2-溴-5-(羟基甲基)-1,3-苯二酚 | 692205-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-溴-5-(羟基甲基)-1,3-苯二酚
• 英文名称: 4-bromo-3,5-dihydroxybenzyl alcohol
• 英文别名: 2-Bromo-5-(hydroxymethyl)benzene-1,3-diol
• CAS: 692205-49-5
• 化学式: C₇H₇BrO₃
• 分子量: 219.035
• InChiKey: BDMHLKRVKAXOLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  361.7±37.0 °C(Predicted)
• 密度：
  1.883±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-溴-5-(羟基甲基)-1,3-苯二酚 在 N-溴代丁二酰亚胺(NBS) 、 18-冠醚-6 、 dimethyl sulfide borane 、 sodium hydride 、 potassium carbonate 、 三苯基膦 、 potassium iodide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 38.0h， 生成 3-{3-(4-Bromo-benzyloxy)-5-[2-(2-methyl-benzyloxy)-ethoxy]-benzyloxymethyl}-5-{2-[2-bromo-3-decyloxy-5-(naphthalen-2-ylmethoxymethyl)-phenoxy]-ethoxy}-benzoic acid ethyl ester
  参考文献：
  名称：

  树突和树状聚合物中的序列

  摘要：

  各种官能团的顺序结合形成了生物大分子中特异性的基础。在人工大分子中引入这种多样性和测序能力从根本上是有趣的。在本文中，已使用三种不同的合成方法来构建树枝状聚合物和树枝状聚合物，其中所有单体单元互不相同。本文所述的合成策略涉及使用（i）ABB p单体，（ii）ABB'单体和（iii）ABB m单体。这些合成方法的互补性和多功能性应使其在各种应用中有用。

  DOI：

  10.1021/jo049878p
• 作为产物：
  描述：

  4-溴-3,5-二羟基苯甲酸 在 乙醇 、 硫酸 、 dimethyl sulfide borane 作用下， 生成 2-溴-5-(羟基甲基)-1,3-苯二酚
  参考文献：
  名称：

  Site-Specific Installation and Study of Electroactive Units in Every Layer of Dendrons

  摘要：

  Whereas encapsulation of functional groups at the core of dendrimers is well-understood, very little is known about their intermediate layers or even the periphery. Here we report oil a systematic investigation of every layer of dendrimers by incorporating a single ferrocene unit in well-defined locations in dendrons. Site-specific incorporation of the ferrocene unit was achieved by utilizing the dendrimer sequencing methodology. We show here that the redox potential values of ferrocene at intermediate layers were remarkably different from those at the core and the periphery. Although redox potential values were location-dependent, no significant change in the rate of heterogeneous electron transfer (k(0)) was observed with respect to locations. This was attributed to the possibility that free rotation of dendrimer nullifies the distance between the electrode and ferrocene unit. Finally, we also show that no Faradaic current was observed for the amphiphilic assemblies of these dendrons, whereas the same dendron did exhibit significant Faradaic current in nonassembling solvent environments.

  DOI：

  10.1021/jo902109u

文献信息

• Site-Specific Installation and Study of Electroactive Units in Every Layer of Dendrons
  作者：Malar A. Azagarsamy、Kothandam Krishnamoorthy、Kulandaivelu Sivanandan、S. Thayumanavan

  DOI：10.1021/jo902109u

  日期：2009.12.18

  Whereas encapsulation of functional groups at the core of dendrimers is well-understood, very little is known about their intermediate layers or even the periphery. Here we report oil a systematic investigation of every layer of dendrimers by incorporating a single ferrocene unit in well-defined locations in dendrons. Site-specific incorporation of the ferrocene unit was achieved by utilizing the dendrimer sequencing methodology. We show here that the redox potential values of ferrocene at intermediate layers were remarkably different from those at the core and the periphery. Although redox potential values were location-dependent, no significant change in the rate of heterogeneous electron transfer (k(0)) was observed with respect to locations. This was attributed to the possibility that free rotation of dendrimer nullifies the distance between the electrode and ferrocene unit. Finally, we also show that no Faradaic current was observed for the amphiphilic assemblies of these dendrons, whereas the same dendron did exhibit significant Faradaic current in nonassembling solvent environments.
• Sequences in Dendrons and Dendrimers
  作者：Kulandaivelu Sivanandan、Britto S. Sandanaraj、S. Thayumanavan

  DOI：10.1021/jo049878p

  日期：2004.4.1

  incorporation of a variety of functional groups forms the basis for specificity in biomacromolecules. Introduction of such diversity and sequencing ability in artificial macromolecules is fundamentally interesting. In this paper, three different synthetic approaches have been used to build dendrons and dendrimers in which all the monomer units are different from each other. The synthetic strategies described

  各种官能团的顺序结合形成了生物大分子中特异性的基础。在人工大分子中引入这种多样性和测序能力从根本上是有趣的。在本文中，已使用三种不同的合成方法来构建树枝状聚合物和树枝状聚合物，其中所有单体单元互不相同。本文所述的合成策略涉及使用（i）ABB p单体，（ii）ABB'单体和（iii）ABB m单体。这些合成方法的互补性和多功能性应使其在各种应用中有用。