2-溴-N-丙基苯磺酰胺 | 951883-92-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-溴-N-丙基苯磺酰胺
• 英文名称: 2-bromo-N-propylbenzenesulfonamide
• CAS: 951883-92-4
• 化学式: C₉H₁₂BrNO₂S
• mdl: MFCD09800953
• 分子量: 278.17
• InChiKey: PYFAHNNJLVPABD-UHFFFAOYSA-N

物化性质

• 沸点：
  365.1±44.0 °C(Predicted)
• 密度：
  1.470±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2935009090

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
2-Bromo-N-propylbenzenesulfonamide
Product Name:
Synonyms: N-Propyl 2-bromobenzenesulfonamide

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present
and easy to do – continue rinsing
P302+P352: IF ON SKIN: Wash with soap and water
P321: Specific treatment (see on this label)
P405: Store locked up

---

Section 3. Composition/information on ingredients.
2-Bromo-N-propylbenzenesulfonamide
Ingredient name:
CAS number: 951883-92-4

---

Section 4. First aid measures
Immediately wash skin with copious amounts of water for at least 15 minutes while removing
Skin contact:
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Ingestion:

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C9H12BrNO2S
Molecular weight: 278.2

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen bromide, sulfur oxides.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2-溴-N-丙基苯磺酰胺 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 2-ethynyl-N-propylbenzenesulfonamide
  参考文献：
  名称：

  通过布朗斯台德酸催化非对映选择性合成1,3-二取代的异吲哚啉和sultams。

  摘要：

  报道了双（三氟甲烷）磺酰亚胺（Tf2NH）催化末端炔烃的分子内加氢酰胺化。Et3SiH和Tf2NH的组合以高收率（最高98％）和高非对映选择性（最高99：1 dr）提供了顺式1,3-二取代的异吲哚啉和sultams。

  DOI：

  10.1039/c8cc04946g
• 作为产物：
  描述：

  正丙胺 、 2-溴苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-溴-N-丙基苯磺酰胺
  参考文献：
  名称：

  可见光诱导的双自由基介导的 ipso 环化朝向双脱芳烃 [2+2]-环加成或微笑型重排

  摘要：

  双自由基介导的 ipso环化涉及将芳香族化合物的螺环中间体脱芳构化到不同的反应途径值得研究，但迄今为止很少有报道。通过调节关键的脱芳构化螺环中间体中 C-S 键的断裂速率，在涉及双自由基物种的可见光诱导能量转移反应途径中实现了（杂）芳基磺酰胺的化学发散反应。

  DOI：

  10.1002/chem.202203217

文献信息

• Palladium-catalysed direct heteroarylation of bromobenzenes bearing SO2R substituents at C2 or C4
  作者：Charles Beromeo Bheeter、Rongwei Jin、Jitendra K. Bera、Henri Doucet

  DOI：10.1039/c3ra40769a

  日期：——

  Palladium-catalysed direct arylation of 4- or 2-bromobenzenesulfonic acid derivatives in the presence of a variety of heteroaromatics was found to proceed using 0.1–0.5 mol% palladium acetate as the catalyst. However, both the nature and position of the SO2R substituent on such bromobenzenes has an influence on the reaction rates and yields. The presence of SO2Et or SO2NEt2 at the C2 or C4 position of bromobenzene is tolerated. Good results were also obtained from bromobenzene substituted at C4 by SO2NHPh or SO2OPh. On the other hand, the reactions of bromobenzenes bearing either SO2N(Me)CH2Ph or SO2OAr at C2 led in some cases to intramolecular reactions instead of the desired intermolecular couplings. Some reactions were performed in cyclopentyl methyl ether, which can be considered as a green solvent.

  使用0.1-0.5%摩尔的醋酸钯作为催化剂，在多种杂芳环存在下，发现钯催化的4-或2-溴苯磺酸衍生物的直接芳基化反应可以进行。然而，溴苯上SO2R取代基的性质和位置对反应速率和产率有影响。在溴苯的C2或C4位置存在SO2Et或SO2NEt2是可以容忍的。在C4位置由SO2NHPh或SO2OPh取代的溴苯也得到了良好的结果。另一方面，在C2位置带有SO2N(Me)CH2Ph或SO2OAr的溴苯的反应在某些情况下会导致分子内反应，而不是所期望的分子间偶联。一些反应在环戊基甲基醚中进行，这种溶剂可以被认为是一种环保溶剂。
• Palladium-Catalyzed CC Coupling of Aryl Halides with Isocyanides: An Alternative Method for the Stereoselective Synthesis of (3E)-(Imino)isoindolin-1-ones and (3E)-(Imino)thiaisoindoline 1,1-Dioxides
  作者：Bifu Liu、Yibiao Li、Huanfeng Jiang、Meizhou Yin、Huawen Huang

