2-chloro-6-fluoro-phenylacetyl chloride | 179314-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-6-fluoro-phenylacetyl chloride
• 英文别名: 2-(2-Chloro-6-fluorophenyl)acetyl chloride
• CAS: 179314-61-5
• 化学式: C₈H₅Cl₂FO
• 分子量: 207.032
• InChiKey: UWZFOGRTURIZSK-UHFFFAOYSA-N

物化性质

• 沸点：
  249.6±30.0 °C(Predicted)
• 密度：
  1.409±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-6-fluoro-phenylacetyl chloride 在 甲酸铵 、 锌 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 8.0h， 生成 1-amino-2-(2-chloro-6-fluorophenyl)ethylphosphonic acid
  参考文献：
  名称：

  氟苯基丙氨酸作为人和猪氨基肽酶N的抑制剂的膦酸类似物：芳香环取代重要性的验证。

  摘要：

  合成了在芳环上被氟，氯和三氟甲基取代的苯丙氨酸的膦酸类似物文库，并评估了其对人（hAPN）和猪（pAPN）氨基肽酶的抑制活性。荧光筛查表明，这些类似物是微摩尔或亚微摩尔抑制剂，两种酶对hAPN的活性更高。为了更好地了解最具活性的化合物的作用方式，使用了分子模型。已经证实，在所有研究的化合物中，酶的氨基膦酸部分几乎相同地结合，而活性的差异是由抑制剂的芳族侧链的位置引起的。有趣的是，单个化合物的两种对映异构体通常非常相似地结合。

  DOI：

  10.3390/biom10040579
• 作为产物：
  描述：

  2-氯-6-氟苯乙酸 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 生成 2-chloro-6-fluoro-phenylacetyl chloride
  参考文献：
  名称：

  氟苯基丙氨酸作为人和猪氨基肽酶N的抑制剂的膦酸类似物：芳香环取代重要性的验证。

  摘要：

  合成了在芳环上被氟，氯和三氟甲基取代的苯丙氨酸的膦酸类似物文库，并评估了其对人（hAPN）和猪（pAPN）氨基肽酶的抑制活性。荧光筛查表明，这些类似物是微摩尔或亚微摩尔抑制剂，两种酶对hAPN的活性更高。为了更好地了解最具活性的化合物的作用方式，使用了分子模型。已经证实，在所有研究的化合物中，酶的氨基膦酸部分几乎相同地结合，而活性的差异是由抑制剂的芳族侧链的位置引起的。有趣的是，单个化合物的两种对映异构体通常非常相似地结合。

  DOI：

  10.3390/biom10040579

文献信息

• [EN] CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS<br/>[FR] (AZA)INDOLIZINE-CARBOXAMIDES CYCLIQUES, LEUR PRÉPARATION ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES
  申请人：SANOFI AVENTIS

  公开号：WO2011012538A1

  公开（公告）日：2011-02-03

  The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib, (Ia) (Ib) wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they inhibit the enzyme renin and modulate the activity of the renin-angiotensin system, and are useful for the treatment of diseases such as hypertension, for example. The invention furthermore relates to processes for the preparation of the compounds of the formulae Ia and Ib, their use and pharmaceutical compositions comprising them.

  本发明涉及公式Ia和Ib的环式吲哚啉羧酰胺和氮杂吲哚啉羧酰胺，其中R、Ra、R10、R20、R30、R40、Y、n、p和q的含义如索赔中所示，它们是有价值的药用活性化合物。具体来说，它们抑制酶肾素并调节肾素-血管紧张素系统的活性，对于治疗高血压等疾病是有用的。此外，本发明还涉及制备公式Ia和Ib化合物的方法、它们的用途以及包含它们的药物组合物。
• Synthesis of 1-mono- and 1,2-bisacylpyrazolidines and 1-arylsulfonylpyrazolines
  作者：V. Yu. Petukhova、V. A. Maslennikov、V. V. Kuznetsov、N. N. Makhova、S. A. Serkov

  DOI：10.1007/s11172-010-0257-2

  日期：2010.7

  Study of a reaction of 1,5-diazabicyclo[3.1.0]hexanes with acyl and sulfonyl chlorides in organic or aqueous organic media in the presence of inorganic bases resulted in development of new simple one-step methods for the preparation of 1-mono- and 1,2-bisacylpyrazolidines and 1-arylsulfonylpyrazolines.

