Triamcinolone diacetate | 67-78-7

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Triamcinolone diacetate
• 英文别名: Triamcinolon-diacetat；[2-[(9R,10S,11S,13S,16R,17S)-16-acetyloxy-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
• CAS: 67-78-7；4001-36-9
• 化学式: C₂₅H₃₁FO₈
• 分子量: 478.515
• InChiKey: XGMPVBXKDAHORN-KUZKEXDLSA-N

物化性质

• 熔点：
  186-188 C
• 比旋光度：
  D25 +22° (chloroform)
• 沸点：
  608.5±55.0 °C(Predicted)
• 密度：
  1.2087 (estimate)
• 溶解度：
  可溶于氯仿（轻微、加热）、DMSO（轻微）、甲醇（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  9

安全信息

• WGK Germany：
  3
• 海关编码：
  29349990
• 危险类别：
  3
• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R10
• 包装等级：
  III
• 危险品运输编号：
  UN 3272 3/PG 3

SDS

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Section 1. Chemical Product and Company Identification
Triamcinolone diacetate
Common Name/
Trade Name
Triamcinolone diacetate

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Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
Products of Combustion These products are carbon oxides (CO, CO2), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
Risks of explosion of the product in presence of static discharge: Not available.
of Various Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
As with most organic solids, fire is possible at elevated temperatures.
Special Remarks on
When heated to decomposition it emits acrid smoke and toxic fumes of Fluorine.
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust
Hazards explosion hazard.

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Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Triamcinolone diacetate

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Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
breathe dust.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.

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Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection
Safety glasses. Lab coat. Dust respirator. Use a dust respirator if ventilation is inadequate and is handling of
material creates visible dust clouds. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powdered solid. Crystalline powder.) Odor Slight.
Taste Not available.
Molecular Weight 478.51 g/mole
Color White. Off-white.
pH (1% soln/water) Not applicable.
Boiling Point Not available.
Melting Point 186°C (366.8°F) - 188 C.
Critical Temperature Not available.
Not available.
Specific Gravity
Vapor Pressure Not applicable.
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water) Not available.
Not available.
Dispersion Properties
Solubility Insoluble in cold water, hot water.

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Section 10. Stability and Reactivity Data
Stability The product is stable.
Not available.
Instability Temperature
Conditions of Instability Excess heat
Incompatibility with various Not available.
substances
Corrosivity Non-corrosive in presence of glass.
Triamcinolone diacetate
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.

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Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on
May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data
Chronic Effects on Humans
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation with itching, erythema, folliculitis, pustules, pyoderma, vesiculation, hyperesthesia.
Eyes: Dust may cause eye irritation.
Inhalation: Dust may cause respiratory tract irritation.
Ingestion: May cause gastrointestinal tract irritation with indigestion. Ingestion as well as if orally-inhaled may
cause adverse effects which may include decreased or blurred vision, frequent urination, increased thirst, loss or
increase of appetite, nervousness or restlessness, and trouble sleeping, hypertension, electrolyte imbalances due
to sodiuim/fluid retention, hyperglycemia and glycosuria.
Note: Possible allergic reaction to material if inhaled, ingested or in contact with skin.
Chronic Potential Health Effects: Possible hypersensitization, acne or other skin problems, hip or shoulder pain,
fullness in face, swelling of feet or lower legs, menstrual irregularities, hirsutism, hypopigmentation, nausea,
vomiting, irregular heartbeat, muscle cramps, weakness, osteoporisis, increased susceptibilitiy to infection,
psychosis, and eye problems (cataracts, glaucoma with possible damage to the optic nerve).
Prolonged or repeated skin contact may cause itching, allergic contact dermatitis.
Medical Conditons Aggravated by Exposure: Hypersensitivity to this material or other corticosteroids; ocular
herpes simples; active alcoholism; AIDS or HIV infection; heart disease or hypertension; diabetes mellitus;
myasthenia gravis; impaired liver or kidney function; esophagitis; gastritis or peptic ulcer; chickenpox or measles
(including recent exposure); tuberculosis; and system fungal infections.

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Section 12. Ecological Information
Not available.
Ecotoxicity
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are more toxic than the product itself.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation
Triamcinolone diacetate

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Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California California prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
Other Classifications WHMIS (Canada) Not controlled under WHMIS (Canada).
DSCL (EEC) This product is not classified according Not applicable.
to the EU regulations.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Triamcinolone diacetate
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

类别：有毒物品

可燃性危险特性：

• 可燃
• 燃烧时产生有毒氟化物烟雾

储运特性：

• 库房应通风、低温且干燥

灭火剂：

• 干粉
• 泡沫
• 沙土
• 二氧化碳
• 雾状水