  DOI：10.1002/adsc.201200212

  日期：2012.8.13

  transformation successfully extends its application for the synthesis of phenanthridines and dibenzooxazepines. This new synthetic protocol not only extends the application platform for palladium-catalyzed CC coupling of aryl halides with isocyanides, but also opens atom-economic and step-economic synthetic routes for nitrogen-containing heterocyclic compounds with wide functional group compatibility.

  钯催化的一锅环化反应，通过引入邻位结构来构建（3 E）-（亚氨基）异吲哚啉-1-酮和（3 E）-（亚氨基）硫代异吲哚啉1,1-二氧化物报道了芳基卤上的-反应性官能团。在最佳条件下，环化反应可提供具有良好立体选择性的高至优收率（最高93％）的相应产物。值得注意的是，这种转化成功地扩展了其在菲啶和二苯并恶氮ze合成中的应用。这一新的合成方案不仅扩展了芳基卤化物与异氰化物的钯催化CC偶联的应用平台，而且为具有广泛官能团相容性的含氮杂环化合物开辟了原子经济和分步经济的合成途径。
• An electrochemical γ-C–H arylation of amines in continuous flow
  作者：José A. Forni、Milena L. Czyz、David W. Lupton、Anastasios Polyzos

  DOI：10.1016/j.tetlet.2022.153647

  日期：2022.2

  C(sp3)–C(sp2) cross coupling reaction between inert γ-C(sp3)–H bonds in aliphatic amines and cyanoarenes under electrochemical conditions in flow. The developed methodology takes advantage of a removable redox active auxiliary, which triggers selective 1,7-hydrogen atom transfer to functionalise an aliphatic C–H bond at the γ-position of an alkyl amine. In this reaction, a cyanoarene radical anion functions as

  本文报道了在流动的电化学条件下，脂肪胺和氰基芳烃中惰性 γ-C(sp 3 )-H 键之间的区域选择性 C(sp 3 )–C(sp 2 ) 交叉偶联反应。所开发的方法利用可去除的氧化还原活性助剂，它触发选择性的 1,7-氢原子转移，以使烷基胺 γ 位上的脂肪族 C-H 键功能化。在该反应中，氰基芳基阴离子既可作为选择性芳基化试剂又可作为氧化还原活性介体，使氧化还原活性助剂的一个电子还原成为可控的。该策略为 γ-C(sp 3)–H 键功能化允许在温和的反应条件和不存在额外催化剂或自由基引发剂的情况下产生空间拥挤的碳中心等。
• FLAP MODULATORS
  申请人：Janssen Pharmaceutica NV

  公开号：EP3495359A1

  公开（公告）日：2019-06-12

  The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R1, R2, R3, R3', L, W, and V are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.

  本发明涉及式（I）化合物、 或其形式，其中环 A、R1、R2、R3、R3'、L、W 和 V 如本文所定义，可用作 FLAP 调节剂。本发明还涉及包含式（I）化合物的药物组合物。式（I）化合物的制造和使用方法也属于本发明的范围。
• Diastereoselective synthesis of 1,3-disubstituted isoindolines and sultams <i>via</i> bronsted acid catalysis
  作者：Ye Tao、Scott R. Gilbertson

  DOI：10.1039/c8cc04946g

  日期：——

  The bis(trifluoromethane)sulfonimide (Tf2NH) catalyzed intramolecular hydroamidation of terminal alkynes is reported. The combination of Et3SiH and Tf2NH provides cis-1,3-disubstituted isoindolines and sultams in high yield (up to 98%) and high diastereoselectivity (up to 99 : 1 d.r.).

  报道了双（三氟甲烷）磺酰亚胺（Tf2NH）催化末端炔烃的分子内加氢酰胺化。Et3SiH和Tf2NH的组合以高收率（最高98％）和高非对映选择性（最高99：1 dr）提供了顺式1,3-二取代的异吲哚啉和sultams。