  通过对 1,5-二氮杂双环[3.1.0]己烷与酰基和磺酰基氯在有机或含水有机介质中在无机碱存在下的反应的研究，开发出了一步法制备 1-单酰基和 1,2-双酰基吡唑烷和 1-芳基磺酰基吡唑烷的新的简单方法。
• [EN] FUNGICIDES BASED ON NITROGEN-CONTAINING HETEROCYCLES<br/>[FR] FONGICIDES A BASE D'HETEROCYCLES CONTENANT DE L'AZOTE
  申请人：SYNGENTA LTD

  公开号：WO2004056829A1

  公开（公告）日：2004-07-08

  Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR8; R8 is H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio or halo(C1-4)alkyl; R and R2 are independently H, halo, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylthio, C2-8 alkenyl, C2-8 alkynyl, cyano or NR3R4, provided that at least one of R and R2 is NR3R4; R1 is halo, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)­-alkyl, C1-8 alkoxy, C1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C1-4)alkyl, aryl(C1-4)alkoxy, heteroaryl(C1-4)alkyl, heteroaryl­(C1-4)alkoxy, aryl(C1-4)alkylthio, heteroaryl(C1-4)alkylthio, morpholino, piperidino or pyrrolidino; R3 and R4 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)­- alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl, heteroaryl(C1-8)alkyl, NR5R6, provided that not both R3 and R4 are H or NR5R6, or R3 and R4 together form a C3-7 alkylene or C3-7 alkenylene chain optionally substituted with one or more C1-4 alkyl or C1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R3 and R4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C1-4)alkyl (especially N-methyl) ring; and R5 and R6 are independently H, C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, aryl, aryl(C1-8)­alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-8)alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R8) being optionally substituted with halogen, cyano, C1-6 alkoxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 haloalkoxy, C1-6 alkylthio, tri(C1-4)alkylsilyl, C1-6 alkylamino or C1-6 dialkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C2-6 alkenyloxy, C2-6 alkynyloxy, halo(C1-6)alkyl, halo(C1-6)alkoxy, C1-6 alkylthio, halo(C1-6)alkylthio, hydroxy(C1-6)alkyl, C1-4 alkoxy(C1-6)alkyl, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, -NR''R'', NHCOR'', -NHCONR''R'', -CONR''R'', -SO2R'', -OSO2R'', -COR'', -CR''=NR'' or -N=CR ''R'', in which R'' and R'' are independently hydrogen, C1-4 alkyl, halo-(C1-4)alkyl, C1-4 alkoxy, halo(C1-4)alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl(C1-4)alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy.

  具有通式（1）的杀真菌化合物：式（1）其中W，Z和X和Y中的另一个是N，另一个是CR8；R8是H，卤素，C1-4烷基，C1-4烷氧基，C1-4烷基硫基或卤代（C1-4）烷基；R和R2独立地是H，卤素，C1-8烷基，C1-8烷氧基，C1-8烷基硫基，C2-8烯基，C2-8炔基，氰基或NR3R4，但至少其中之一是NR3R4；R1是卤素，C1-8烷基，C2-8烯基，C2-8炔基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，C1-8烷氧基，C1-8烷基硫基，芳基，芳氧基，芳硫基，杂芳基，杂芳氧基，杂芳硫基，芳基（C1-4）烷基，芳基（C1-4）烷氧基，杂芳基（C1-4）烷基，杂芳基（C1-4）烷氧基，芳基（C1-4）烷基硫基，杂芳基（C1-4）烷基硫基，吗啉基，哌啶基或吡咯啉基；R3和R4独立地是H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，杂芳基，杂芳基（C1-8）-烷基，NR5R6，但不是R3和R4都是H或NR5R6，或R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地用一个或多个C1-4烷基或C1-4烷氧基取代，或与它们所连接的氮原子一起，R3和R4形成吗啉，硫吗啉，硫吗啉S-氧化物或硫吗啉S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（特别是N-甲基）环；R5和R6独立地是H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，杂芳基或杂芳基（C1-8）-烷基；任何上述烷基，烯基，炔基或环烷基基团（R8除外）可选择地用卤素，氰基，C1-6烷氧基，C1-6烷基羰基，C1-6烷氧羰基，C1-6卤代烷氧基，C1-6烷基硫基，三（C1-4）烷基硅烷基，C1-6烷基氨基或C1-6二烷基氨基取代，上述任何吗啉，硫吗啉，哌啶，哌嗪和吡咯啉环可选择地用C1-4烷基（特别是甲基）取代，上述任何芳基或杂芳基基团可选择地用一个或多个取代基取代，所述取代基选择自卤素，羟基，硫醇基，C1-6烷基，C2-6烯基，C2-6炔基，C1-6烷氧基，C2-6烯氧基，C2-6炔氧基，卤代（C1-6）烷基，卤代（C1-6）烷氧基，C1-6烷基硫基，卤代（C1-6）烷基硫基，羟基（C1-6）烷基，C1-4烷氧基（C1-6）烷基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯氧基，苄氧基，苯甲酰氧基，氰基，异氰酸基，硫氰酸基，异硫氰酸基，硝基，-NR''R''，NHCOR''，-NHCONR''R''，-CONR''R''，-SO2R''，-OSO2R''，-COR''，-CR''=NR''或-N=CR''R''，其中R''和R''独立地是氢，C1-4烷基，卤代（C1-4）烷基，C1-4烷氧基，卤代（C1-4）烷氧基，C1-4烷基硫基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯基或苄基，苯基和苄基可选择地用卤素，C1-4烷基或C1-4烷氧基取代。
• Fungicides based on nitrogen-containing heterocycles
  申请人：Crowley Jelf Patrick

