1-(3-hydroxy-4-methy)lbenzenesulfonyl-1H-indole | 1078790-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-hydroxy-4-methy)lbenzenesulfonyl-1H-indole
• 英文别名: 5-Indol-1-ylsulfonyl-2-methylphenol
• CAS: 1078790-37-0
• 化学式: C₁₅H₁₃NO₃S
• 分子量: 287.339
• InChiKey: JSCVMQUNHRFUFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(3-hydroxy-4-methy)lbenzenesulfonyl-1H-indole 、 N,N-二甲基-3-氯丙胺 在 potassium carbonate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 0.33h， 生成 1-[4'-methyl-3'-(N,N-dimethylaminopropoxy)benzenesulfonyl]-1H-indole
  参考文献：
  名称：

  WO2008/136017

  摘要：

  公开号：

文献信息

• AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS
  申请人：Ramakrishna Nirogi

  公开号：US20100087484A1

  公开（公告）日：2010-04-08

  The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT 6 receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.

  本发明涉及公式（I）的新型氨基烷氧基芳磺酰胺化合物，其衍生物，对映异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物。本发明还涉及制备上述新化合物，其衍生物，对映异构体，其药学上可接受的盐和含有它们的药学上可接受的组合物的方法。这些化合物在治疗与5-HT6受体功能相关的各种疾病方面非常有用。具体而言，本发明的化合物还可用于治疗各种中枢神经系统疾病，血液学疾病，进食障碍，与疼痛相关的疾病，呼吸系统疾病，泌尿生殖系统疾病，心血管疾病和癌症。
• US8003670B2
  申请人：——

  公开号：US8003670B2

  公开（公告）日：2011-08-23
• [EN] AMINOALKOXY ARYL SULFONAMIDE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS<br/>[FR] COMPOSÉS AMINOALCOXY ARYL SULFONAMIDES ET LEUR UTILISATION EN TANT QUE LIGANDS 5-HT6
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2008136017A1

  公开（公告）日：2008-11-13

  [EN] The present invention relates to novel aminoalkoxy arylsulfonamide compounds of the formula (I), their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, their derivatives, their stereoisomers, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. These compounds are useful in the treatment of various disorders that are related to 5-HT₆ receptor functions. Specifically, the compounds of this invention are also useful in the treatment of various CNS disorders, hematological disorders, eating disorders, diseases associated with pain, respiratory diseases, genito-urological disorders, cardiovascular diseases and cancer.
  [FR] La présente invention concerne de nouveaux composés aminoalcoxy arylsulfonamides de la formule (I), leurs dérivés, leurs stéréo-isomères, leurs sels acceptables du point de vue pharmaceutique et des compositions acceptables du point de vue pharmaceutique les contenant. La présente invention concerne également un procédé pour la préparation desdits nouveaux composés ci-dessus, de leurs dérivés, de leurs stéréo-isomères, de leurs sels acceptables du point de vue pharmaceutique et des compositions acceptables du point de vue pharmaceutique les contenant. Ces composés s'utilisent dans le traitement de divers troubles qui sont associés à des fonctions du récepteur 5-HT₆. De façon précise, les composés de cette invention s'utilisent également dans le traitement de divers troubles du système nerveux central, hématologiques, de l'alimentation, génito-urologiques, ainsi que dans le traitement de maladies associées à la douleur, de maladies respiratoires, de maladies cardiovasculaires et du cancer.
• WO2008/136017
  申请人：——

  公开号：——

  公开（公告）日：——