5-amino-N,N-dimethylnaphthalene-1-sulfonamide | 147752-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-amino-N,N-dimethylnaphthalene-1-sulfonamide
• 英文别名: 1-Naphthalenesulfonamide, 5-amino-N,N-dimethyl-
• CAS: 147752-43-0
• 化学式: C₁₂H₁₄N₂O₂S
• 分子量: 250.321
• InChiKey: SFCKJSUFEKYJJP-UHFFFAOYSA-N

物化性质

• 沸点：
  452.6±37.0 °C(Predicted)
• 密度：
  1.308±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-amino-N,N-dimethylnaphthalene-1-sulfonamide 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 26.0h， 生成 5-[[(2E,6E)-8-hydroxy-2,6-dimethylocta-2,6-dienyl]amino]-N,N-dimethylnaphthalene-1-sulfonamide
  参考文献：
  名称：

  Synthesis and Activity of Fluorescent Isoprenoid Pyrophosphate Analogues

  摘要：

  New fluorescent analogues of farnesol and geranylgeraniol have been prepared and then converted to the corresponding pyrophosphates. These analogues incorporate anthranylate or dansyl-like groups anchored to the terpenoid skeleton through amine bonds that would be expected to be relatively stable to metabolism. After addition of the alcohols or the pyrophosphates to the culture medium, their fluorescence is readily observed inside a human-derived leukemia cell line. Enzyme assays have revealed that the farnesyl pyrophosphate analogue is an inhibitor of FTase, while the corresponding alcohol is not. These results, together with Western blot analyses of cell lysates, indicate that the farnesyl pyrophosphate analogue penetrates the cells as an intact pyrophosphate and that it does so at a biologically relevant concentration.

  DOI：

  10.1021/jo049101w
• 作为产物：
  描述：

  5-乙酰氨基萘-1-磺酰氯 在 甲醇 、 N,N-二异丙基乙胺 、 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 5-amino-N,N-dimethylnaphthalene-1-sulfonamide
  参考文献：
  名称：

  WO2021050992A5

  摘要：

  公开号：

  WO2021050992A5

文献信息

• Dynamic Covalent Switches and Communicating Networks for Tunable Multicolor Luminescent Systems and Vapor-Responsive Materials
  作者：Hanxun Zou、Yu Hai、Hebo Ye、Lei You

  DOI：10.1021/jacs.9b07175

  日期：2019.10.16

  recyclable multi-responsive luminescent materials were achieved with molecular networks on the solid support, allowing visualization of different types of vapors and quantification of primary amine vapors with high sensitivity and wide detection range. The results reported herein should be appealing to future studies of dynamic assemblies, molecular sensing, intelligent materials, and biological labeling

  分子开关是一个密集的研究领域，尤其是多态开关的控制具有挑战性。在这里，我们介绍了动态共价开关和通信网络的通用和通用策略，其中可逆共价系统的不同状态可以诱导可寻址的荧光切换。分子内环/链平衡的调节、与胺的分子间动态共价反应 (DCR) 以及两者都允许激活光开关。荧光团和 2-甲酰基苯磺酰基单元之间吸电子竞争的变化提供了不同的信号模式。通过对复杂混合物中 DCR 的精细控制，原位开关的组合进一步支持创建用于多状态颜色切换的通信网络，包括白光发射。最后，通过固体载体上的分子网络实现了可逆和可回收的多响应发光材料，允许以高灵敏度和宽检测范围对不同类型的蒸汽进行可视化和伯胺蒸汽的量化。本文报告的结果应该对动态组装、分子传感、智能材料和生物标记的未来研究具有吸引力。
• USP30 INHIBITORS AND USES THEREOF
  申请人：Vincere Biosciences, Inc.

  公开号：EP4028385A1

  公开（公告）日：2022-07-20
• Nitrosation-Inducible Inhibitors Biological Macromolecules
  申请人：NUDLER Evgeny

  公开号：US20090186829A1

  公开（公告）日：2009-07-23

  Biomacromolecules such as proteins are inactivated by hydrophobic ANSA derivatives of the formula: wherein R 1 and R 2 are hydrophobic or affinity groups and R 3 is selected from the group consisting of aminoacyl groups and peptidyl groups upon nitrosation. ANSA derivatives can be designed to selectively kill tumor cells and various pathogens, including bacteria, viruses, and fungi.
• [EN] SYNTHESIS OF PROTEASE SUBSTRATES<br/>[FR] SYNTHESE DE SUBSTRATS A BASE DE PROTEASE
  申请人：CHEMRX ADVANCED TECHNOLOGIES I

  公开号：WO2001010890A2

  公开（公告）日：2001-02-15

  The present invention provides a process for synthesizing a compound or an array of compounds of Formula (I) and Formula (6) wherein peptidal substrates are bound to a solid support and a fluorescent moiety. Also provided is a process for synthesizing compounds of Formula (II) wherein peptidal substrates are bound to a fluorescent moiety. These related processes afford said peptidal substrates having a varied structural order.
• [EN] USP30 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS D'USP30 ET UTILISATIONS DE CEUX-CI
  申请人：VINCERE BIOSCIENCES INC

  公开号：WO2021050992A1

  公开（公告）日：2021-03-18

  The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of USP30, and the treatment of USP30-mediated disorders.