2,3-Dihydro-1H-benzimidazol-2-amine | 98678-91-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,3-Dihydro-1H-benzimidazol-2-amine
• CAS: 98678-91-2
• 化学式: C₇H₉N₃
• 分子量: 135.17
• InChiKey: VRLMGRFXXRWBOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• METHODS AND COMPOSITIONS FOR TREATING CARDIAC DYSFUNCTIONS
  申请人：Mackman Nigel

  公开号：US20090022729A1

  公开（公告）日：2009-01-22

  The present invention provides methods and pharmaceutical compositions for treating or preventing cardiac dysfunctions (e.g., cardiac hypertrophy, cardiac remodeling, or heart failure) in subjects who have or are likely to develop cardiomyopathies. Some of the methods are directed to therapeutic or prophylactic treatment of cardiac dysfunctions in subjects having undergone myocardial injuries such as cardiac ischemia/reperfusion or myocardial infarction. Typically, these methods comprising administering to the subjects a therapeutic composition comprising a compound which can specifically inhibit PAR1 mediated signaling or down-regulate the cellular level of PAR1.