9-Methyl-S-triazolo<4,3-a>benzimidazol-3-thion | 2165-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 9-Methyl-S-triazolo<4,3-a>benzimidazol-3-thion
• 英文别名: 9-methyl-9H-[1,2,4]triazolo[4,3-a]benzimidazole-3-thiol；4-methyl-2H-[1,2,4]triazolo[4,3-a]benzimidazole-1-thione
• CAS: 2165-12-0
• 化学式: C₉H₈N₄S
• mdl: MFCD03767537
• 分子量: 204.255
• InChiKey: KKRXWMLLDAIWCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  63
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  吗啉 、 聚合甲醛 、 9-Methyl-S-triazolo<4,3-a>benzimidazol-3-thion 生成 9-methyl-2-morpholin-4-ylmethyl-2,9-dihydro-benzo[4,5]imidazo[2,1-c][1,2,4]triazole-3-thione
  参考文献：
  名称：

  Bednyagina,N.P.; Getsova,I.N., Journal of Organic Chemistry USSR (English Translation), 1965, vol. 1, p. 135 - 137

  摘要：

  DOI：
• 作为产物：
  描述：

  N-Phenyl-2-(1-methylbenzimidazol-2-yl)hydrazinocarbothioamide 生成 9-Methyl-S-triazolo<4,3-a>benzimidazol-3-thion
  参考文献：
  名称：

  N-取代-2-苯并唑-2-基肼基碳硫酰胺的合成及其抗流感活性

  摘要：

  NS Egorov，抗生素科学基础 [俄文]，第 3 版，莫斯科（1979 年），第 46-47 页~ VI ll'enko，化合物抗流感病毒抗病毒活性的测试和评估方法。方法论[俄语]，列宁格勒（1977 年）。GA Mokrushina、SK Kotovskaya 和 GA Yurchenko，有机硫化合物和含硫石油化学与技术会议。第 16 号：论文摘要 [俄文]，里加，1984 年，第 1 页。187. GA Mokrushina、SK Kotovskaya、GN Tyurenkova 等人，Khim.-farm。Zh., No. 2, 195 (1988).

  DOI：

  10.1007/bf00758277

文献信息

• TYURENKOVA, G. N.;ILENKO, V. I.;SEREBRYAKOVA, N. V.;PLATONOV, V. G.;MOKRU+, XIM.-FARMATS. ZH., 22,(1988) N 3, 320-323
  作者：TYURENKOVA, G. N.、ILENKO, V. I.、SEREBRYAKOVA, N. V.、PLATONOV, V. G.、MOKRU+

  DOI：——

  日期：——
• TYROSINASE INHIBITORS
  申请人：Avon Products, Inc.

  公开号：US20150152122A1

  公开（公告）日：2015-06-04

  The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.
• [EN] TYROSINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINASE
  申请人：AVON PROD INC

  公开号：WO2014158943A1

  公开（公告）日：2014-10-02

  The compositions and methods of described herein comprise novel ingredients effective to reduce unwanted pigmentation, such as skin discoloration, freckles, age spots, liver spots, sun damage, tans, pigmented acne marks, scars, pigmented birthmarks, hyperpigmentation, post-inflammatory hyperpigmentation, post-injury hyperpigmentation, melasma, cholasma, after-burn scar, nail stain, yellowing of skin, dark circles under eyes, and the like. The composition may include additional ingredients accordingly for a colored cosmetic, moisturizer, cleanser, toner, and the like.
• Synthesis and anti-influenzaactivity of N-substituted-2-benzazol-2-ylhydrazinocarbothioamides
  作者：G. N. Tyurenkova、V. I. Il'enko、N. V. Serebryakova、V. G. Platonov、G. A. Mokrushina、I. I. Mudretsova

  DOI：10.1007/bf00758277

  日期：1988.3

  Scientific Fundamentals of Antibiotics [in Russian], 3rd edition, Moscow (1979), pp. 46-47~ V. I. ll'enko, Methods of Testing and Assessment of the Antiviral Activity of Chemical Compounds against Influenze Virus. Methodology [in Russian], Leningrad (1977). G. A. Mokrushina, S. K. Kotovskaya, and G. A. Yurchenko, Conference on the Chemistry and Technology of Organic Sulfur Compounds and Sulfur-Containing

  NS Egorov，抗生素科学基础 [俄文]，第 3 版，莫斯科（1979 年），第 46-47 页~ VI ll'enko，化合物抗流感病毒抗病毒活性的测试和评估方法。方法论[俄语]，列宁格勒（1977 年）。GA Mokrushina、SK Kotovskaya 和 GA Yurchenko，有机硫化合物和含硫石油化学与技术会议。第 16 号：论文摘要 [俄文]，里加，1984 年，第 1 页。187. GA Mokrushina、SK Kotovskaya、GN Tyurenkova 等人，Khim.-farm。Zh., No. 2, 195 (1988).
• Bednyagina,N.P.; Getsova,I.N., Journal of Organic Chemistry USSR (English Translation), 1965, vol. 1, p. 135 - 137
  作者：Bednyagina,N.P.、Getsova,I.N.

  DOI：——

  日期：——