  公开号：US20060100203A1

  公开（公告）日：2006-05-11

  Fungicidal compounds having the general formula (1): formula (1) wherein W, Z and one of X and Y are N and the other one of X and Y is CR 8 ; R 8 is H, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio or halo(C 1-4 )alkyl; R and R 2 are independently H, halo, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio, C 2-8 alkenyl, C 2-8 alkynyl, cyano or NR 3 R 4 , provided that at least one of R and R 2 is NR 3 R 4 ; R 1 is halo, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )-alkyl, C 1-8 alkoxy, C 1-8 alkylthio, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio, aryl(C 1-4 )alkyl, aryl(C 1-4 )alkoxy, heteroaryl(C 1-4 )alkyl, heteroaryl(C 1-4 )alkoxy, aryl(C 1-4 )alkylthio, heteroaryl(C 1-4 )alkylthio, morpholino, piperidino or pyrrolidino; R 3 and R 4 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, aryl(C 1-8 )-alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl, heteroaryl(C 1-8 )alkyl, NR 5 R 6 , provided that not both R 3 and R 4 are H or NR 5 R 6 , or R 3 and R 4 together form a C 3-7 alkylene or C 3-7 alkenylene chain optionally substituted with one or more C 1-4 alkyl or C 1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R 3 and R 4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N-(C 1-4 )alkyl (especially N-methyl) ring; and R 5 and R 6 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 -alkynyl, aryl, aryl(C 1-8 )alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-8 )alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R 8 ) being optionally substituted with halogen, cyano, C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 haloalkoxy, C 1-6 alkylthio, tri(C 1-4 )alkylsilyl, C 1-6 alkylamino or C 1-6 dialkylamino, any of the foregoing morpholine, thiomopholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C 1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo(C 1-6 )alkyl, halo(C 1-6 )alkoxy, C 1-6 alkylthio, halo(C 1-6 )alkylthio, hydroxy(C 1-6 )alkyl, C 1-4 alkoxy(C 1-6 )alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NR″′R″″, NHCOR″′, —NHCONR″′R″″, —CONR″′R″″, —SO 2 R″′, —OSO 2 R″′, —COR″′, —CR″′═NR″″ or —N═CR ″′R″″, in which R″′ and R″″ are independently hydrogen, C 1-4 alkyl, halo(C 1-4 )alkyl, C 1-4 alkoxy, halo(C 1-4 )alkoxy, C 1-4 alkylthio, C 3-6 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenyl or benzyl, the phenyl and benzyl groups being optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy.

