2-甲基-1-苯基-1-丁胺 | 56640-53-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲基-1-苯基-1-丁胺
• 英文名称: 2-methyl-1-phenyl-butylamine
• 英文别名: 1-Phenyl-2-methyl-n-butylamin；2-Methyl-1-phenylbutan-1-amine
• CAS: 56640-53-0
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: PCELVXFUVRHMRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-甲基-1-苯基-1-丁胺 生成 甲基-(2-甲基-1-苯基-丁基)-胺
  参考文献：
  名称：

  DE1008305

  摘要：

  公开号：
• 作为产物：
  描述：

  2-methylbutyrophenone oxime 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-甲基-1-苯基-1-丁胺
  参考文献：
  名称：

  系统中的立体效果

  摘要：

  基团R的增加导致在Ph·CH（NH 2）·R类型的胺的甲基化中形成较高比例的酮，并在乙氧基的肟的铝氢化物还原中形成较高比例的仲胺。类型Ph·C（：NOH）·R。

  DOI：

  10.1016/s0040-4020(01)96946-7

文献信息

• PROCESS FOR PRODUCING 1-SUBSTITUTED TRANS-4-(SUBSTITUTED AMINO) PIPERIDIN-3-OL
  申请人：Aikawa Toshiaki

  公开号：US20110172431A1

  公开（公告）日：2011-07-14

  A process is provided for producing a 1-substituted trans-4-(substituted amino)piperidin-3-ol represented by formula (III-1): The process includes a step of reacting a 1-substituted-3,4-epoxypiperidine represented by formula (I): with an amine compound represented by formula (II) in the presence of an inorganic lithium salt. By utilizing the process, trans-4-aminopiperidin-3-ol compounds useful as various chemical products, such as medicine intermediates, can be produced.

  提供了一种生产1-取代的反式-4-(取代氨基)哌啶-3-醇的过程，其化学式为(III-1)：该过程包括以下步骤：将一种化学式为(I)的1-取代-3,4-环氧哌啶与一种化学式为(II)的胺化合物在无机锂盐存在下反应。通过利用该过程，可以生产用途广泛的反式-4-氨基哌啶-3-醇化合物，如药物中间体等化学产品。
• Synthesis of secondary carbinamine via n-boryl imines generated from nitriles and alkylboranes
  作者：Shinichi Itsuno、Chiharu Hachisuka、Keisuke Kitano、Koichi Ito

  DOI：10.1016/s0040-4039(00)92328-1

  日期：1992.1

  The partial reduction of nitriles with several alkylboranes produced an addition product, N-boryl imine, which was readily converted to secondary carbinamine by treatment with organolithium or Grignard reagents. Optically active N-boryl imines were also prepared from chiral borane and nitrile for the chiral amine synthesis.

  用几种烷基硼烷部分还原腈可生成加成产物N-硼基亚胺，可通过用有机锂或格利雅试剂处理将其轻松转化为仲甲胺。还从手性硼烷和腈制备光学活性的N-硼亚胺，用于手性胺的合成。
• PROCESS FOR PRODUCING 1-SUBSTITUTED TRANS-4-(SUBSTITUTED AMINO)PIPERIDIN-3-OL
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP2351738A1

  公开（公告）日：2011-08-03

  A process for producing a 1-substituted trans-4-(substituted amino)piperidin-3-ol represented by formula (III-1): wherein R1 represents an aromatic carbocyclic group, an alkyl group having 1 to 12 carbon atoms which may be substituted with one or more aromatic carbocyclic groups, an alkenyl group having 2 to 14 carbon atoms which may be substituted with one or more aromatic carbocyclic groups, or an alkynyl group having 2 to 12 carbon atoms which may be substituted with one or more aromatic carbocyclic groups, and the like, which comprises a step of reacting a 1-substituted-3,4-epoxypiperidine represented by formula (I): with an amine compound represented by formula (II) in the presence of an inorganic lithium salt. By utilizing the process, trans-4-aminopiperidin-3-ol compounds useful as various chemical products, such as medicine intermediates, can be produced.

  一种生产式 (III-1) 所代表的 1-取代反式-4-(取代氨基)哌啶-3-醇的工艺： 其中 R1 代表芳香族碳环基团、具有 1 至 12 个碳原子且可被一个或多个芳香族碳环基团取代的烷基、具有 2 至 14 个碳原子且可被一个或多个芳香族碳环基团取代的烯基、或具有 2 至 12 个碳原子且可被一个或多个芳香族碳环基团取代的炔基等、 其中包括使式（I）代表的 1-取代-3,4-环氧哌啶反应的步骤： 与式 (II) 所代表的胺化合物反应 在无机锂盐存在下进行。利用该工艺可生产出反式-4-氨基哌啶-3-醇化合物，该化合物可用作各种化学产品，如医药中间体。
• Carbon–carbon bond formations at the benzylic positions of N-benzylxanthone imines and N-benzyldi-1-naphthyl ketone imine
  作者：Takashi Niwa、Takafumi Suehiro、Hideki Yorimitsu、Koichiro Oshima

  DOI：10.1016/j.tet.2009.02.034

  日期：2009.6

  Two N-benzyl imines are designed to allow for carbon-carbon bond formations at the aminated benzylic positions. Direct benzylic arylation reactions of N-benzylxanthone imine with aryl chlorides proceed under palladium catalysis in the presence of cesium hydroxide, yielding the corresponding benzhydrylamine derivatives. Alkylation reactions of N-benzyldi-1-naphthyl ketone imine with alkyl halides in the presence of potassium tert-butoxide afford the corresponding 1-phenylalkylamines in high yields. Conjugate addition of N-benzyldi-1-naphthyl ketone imine is also described. (C) 2009 Elsevier Ltd. All rights reserved.
• Parallel synthesis and evaluation of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines as Na+/K+ ATPase inhibitors
  作者：Benjamin E. Blass、C.T. Huang、Richard M. Kawamoto、Min Li、Song Liu、David E. Portlock、William M. Rennells、Melanie Simmons

  DOI：10.1016/s0960-894x(00)00296-1

  日期：2000.7

  A series of N-(1-phenylethyl)-5-phenyl-imidazole-2-amines was prepared using solution-phase, parallel synthesis and evaluated for Na+/K+ ATPase inhibition. (C) 2000 Elsevier Science Ltd. All rights reserved.