1-hydroxy-4-(β-D-galactopyranosyloxy)-9,10-anthracenedione | 1094624-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1-hydroxy-4-(β-D-galactopyranosyloxy)-9,10-anthracenedione
• 英文别名: 1-hydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyanthracene-9,10-dione
• CAS: 1094624-15-3
• 化学式: C₂₀H₁₈O₉
• 分子量: 402.358
• InChiKey: QOFONQRSLUINFK-OHNCIUIWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  1-hydroxy-4-[(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)oxy]-9,10-anthracenedione 在 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以96.8%的产率得到1-hydroxy-4-(β-D-galactopyranosyloxy)-9,10-anthracenedione
  参考文献：
  名称：

  Chemical Synthesis and In Vitro Antitumor Activity of Quinizarin Glycoside Analogs

  摘要：

  A series of new glycoside derivatives of quinizarin were synthesized and characterized by NMR and IR spectrometry, and in vitro antitumor activity of some of these derivatives was evaluated against the mouse leukaemia P388 and the human leukaemia HL-60 cell lines by the standard MTT assay. They were proven to possess moderate antitumor activity.

  DOI：

  10.1080/00397910802279852

文献信息

• Chemical Synthesis and In Vitro Antitumor Activity of Quinizarin Glycoside Analogs
  作者：Xiaofei Sun、Li Ji、Sumei Ren、Shengbiao Wan、Tao Jiang

  DOI：10.1080/00397910802279852

  日期：2008.11.3

  A series of new glycoside derivatives of quinizarin were synthesized and characterized by NMR and IR spectrometry, and in vitro antitumor activity of some of these derivatives was evaluated against the mouse leukaemia P388 and the human leukaemia HL-60 cell lines by the standard MTT assay. They were proven to possess moderate antitumor activity.