  具有通式（1）的杀菌化合物：通式（1）其中，W，Z和X和Y中的另一个是CR8，另一个是N；R8为H，卤素，C1-4烷基，C1-4烷氧基，C1-4烷硫基或卤素（C1-4）烷基；R和R2独立地为H，卤素，C1-8烷基，C1-8烷氧基，C1-8烷硫基，C2-8烯基，C2-8炔基，氰基或NR3R4，但其中至少一个为NR3R4；R1为卤素，C1-8烷基，C2-8烯基，C2-8炔基，C3-8环烷基，C3-8环烷基（C1-6）-烷基，C1-8烷氧基，C1-8烷硫基，芳基，芳氧基，芳硫基，杂环芳基，杂环芳氧基，杂环芳硫基，芳基（C1-4）烷基，芳基（C1-4）烷氧基，杂环芳基（C1-4）烷基，杂环芳基（C1-4）烷氧基，芳基（C1-4）烷硫基，杂环芳基（C1-4）烷硫基，吗啉基，哌啶基或吡咯烷基；R3和R4独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基，杂环芳基（C1-8）烷基，NR5R6，但不是R3和R4都为H或NR5R6，或者R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地取代一个或多个C1-4烷基或C1-4烷氧基，或者与它们所附着的氮原子一起，R3和R4形成吗啉，硫代吗啉，硫代吗啉S-氧化物或硫代吗啉S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（特别是N-甲基）环；R5和R6独立地为H，C1-8烷基，C2-8烯基，C2-8炔基，芳基，芳基（C1-8）-烷基，C3-8环烷基，C3-8环烷基（C1-6）烷基，杂环芳基或杂环芳基（C1-8）烷基；除R8之外的任何上述烷基，烯基，炔基或环烷基基团（均可选择地取代卤素，氰基，C1-6烷氧基，C1-6烷基羰基，C1-6烷氧羰基，C1-6卤烷氧基，C1-6烷硫基，三（C1-4）烷基硅烷基，C1-6烷基氨基或C1-6二烷基氨基），任何上述吗啉，硫代吗啉，哌嗪，哌嗪和吡咯烷环可选择地取代C1-4烷基（特别是甲基），任何上述芳基或杂环芳基基团可选择地取代一个或多个取代基，所述取代基选自卤素，羟基，巯基，C1-6烷基，C2-6烯基，C2-6炔基，C1-6烷氧基，C2-6烯氧基，C2-6炔氧基，卤素（C1-6）烷基，卤素（C1-6）烷氧基，C1-6烷硫基，卤素（C1-6）烷硫基，羟基（C1-6）烷基，C1-4烷氧基（C1-6）烷基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯氧基，苄氧基，苯甲酰氧基，氰基，异氰基，硫氰酸基，异硫氰酸基，硝基，—NR″′R″″，NHCOR″′，—NHCONR″′R″″，—CONR″′R″″，—SO2R″′，—OSO2R″′，—COR″′，—CR″′═NR″″或—N═CR″′R″″，其中R″′和R″″独立地为氢，C1-4烷基，卤素（C1-4）烷基，C1-4烷氧基，卤素（C1-4）烷氧基，C1-4烷硫基，C3-6环烷基，C3-6环烷基（C1-4）烷基，苯基或苄基，苯基和苄基可选择地取代卤素，C1-4烷基或C1-4烷氧基。
• Fungicides
  申请人：Crowley Jelf Patrick

  公开号：US20060069089A1

  公开（公告）日：2006-03-30

  Fungicidal compositions of the general formula (1): wherein one of W, X, Y and Z is N and the others are CR 8 ; R 8 is H, halo, C 1-4 alkyl, C 1-4 alkoxy or halo(C 1-4 )alkyl, provided that when X is CH, Z is N, R is NHNH 2 , R 1 is phenyl and R 2 is Cl, W and Y are not both CCH 3 ; one of R and R 2 is NR 3 R 4 and the other is halo, C 1-8 alkyl, C 1-8 alkoxy, C 1-8 alkylthio, C 2-8 alkenyl, C 2-8 alkynyl or cyano; R 1 is aryl, heteroaryl, morpholino, piperidino or pyrrolidino; R 3 and R 4 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, aryl(C 1-8 )-alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl, heteroaryl(C 1-8 )alkyl, NR 5 R 6 , provided that not v both R 3 and R 4 are H or NR 5 R 6 , or R 3 and R 4 together form a C 3-7 alkylene or C 3-7 alkenylene chain optionally substituted with one or more C 1-4 alkyl or C 1-4 alkoxy groups, or, together with the nitrogen atom to which they are attached, R 3 and R 4 form a morpholine, thiomorpholine, thiomorpholine S-oxide or thiomorpholine S-dioxide ring or a piperazine or piperazine N—(C 1-4 )alkyl (especially N-methyl) ring; and R 5 and R 6 are independently H, C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, aryl, aryl(C 1-8 )-alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl(C 1-6 )alkyl, heteroaryl or heteroaryl(C 1-8 )alkyl; any of the foregoing alkyl, alkenyl, alkynyl or cycloalkyl groups or moieties (other than for R 8 ) being optionally substituted with halogen, cyano, C 1-8 alkoxy C 1-4 alkylcarbonyl, C 1-6 alkoxycarbonyl, C 1-6 haloalkoxy, C 1-6 alkylthio, tri(C 1-4 )alkylsilyl, C 1-6 alkylamino or C 1-6 alkylamino, any of the foregoing morpholine, thiomorpholine, piperidine, piperazine and pyrrolidine rings being optionally substituted with C 1-4 alkyl (especially methyl), and any of the foregoing aryl or heteroaryl groups or moieties being optionally substituted with one or more substituents selected from halo, hydroxy, mercapto, C 1-4 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkenyloxy, C 2-6 alkynyloxy, halo(C 1-4 )alkyl, halo(C 1-6 )alkoxy, C 1-6 alkylthio, halo(C 1-4 )alkylthio, hydroxy(C 1-6 )alkyl, C 1-4 alkoxy(C 1-6 )alkyl, C 1-6 cycloalkyl, C 3-4 cycloalkyl(C 1-4 )alkyl, phenoxy, benzyloxy, benzoyloxy, cyano, isocyano, thiocyanato, isothiocyanato, nitro, —NHCOR″′, —NHCONR″′ R″″, —CONK″′R″″, SO 2 R″′, —OSO 2 R″′, —COR″′, —CR″′═NR″ or —N═CR″′R″″, in which R″′ and R″″ are independently hydrogen, C 1-4 alkyl, halo-(C 1-4 )alkyl, C 1-4 alkoxy, halo(C 1-4 )alkoxy, C 1-4 alkylthio, C 3-4 cycloalkyl, C 3-6 cycloalkyl(C 1-4 )alkyl, phenyl or benzyl groups beings optionally substituted with halogen, C 1-4 alkyl or C 1-4 alkoxy.

