2-甲基-2-苯基-1,3-恶唑烷 | 65687-97-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-甲基-2-苯基-1,3-恶唑烷
• 英文名称: 2-methyl-2-phenyloxazolidine
• 英文别名: 2-phenyl-2-methyloxazolidine；2-methyl-2-phenyl-oxazolidine；Oxazolidine, 2-methyl-2-phenyl-；2-methyl-2-phenyl-1,3-oxazolidine
• CAS: 65687-97-0
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: ZPXMCDDVPLMEFT-UHFFFAOYSA-N

物化性质

• 沸点：
  254.4±28.0 °C(Predicted)
• 密度：
  1.030±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-甲基-2-苯基-1,3-恶唑烷 在 偶氮二异丁腈 、 三丁基氯化锡 、 sodium cyanoborohydride 、 三乙胺 作用下， 以 二氯甲烷 、 叔丁醇 、 苯 为溶剂， 反应 8.5h， 生成 3-(3-benzoyl-2-phenyl-2-methyloxazolidin-4-yl)propionitrile
  参考文献：
  名称：

  A concise method for the functionalisation of ethanolamine α to nitrogen using free radical methodology

  摘要：

  A method is described for the free radical functionalisation of ethanolamine at the carbon atom alpha to nitrogen. The key step of the methodology is a 1,5-hydrogen atom abstraction to produce an alpha-aminoalkyl radical at C-4 of a 1,3-oxazolidine. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01123-6
• 作为产物：
  描述：

  C.I.酸性橙108 、 苯乙酮 以 苯 为溶剂， 反应 24.0h， 生成 2-甲基-2-苯基-1,3-恶唑烷
  参考文献：
  名称：

  A concise method for the functionalisation of ethanolamine α to nitrogen using free radical methodology

  摘要：

  A method is described for the free radical functionalisation of ethanolamine at the carbon atom alpha to nitrogen. The key step of the methodology is a 1,5-hydrogen atom abstraction to produce an alpha-aminoalkyl radical at C-4 of a 1,3-oxazolidine. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(00)01123-6

文献信息

• Reactions of aromatic methyl ketimines with halonitriles as a new route to pyrimidines with two polyhaloalkyl groups
  作者：Vyacheslav Ya Sosnovskikh、Boris I Usachev、Gerd-Volker Röschenthaler

  DOI：10.1016/s0040-4020(01)01231-5

  日期：2002.2

  N-Isopropyl-(1-phenylethylidene)amine reacts with trichloroacetonitrile to give 1-azabutadiene derivative, which undergoes a double addition reaction with a variety of halonitriles affording fluoro- and chloro-containing pyrimidines. Pyrimidines with two poly-haloalkyl groups were obtained by the reaction of methyl ketimines with an excess of trichloroacetonitrile, trifluoroacetonitrile and 2,2,3,3-tetrafluoropropionitrile. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Synthesis of pyrrole N-derivatives from oxazolidines
  作者：E. Kh. Sadykov、V. K. Stankevich、N. A. Lobanova、G. R. Klimenko

  DOI：10.1134/s1070428014020134

  日期：2014.2

  Transformations of oxazolidine derivatives synthesized from industrially produced amino alcohols, aldehydes, and ketones under basic or acidic catalysis lead to the formation of N-alkyl- and N-(hydroxyalkyl)-substituted pyrroles in 19-81% yields.
• Acetylation of oxazolidines with ketene
  作者：L. B. Dashkevich、F. G. Shepel

  DOI：10.1007/bf00469913

  日期：——
• Ring-chain tautomerism in oxazolidines
  作者：Ferenc Fulop、Kalevi Pihlaja、Kari Neuvonen、Gabor Bernath、Gyula Argay、Alajos Kalman

  DOI：10.1021/jo00059a065

  日期：1993.3
• Ye, Fei; Gao, Shuang; Fu, Ying, Indian Journal of Heterocyclic Chemistry, 2012, vol. 21, # 3, p. 277 - 280
  作者：Ye, Fei、Gao, Shuang、Fu, Ying、Wang, Xin-Ming、Xing, Zhi-Yong

  DOI：——

  日期：——