acetaldehyde N1-benzoyl-N1-(4-methoxyphenyl)hydrazone | 19155-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetaldehyde N1-benzoyl-N1-(4-methoxyphenyl)hydrazone
• 英文别名: Acetaldehyd-N-benzoyl-p-methoxy-phenylhydrazon；N'-ethylidene-N-(4-methoxyphenyl)benzohydrazide；N-(ethylideneamino)-N-(4-methoxyphenyl)benzamide
• CAS: 19155-13-6
• 化学式: C₁₆H₁₆N₂O₂
• 分子量: 268.315
• InChiKey: GUURWWRVORHFBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  acetaldehyde N1-benzoyl-N1-(4-methoxyphenyl)hydrazone 在 盐酸 作用下， 以 甲醇 、 溶剂黄146 、 甲苯 为溶剂， 反应 4.0h， 生成 2-(1-苯甲酰基-5-甲氧基-2-甲基吲哚-3-基)乙酸
  参考文献：
  名称：

  Synthesis of indomethacin analogues for evaluation as modulators of MRP activity

  摘要：

  Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(00)00292-3
• 作为产物：
  描述：

  (4-甲氧基苯基)肼 在 吡啶 作用下， 以 乙醚 为溶剂， 生成 acetaldehyde N1-benzoyl-N1-(4-methoxyphenyl)hydrazone
  参考文献：
  名称：

  Yamamoto,H. et al., Chemical and pharmaceutical bulletin, 1968, vol. 16, # 4, p. 647 - 653

  摘要：

  DOI：

文献信息

• Synthesis of COX-2 and FAAH inhibitors
  申请人：Bartolini Wilmin

  公开号：US20050234244A1

  公开（公告）日：2005-10-20

  Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

  描述了制备对COX-2抑制剂有用的吲哚和在这些方法中有用的中间体的方法。
• Indole derivatives useful to treat estrogen-related neoplasms and
  申请人：——

  公开号：US05877202A1

  公开（公告）日：1999-03-02

  The present invention relates to novel indole derivatives useful in down-regulating estrogen receptor expression. Also included are methods for the treatment of neoplasms or of controlling the growth of a neoplasm in a patient afflicted with a neoplastic disease, especially estrogen-dependent neoplasms such as those associated with breast, ovarian and cervical tissue. Another embodiment of the present invention is a method of prophylactically treating a patient at risk of developing a neoplastic disease state. Also provided is a method for treating autoimmune diseases. Also included are pharmaceutical compositions of the novel indole derivatives.

  本发明涉及新型吲哚衍生物，可用于下调雌激素受体表达。还包括用于治疗肿瘤或控制患有肿瘤性疾病的患者的肿瘤生长的方法，特别是雌激素依赖性肿瘤，如与乳腺、卵巢和宫颈组织相关的肿瘤。本发明的另一实施例是一种预防性治疗处于发展肿瘤性疾病状态的患者的方法。还提供了一种治疗自身免疫性疾病的方法。还包括新型吲哚衍生物的药物组合物。
• Selective Cox-2 Inhibitors
  申请人：Cali M. Brian

  公开号：US20070293542A1

  公开（公告）日：2007-12-20

  The invention features compounds that are inhibitors of COX-2 activity. Certain of the compounds are inhibitors of FAAH activity as well as COX-2 activity. The compounds include a 5-membered or 6-membered substituted or unsubstituted heteroaryl or heterocyclyl ring having one or two heteroatoms selected from the group consisting of O, S, and N that is linked to two substituted or unsubstituted 6-membered aryl or heteroaryl groups that can be the same or different.

  这项发明涉及一种抑制COX-2活性的化合物。其中一些化合物不仅是COX-2活性的抑制剂，还是FAAH活性的抑制剂。这些化合物包括一个带有一个或两个O、S或N杂原子的5元或6元取代或未取代的杂芳基或杂环基环，该环连接两个取代或未取代的6元芳基或杂芳基基团，这两个基团可以相同也可以不同。
• Methods and compositions for inhibiting or reducing hair loss, acne, rosacea, prostate cancer, and BPH
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10849841B2

  公开（公告）日：2020-12-01

  This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels.

  本发明提供了治疗雄激素性脱发(AGA)、痤疮、酒渣鼻、前列腺癌和良性前列腺肥大(BPH)的方法，包括使受试者与能降低前列腺素D2(PGD2)水平或活性、其下游信号传导或受体通路或前列腺素D2合成酶水平或活性的化合物或组合物接触的步骤；刺激毛发生长的方法，包括使受试者接触能提高或降低本发明靶基因活性或水平的化合物或组合物，或接触靶基因的蛋白产物或其类似物或模拟物；以及检测 AGA 和评估其治疗方法的方法，包括测量 PGD2 水平。
• NOVEL INDOLE DERIVATIVES USEFUL TO TREAT ESTROGEN-RELATED NEOPLASMS AND DISORDERS
  申请人：MERRELL PHARMACEUTICALS INC.

  公开号：EP0746544A1

  公开（公告）日：1996-12-11