4-fluorophenyldisulfide | 31819-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-fluorophenyldisulfide
• 英文别名: p-Fluorphenylhydrodisulfid；1-(Disulfanyl)-4-fluorobenzene
• CAS: 31819-08-6
• 化学式: C₆H₅FS₂
• 分子量: 160.236
• InChiKey: DWSLRBJSYZCFFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-fluorophenyldisulfide 在 碘 作用下， 以 四氢呋喃 为溶剂， 反应 0.18h， 生成 1-(4-fluorophenyl)-3-(p-tolyl)trisulfane
  参考文献：
  名称：

  Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate

  摘要：

  New methodology is presented for the formation of unsymmetrical organotrisulfides in a high yield and purity, relatively free of polysulfide byproducts. The highlight of the method is the low-temperature (-78 degrees C) deprotection of a disulfanyl acetate with sodium methoxide in THF to form a disulfanyl anion, which reacts rapidly in situ with an organothiosulfonate (S-aryl or S-alkyl) within 30 seconds followed by quenching. The discovery of these new reaction conditions together with the relative greenness of the chemistry overall makes for an efficient protocol, from which a range of organotrisulfides covering aliphatic, aromatic, as well as cysteine and sugar groups can be accessed in a high yield and purity.

  DOI：

  10.1021/acs.joc.8b03262

文献信息

• N-hydroxy-N-[3-[2-(halophenylthio)phenyl]prop-2-enyl]ureas as
  申请人：Eli Lilly and Company

  公开号：US05283361A1

  公开（公告）日：1994-02-01

  This invention relates to N-hydroxy-N-[3-[2-(4'-halophenylthio)phenyl]prop-2-enyl]ureas, formulations containing those compounds and methods of using such compounds as 5-lipoxygenase inhibiting agents.

  本发明涉及N-羟基-N-[3-[2-(4'-卤苯硫基)苯基]丙-2-烯基]脲类化合物，含有这些化合物的配方以及将这些化合物用作5-脂氧合酶抑制剂的方法。
• [EN] 4-PIPERAZINYL BENZENESULFONYL INDOLES WITH 5-HT6 RECEPTOR AFFINITY<br/>[FR] INDOLES 4-PIPERAZINYLE BENZENESULFONYLE PRESENTANT UNE AFFINITE POUR LE RECEPTEUR 5-HT6
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004035047A1

  公开（公告）日：2004-04-29

  This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein; or individual isomer, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

  这项发明涉及一类通常具有5-HT6受体亲和力的化合物，其由式（I）所代表：其中R1、R2、R3、R4和R5如本文所定义；或其各个异构体、消旋体或非消旋体异构体混合物，或其药用可接受的盐或溶剂化合物。该发明还涉及含有这类化合物的药物组合物，以及将其用作治疗剂的方法和其制备方法。
• 4-Piperazinyl benzenesulfonyl indoles and uses thereof
  申请人：——

  公开号：US20040087593A1

  公开（公告）日：2004-05-06

  This invention relates to compounds which have generally 5-HT6 receptor affinity and which are represented by Formula I: 1 wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.

  本发明涉及一种通常具有5-HT6受体亲和力的化合物，其由公式I表示：其中R1、R2、R3、R4和R5如本文所定义；或其单一异构体、外消旋或非外消旋异构体混合物，或其药学上可接受的盐或溶剂化物。本发明还涉及包含这些化合物的制药组合物，它们作为治疗剂的使用方法，以及它们的制备方法。
• Antiviral agent
  申请人：——

  公开号：US20040229909A1

  公开（公告）日：2004-11-18

  The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. 1 (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH; R A is a group shown by 2 (wherein, C ring is N-containing aromatic heterocycle) or the like)

  本发明提供了一种整合酶抑制剂。发明人发现以下化合物具有整合酶抑制活性，其化学式为(I)。其中，RC和RD与相邻的碳原子一起形成一个环，该环可以是一个缩合环，Y是羟基，巯基或氨基; Z是O，S或NH; RA是由2所示的基团（其中，C环是含N的芳香杂环）或类似基团。
• Carbapenem derivatives and antimicrobial agents comprising the same
  申请人：SUNTORY LIMITED

  公开号：EP0826687A1

  公开（公告）日：1998-03-04

  Carbapenem derivatives represented by the following Formula I, wherein R1 represents hydrogen, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic, R2 represents hydrogen or a protective group for carboxyl, and R3 represents methyl or ethyl; and pharmaceutically acceptable salts thereof are antimicrobial agents effective against, inter alia, methicillin-resistant Staphylococcus aureus. The analogous compounds in which (a) R1 is a substituted or unsubstituted alkyl, alkenyl, aralkyl or acyl group, R2 is a carboxyl-protecting group or or (b) R1 is a substituted or unsubstituted alkyl, alkenyl, aralkyl, aryl, heterocyclic or acyl group, R2 is a carboxyl-protecting group and the hydroxyl group is protected are novel process intermediates.

  由下式 I 代表的碳青霉烯类衍生物、 其中 R1 代表氢、取代或未取代的芳基或取代或未取代的杂环基，R2 代表氢或羧基保护基团，R3 代表甲基或乙基；及其药学上可接受的盐类是对耐甲氧西林金黄色葡萄球菌等有效的抗菌剂。(a) R1 是取代或未取代的烷基、烯基、芳烷基或酰基，R2 是羧基保护基团，或 (b) R1 是取代或未取代的烷基、烯基、芳烷基、芳基、杂环基或酰基，R2 是羧基保护基团且羟基受到保护的类似化合物是新型工艺中间体。