂量慢性辐射时有效地进入机体。此外，还提出了一种获得所述化合物的方法。
• DE521729
  申请人：——

  公开号：——

  公开（公告）日：——