4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]thieno[3,2-d]pyrimidine | 295776-70-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]thieno[3,2-d]pyrimidine
• 英文别名: N-[4-methyl-3-(thieno[3,2-d]pyrimidin-4-ylamino)phenyl]-2-morpholin-4-ylpyridine-4-carboxamide
• CAS: 295776-70-4
• 化学式: C₂₃H₂₂N₆O₂S
• 分子量: 446.533
• InChiKey: DKRNQKDMLWIACW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  121
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-氯噻吩并[3,2-d]嘧啶 、 N,N-二甲基甲酰胺 、 N-(3-amino-4-methylphenyl)-2-morpholinopyridine-4-carboxamide 在 三乙胺 作用下， 生成 4-[2-methyl-5-(2-morpholinopyridine-4-carboxamido)anilino]thieno[3,2-d]pyrimidine
  参考文献：
  名称：

  PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE

  摘要：

  公开号：

  EP1165566B1

文献信息

• US6784174B1
  申请人：——

  公开号：US6784174B1

  公开（公告）日：2004-08-31
• [EN] PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE<br/>[FR] DERIVES DE PYRIDINE ET DE PYRIMIDINE ET LEUR UTILISATION COMME INHIBITEURS DE MALADIES ASSOCIEES A LA CYTOKINE
  申请人：ASTRAZENECA AB

  公开号：WO2000056738A1

  公开（公告）日：2000-09-28

  This invention concerns a bicyclic compound of Formula (I), wherein: G is N, CH or C(CN); ring X is a 5- or 6-membered fused heteroaryl ring which contains 1, 2, or 3 heteroatoms selected from oxygen, sulphur and nitrogen; m is 0 - 2; R1 is a group such as hydroxy, halo, trifluoromethyl, cyano, mercapto, nitro, amino, carboxy and carbamoyl; each of R?2 and R3¿ is hydrogen, halo, C¿1-6?alkyl, C2-6alkenyl or C2-6alkynyl; R?4¿ is a group such as hydrogen, hydroxy, C¿1-6?alkyl, C1-6alkoxy, amino and N-C1-6alkylamino; R?5¿ is a group such as hydrogen, halo, trifluoromethyl, cyano, nitro, amino and hydroxy, and q is 0 - 4; or a pharmaceutically acceptable salt or an in vivo cleavable ester thereof; processes for its preparation, a pharmaceutical composition containing it and its use in the treatment of diseases or medical conditions mediated by cytokines.
• PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF CYTOKINE MEDIATED DISEASE
  申请人：AstraZeneca AB

  公开号：EP1165566B1

  公开（公告）日：2003-08-20