N'-[4-Anilino-6-(2-pyridylamino)-1,3,5-triazin-2-yl]pyridine-4-carbohydrazide | 1221231-45-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N'-[4-Anilino-6-(2-pyridylamino)-1,3,5-triazin-2-yl]pyridine-4-carbohydrazide
• 英文别名: N'-[4-anilino-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl]pyridine-4-carbohydrazide
• CAS: 1221231-45-3
• 化学式: C₂₀H₁₇N₉O
• 分子量: 399.415
• InChiKey: WQTSIQXRWTVAOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (dichloro-[1,3,5]triazin-2-yl)-[2]pyridyl-amine 以 1,4-二氧六环 、 水 、 丙酮 为溶剂， 生成 N'-[4-Anilino-6-(2-pyridylamino)-1,3,5-triazin-2-yl]pyridine-4-carbohydrazide
  参考文献：
  名称：

  In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide

  摘要：

  A variety of N'-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide, 7a-r were synthesized by using 2-aminopyridine, isonicotic acid hydrazide and cyanuric chloride, and the structures of these compounds were confirmed by IR and NMR (H-1 and C-13) spectral analyses. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system.

  DOI：

  10.1007/s00044-010-9324-3

文献信息

• In vitro antimycobacterial activity of novel N′-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide
  作者：Jignesh Priyakant Raval、Nilesh Hasmukhbhai Patel、Hemul Vinubhai Patel、Pradip Shantibhai Patel

  DOI：10.1007/s00044-010-9324-3

  日期：2011.4

  A variety of N'-(4-(substituted phenyl amino)-6-(pyridin-2-ylamino)-1,3,5-triazin-2-yl)isonicotinohydrazide, 7a-r were synthesized by using 2-aminopyridine, isonicotic acid hydrazide and cyanuric chloride, and the structures of these compounds were confirmed by IR and NMR (H-1 and C-13) spectral analyses. Newly synthesized compounds were tested for their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system.