2-溴-6-氯苯甲腈 | 6575-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-溴-6-氯苯甲腈
• 中文别名: 2-溴-6-氯苯腈
• 英文名称: 2-Bromo-6-chlorobenzonitrile
• CAS: 6575-08-2
• 化学式: C₇H₃BrClN
• 分子量: 216.46
• InChiKey: NVPXACXEVCJWCF-UHFFFAOYSA-N

物化性质

• 沸点：
  302.7±27.0 °C(Predicted)
• 密度：
  1.74±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2926909090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302+H312+H332,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  2-溴-6-氯苯甲腈 、 硫酸 以80%的产率得到
  参考文献：
  名称：

  TIMMERMANS P. B. M. W. M.; VAN ZWIETEN P. A.; SPECKAMP W. N., REC. TRAV. CHIM., 1978, 97, NO 2, 51-56

  摘要：

  DOI：

文献信息

• [EN] PEPTIDE MACROCYCLES AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] MACROCYCLES PEPTIDIQUES ET LEUR UTILISATION DANS LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2018189063A1

  公开（公告）日：2018-10-18

  The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8,R 8', R9, R9', X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.

  本发明提供了式（I）的化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R8'，R9，R9'，X1，X2，X3，X4，X5，X6，X7，X8，X9和X10如本文所述，以及其药学上可接受的盐。此外，本发明涉及式（I）化合物的制造，包含它们的制药组合物以及它们作为药物治疗Acinetobacter baumannii引起的疾病和感染的用途。
• Poly (arylene thioether) copolymer and preparation thereof
  申请人：Tosoh Corporation

  公开号：EP0337811A1

  公开（公告）日：1989-10-18

  Reaction of a dihalogenobenzonitrile and a dihalogenobenzene with a thioetherifying agent provides a poly(arylene thioether) copolymer which is both thermo­plastic and thermosetting in nature. Utilization of these dual properties results in products of improved physical properties.

  二卤代苯腈和二卤代苯与硫醚化剂发生反应，可产生一种具有热塑性和热固性的聚（芳基硫醚）共聚物。利用这些双重特性，可以生产出物理性能更好的产品。
• Poly(arylene thioether) copolymers and process for production thereof
  申请人：Tosoh Corporation

  公开号：EP0351136A2

  公开（公告）日：1990-01-17

  A novel class of poly(arylene) thioether) copolymers which are not only thermoplastic but thermosetting in nature. The copolymer may be prepared by copolymerizing a combination of dihalogenobenzonitrile, dihalogenobenzophenone and thioetherifying agent in an organic solvent. The copolymers are highly resistant to heat and solvents and exhibit excellent mechanical properties at raised temperatures.

  一种新型聚（芳烯烃）硫醚共聚物，不仅具有热塑性，还具有热固性。这种共聚物可通过在有机溶剂中共聚二卤代苯腈、二卤代二苯甲酮和硫醚化剂的组合来制备。 这种共聚物具有很强的耐热性和耐溶剂性，在高温下具有优异的机械性能。
• PEPTIDE MACROCYCLES AND USE THEREOF IN THE TREATMENT OF BACTERIAL INFECTIONS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3388445A1

  公开（公告）日：2018-10-17

  The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R8', R9, R9', X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.

  本发明提供了式 (I) 的化合物 其中 R1、R2、R3、R4、R5、R6、R7、R8、R8'、R9、R9'、X1、X2、X3、X4、X5、X6、X7、X8、X9 和 X10 如本文所述，以及其药学上可接受的盐。此外，本发明还涉及式（I）化合物的制造、包含它们的药物组合物以及它们作为治疗鲍曼不动杆菌引起的疾病和感染的药物的用途。
• Peptide macrocycles and use thereof in the treatment of bacterial infections
  申请人：Hoffmann-La Roche Inc.

  公开号：US11091514B2

  公开（公告）日：2021-08-17

  The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R8′, R9, R9′, X1, X2, X3, X4, X5, X6, X7, X8, X9 and X10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baurnannii.

  本发明提供了式 (I) 的化合物 其中R1、R2、R3、R4、R5、R6、R7、R8、R8′、R9、R9′、X1、X2、X3、X4、X5、X6、X7、X8、X9和X10如本文所述，以及它们的药学上可接受的盐。此外，本发明还涉及式(Ⅰ)化合物的制造、包含它们的药物组合物以及它们作为治疗鲍曼不动杆菌引起的疾病和感染的药物的用途。