6-(Ethylamino)pyridazin-3(2H)-one | 88259-78-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(Ethylamino)pyridazin-3(2H)-one
• 英文别名: 3-(ethylamino)-1H-pyridazin-6-one
• CAS: 88259-78-3
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: RLNFWFBMYVHVHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(Ethylamino)pyridazin-3(2H)-one 生成 6-diethoxyphosphinothioyloxy-N-ethylpyridazin-3-amine
  参考文献：
  名称：

  OKADA, IOSIYUKI;SATO, YASUO;KAMEHI, KADZUO

  摘要：

  DOI：

文献信息

• [EN] ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME<br/>[FR] COMPOSÉS ANTIMICROBIENS ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI
  申请人：MELINTA THERAPEUTICS INC

  公开号：WO2016145417A1

  公开（公告）日：2016-09-15

  The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.

  本公开涉及抗微生物化合物领域，以及制备和使用这些化合物的方法。这些化合物可用于治疗、预防、降低人类和动物微生物感染的风险，并延缓感染的发生。
• OKADA, IOSIYUKI;SATO, YASUO;KAMEHI, KADZUO
  作者：OKADA, IOSIYUKI、SATO, YASUO、KAMEHI, KADZUO

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR GENOMIC TARGET ENRICHMENT AND SELECTIVE DNA SEQUENCING
  申请人：PetaOmics, Inc.

  公开号：US20210332413A1

  公开（公告）日：2021-10-28

  It has been established that one or more large double stranded DNA fragments (each 2,000 to 40,000 base pairs in size) can be captured and isolated from genomic DNA fragments using sequence specific PNA hybridization probes. Compositions and methods for enrichment of a multiplicity of long DNA sequences selected from the genome of any eukaryote are provided. Capture is performed using multiple PNA molecules with gamma-modified chiral backbones, comprising a mixture of neutral and positive chemical groups. Two or more PNA probes with covalently bound haptens, preferably biotin, target each DNA domain of interest for capture, isolation, and subsequent sequencing analysis of the multiplicity of enriched targets, including DNA methylation sequencing. The methods include enhancement of probe-DNA binding specificity through single strand binding proteins (SSB).