  广义式（1）的杀真菌组合物：其中W、X、Y和Z中的一个是N，其他为CR8; R8为H、卤素、C1-4烷基、C1-4烷氧基或卤代（C1-4）烷基，但当X为CH，Z为N，R为NHNH2，R1为苯基，R2为Cl，W和Y不都为CCH3时; R和R2中的一个是NR3R4，另一个是卤素、C1-8烷基、C1-8烷氧基、C1-8烷基硫基、C2-8烯基、C2-8炔基或氰基; R1为芳基、杂环芳基、吗啡基、哌啶基或吡咯啉基; R3和R4独立地为H、C1-8烷基、C2-8烯基、C2-8炔基、芳基、芳基（C1-8）-烷基、C3-8环烷基、C3-8环烷基（C1-6）-烷基、杂环芳基、杂环芳基（C1-8）-烷基、NR5R6，但不是R3和R4都是H或NR5R6，或者R3和R4一起形成一个C3-7烷基或C3-7烯基链，可选择地用一个或多个C1-4烷基或C1-4烷氧基取代，或者与它们所连接的氮原子一起，R3和R4形成吗啡啶、硫代吗啡啶、硫代吗啡啶S-氧化物或硫代吗啡啶S-二氧化物环或哌嗪或哌嗪N-（C1-4）烷基（尤其是N-甲基）环; R5和R6独立地为H、C1-8烷基、C2-8烯基、C2-8炔基、芳基、芳基（C1-8）-烷基、C3-8环烷基、C3-8环烷基（C1-6）-烷基、杂环芳基或杂环芳基（C1-8）-烷基; 除R8外，上述任何烷基、烯基、炔基或环烷基基团或基团均可选择地用卤素、氰基、C1-8烷氧基、C1-4烷基羰基、C1-6烷氧羰基、C1-6卤代烷氧基、C1-6烷基硫基、三（C1-4）烷基硅烷基、C1-6烷基氨基或C1-6烷基氨基取代; 上述任何吗啡啶、硫代吗啡啶、哌啶、哌嗪和吡咯啉环可选择地用C1-4烷基（尤其是甲基）取代; 上述任何芳基或杂环芳基基团或基团可选择地用一个或多个取代基取代，所述取代基由卤素、羟基、巯基、C1-4烷基、C2-6烯基、C2-6炔基、C1-6烷氧基、C2-6烯氧基、C2-6炔氧基、卤代（C1-4）烷基、卤代（C1-6）烷氧基、C1-6烷基硫基、卤代（C1-4）烷基硫基、羟基（C1-6）烷基、C1-4烷氧基（C1-6）烷基、C1-6环烷基、C3-4环烷基（C1-4）-烷基、苯氧基、苄氧基、苯甲酰氧基、氰基、异氰酸基、硫氰酸基、异硫氰酸基、硝基、—NHCOR″′、—NHCONR″′R″″、—CONK″′R″″、SO2R″′、—OSO2R″′、—COR″′、—CR″′═NR″或—N═CR″′R″″组成，其中R″′和R″″独立地为氢、C1-4烷基、卤代（C1-4）烷基、C1-4烷氧基、卤代（C1-4）烷氧基、C1-4烷基硫基、C3-4环烷基、C3-6环烷基（C1-4）-烷基、苯基或苄基，这些基团可选择地用卤素、C1-4烷基或C1-4烷氧基取代。