methyl 4'-(N,N-dimethylanilino)pyridinium iodide hydrate | 1141-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: methyl 4'-(N,N-dimethylanilino)pyridinium iodide hydrate
• 英文别名: 1-methyl-4-<4-(N,N-dimethylamino)phenyl>pyridinium iodide；1-methyl-4-(4'-dimethylaminophenyl)pyridinium iodide；4-(4-(dimethylamino)phenyl)-1-methylpyridinium iodide；4-(p-N,N-Dimethylaminophenyl)pyridinmethiodid；4-(4-(Dimethylamino)phenyl)-1-methylpyridin-1-ium iodide；N,N-dimethyl-4-(1-methylpyridin-1-ium-4-yl)aniline;iodide
• CAS: 1141-41-9
• 化学式: C₁₄H₁₇N₂*I
• 分子量: 340.207
• InChiKey: CAMWVBRDIKKGII-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.75
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 4'-(N,N-dimethylanilino)pyridinium iodide hydrate 、 tetrabutylammonium 4"-nitro-p-terphenylmalononitrile 以 甲醇 、 水 为溶剂， 以47%的产率得到methyl 4-(N,N-dimethylanilinopyridinium) 4"-nitro-p-terphenylmalononitrile
  参考文献：
  名称：

  Synthesis of Dicyanomethyl and Nitro Substituted p-Polyphenyls and Their Salts

  摘要：

  由 4,4'- 或 4''-二碘对位多苯基和 4-碘-4'- 或 4''-硝基一步、中等规模合成几种新型二氰基甲基和硝基取代的对多苯基分别报道了使用钯催化剂的对聚苯和丙二腈钠。同样描述了这些扩展π电子系统的许多有机阳离子盐。

  DOI：

  10.1055/s-1995-3984
• 作为产物：
  描述：

  N,N-二甲基-4-(4-吡啶基)苯胺 、 碘甲烷 以 乙腈 为溶剂， 反应 4.0h， 生成 methyl 4'-(N,N-dimethylanilino)pyridinium iodide hydrate
  参考文献：
  名称：

  FLUORESCENT SUBSTRATES FOR NEUROTRANSMITTER TRANSPORTERS

  摘要：

  该发明基于发现，IDT307及其类似物是多种神经递质转运体传输的荧光底物。提供了使用IDT307及其类似物进行神经递质转运和结合分析的方法。该发明还提供了筛选神经递质转运调节剂的快速方法。

  公开号：

  US20080108102A1

文献信息

• FLUORESCENT SUBSTRATES FOR NEUROTRANSMITTER TRANSPORTERS
  申请人：Blakely D. Randy

  公开号：US20080108102A1

  公开（公告）日：2008-05-08

  The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport.

  该发明基于发现，IDT307及其类似物是多种神经递质转运体传输的荧光底物。提供了使用IDT307及其类似物进行神经递质转运和结合分析的方法。该发明还提供了筛选神经递质转运调节剂的快速方法。
• Fluorescent Substrates for Neurotransmitter Transporters
  申请人：Blakely Randy D.

  公开号：US20110229910A1

  公开（公告）日：2011-09-22

  The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport.

  本发明基于发现 IDT307 及其类似物是多种神经递质转运体运输的荧光底物。提供了使用 IDT307 及其类似物分析神经递质转运和结合的方法。本发明还提供了筛选神经递质转运调节剂的快速方法。
• Fluorescent substrates for neurotransmitter transporters
  申请人：Vanderbilt University

  公开号：US07947255B2

  公开（公告）日：2011-05-24

  The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The invention also provides rapid methods for screening for modulators of neurotransmitter transport.

  该发明基于发现，IDT307及其类似物是多种神经递质转运体转运的荧光底物。提供了使用IDT307及其类似物进行神经递质转运和结合分析的方法。该发明还提供了用于筛选神经递质转运调节剂的快速方法。
• Neurotransmitter transport in probiotics
  申请人：IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

  公开号：US10941433B2

  公开（公告）日：2021-03-09

  The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders.

  本发明涉及基于微生物生物胺吸收能力的益生菌选择和使用方法，作为一种有针对性的临床和兽医应用方法，包括促进健康和福祉和/或治疗条件。本发明利用一种以微生物为重点的方法来开发各种疾病和失调的药物选择和/或益生菌给药。
• Norepinepherine Transporter Mutants and Uses Thereof
  申请人：Blakely Randy D.

  公开号：US20090156530A1

  公开（公告）日：2009-06-18

  The present invention provides norepinepherine transporter (NET) mutants which display altered phosphorylation at site T30 and altered receptor trafficking. Methods for the use of the NET mutants, e.g., screening of compounds which alter NET trafficking, are also provided. A transgenic animal such as a mouse may comprise a NET mutant of the present invention.