2,2,5,5-tetramethylpyrrolidinyl-1-oxy | 4567-19-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2,2,5,5-tetramethylpyrrolidinyl-1-oxy
• 英文别名: 2,2,5,5-tetramethyl-pyrrolidin-1-ol；1-Hydroxy-2,2,5,5-tetramethylpyrrolidine
• CAS: 4567-19-5
• 化学式: C₈H₁₇NO
• 分子量: 143.229
• InChiKey: FDFVVBKRHGRRFY-UHFFFAOYSA-N

物化性质

• 沸点：
  185.5±7.0 °C(Predicted)
• 密度：
  0.932±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2,2,5,5-tetramethylpyrrolidinyl-1-oxy 在 作用下， 生成 2,2,5,5-四甲基-1-吡咯烷基氧基
  参考文献：
  名称：

  Homosolvolysis

  摘要：

  DOI：

  10.1039/p29800000260
• 作为产物：
  描述：

  5-甲基-5-硝基己烷-2-酮 在 锌 作用下， 生成 2,2,5,5-tetramethylpyrrolidinyl-1-oxy
  参考文献：
  名称：

  Homosolvolysis

  摘要：

  DOI：

  10.1039/p29800000260

文献信息

• BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS
  申请人：International Business Machines Corporation

  公开号：US20160220705A1

  公开（公告）日：2016-08-04

  Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).

  具有顺磁性、两性亲疏性、生物相容性的聚合物已经制备好，其中包含一个带有顺磁性有机自由基的碳酸酯重复单元，更具体地说是一个亚硝基自由基。这种自由基聚合物可以通过将带有活性酯侧链的前体聚合物与带有自由基的亲核试剂处理而一步制备而成。前体聚合物可以通过有机催化的环氧化聚合（ROP）来制备，该环氧化单体带有活性酯侧链。这种自由基聚合物可能是无毒且部分可生物降解的。这种自由基聚合物在医学成像应用中可用作增强对比剂，和/或作为治疗医疗状况的治疗剂。这种自由基聚合物还可以作为治疗剂（例如药物）和/或医学图像增强剂（例如NIRF染料）的载体。
• [EN] NOVEL BIPHENYL SARTANS<br/>[FR] NOUVEAUX BIPHÉNYLSARTANS
  申请人：UNIV MELBOURNE

  公开号：WO2011134019A1

  公开（公告）日：2011-11-03

  The present invention relates to compounds and compositions useful in modulating the renin-angiotensin system (RAS) in cells, and in particular to compounds which, inter alia, act as angiotensin II antagonists by binding to angiotensin II receptors. The invention also relates to the use of these compounds and compositions in the treatment of conditions responsive to angiotensin II antagonists such as hypertension, edema, renal failure, benign prostatic hypertrophy glaucoma, atherosclerosis, diabetes, Alzheimer's disease and congestive heart failure.

  本发明涉及在细胞中调节肾素-血管紧张素系统（RAS）的化合物和组合物，特别是涉及一些作为血管紧张素II拮抗剂的化合物，通过结合血管紧张素II受体发挥作用。该发明还涉及在治疗对血管紧张素II拮抗剂敏感的疾病中使用这些化合物和组合物，如高血压、水肿、肾功能衰竭、良性前列腺增生、青光眼、动脉粥样硬化、糖尿病、阿尔茨海默病和充血性心力衰竭。
• [EN] METAL AMIDES OF CYCLIC AMINES<br/>[FR] AMIDES MÉTALLIQUES D'AMINES CYCLIQUES
  申请人：HARVARD COLLEGE

  公开号：WO2015013630A1

  公开（公告）日：2015-01-29

  Compounds, and oligomers of the compounds, are synthesized with cyclic amine ligands attached to a metal atom. These compounds are useful for the synthesis of materials containing metals. Examples include pure metals, metal alloys, metal oxides, metal nitrides, metal phosphides, metal sulfides, metal selenides, metal tellurides, metal borides, metal carbides, metal silicides and metal germanides. Techniques for materials synthesis include vapor deposition (chemical vapor deposition and atomic layer deposition), liquid solution methods (sol-gel and precipitation) and solid-state pyrolysis. Suitable applications include electrical interconnects in microelectronics and magnetoresistant layers in magnetic information storage devices. The films have very uniform thickness and high step coverage in narrow holes.

  含有环胺配体的化合物及其低聚物通过连接到金属原子进行合成。这些化合物对于合成含有金属的材料非常有用。例如包括纯金属、金属合金、金属氧化物、金属氮化物、金属磷化物、金属硫化物、金属硒化物、金属碲化物、金属硼化物、金属碳化物、金属硅化物和金属锗化物。材料合成技术包括气相沉积（化学气相沉积和原子层沉积）、液相溶液方法（溶胶-凝胶和沉淀）和固态热解。适用的应用领域包括微电子中的电气互连和磁性信息存储设备中的磁阻层。这些薄膜具有非常均匀的厚度，在狭窄的孔中具有高台阶覆盖率。
• Process for production of acrolein from glycerol
  申请人：Bogan, JR. Leonard Edward

  公开号：US20100168472A1

  公开（公告）日：2010-07-01

  The present invention relates to a process for producing acrolein by liquid phase dehydration of glycerol by preparing a mixture of a catalyst suspended in an organic solvent comprising one or more vinyl polymers and glycerol; and then mixing and heating the mixture to between 150° C. and 350° C. to dehydrate the glycerol and form acrolein. The vinyl polymers are selected from the group consisting of polyolefins, polystyrene, and mixtures thereof. The polyolefins may be polyethylene, polypropylene, polybutylene, polyisobutylene, polyisoprene, polypentene, or mixtures thereof. The acrolein may be subjected to vapor phase oxidation in the presence of a catalyst, such as a mixed metal oxide, to produce acrylic acid.

  本发明涉及一种通过制备悬浮在有机溶剂中的催化剂与甘油混合物，然后将混合物混合加热至150°C至350°C以脱水甘油并形成丙烯醛的液相脱水制备丙烯醛的方法。所述乙烯聚合物选自聚烯烃、聚苯乙烯及其混合物的群组。聚烯烃可以是聚乙烯、聚丙烯、聚丁烯、聚异丁烯、聚异戊二烯、聚戊烯或其混合物。丙烯醛可以在存在催化剂的情况下进行蒸汽相氧化，例如混合金属氧化物，以生产丙烯酸。
• Method for inhibiting polymerization of (meth)acrylic acid and its esters using an inhibitor and a process for making a compound useful as such an inhibitor
  申请人：Bass Stephen

  公开号：US20060074257A1

  公开（公告）日：2006-04-06

  This invention relates to a method for inhibiting polymerization of (meth)acrylic acid and its esters using a polymerization inhibitor which comprises at least one reduced halide-content azine dye-based compound. A process for producing reduced halide-content azine dye-based compounds using ion exchange resin technology is also provided.

  这项发明涉及一种使用至少一种含有还原卤化物的偶氮染料化合物作为聚合抑制剂来抑制（甲基）丙烯酸及其酯的聚合的方法。还提供了一种利用离子交换树脂技术生产含有还原卤化物的偶氮染料化合物的方法。