2-chloro-6-(ethylthio)purine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-chloro-6-(ethylthio)purine
• 英文别名: 2-chloro-6-ethylsulfanyl-9H-purine；2-chloro-6-ethylsulfanyl-7H-purine
• 化学式: C₇H₇ClN₄S
• 分子量: 214.678
• InChiKey: WTQRLTKOSKLHNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二氯嘌呤 在 乙硫醇 作用下， 以 四氢呋喃 为溶剂， 生成 2-chloro-6-(ethylthio)purine
  参考文献：
  名称：

  Purine derivatives inhibitors of tyrosine protein kinase SYK

  摘要：

  本文披露了以自由或盐形式呈现的公式化合物，其中X、R1、R2、R3和R4如规范中定义，它们的制备以及它们作为药物的用途，特别用于治疗炎症性或阻塞性呼吸道疾病。

  公开号：

  US06589950B1

文献信息

• [EN] PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK<br/>[FR] INHIBITEURS DE DERIVES DE PURINE DE LA TYROSINE KINASE SYK
  申请人：NOVARTIS AG

  公开号：WO2001009134A1

  公开（公告）日：2001-02-08

  Compounds of formula (I) in free or salt form, where X, R?1, R2, R3 and R4¿ are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of inflammatory or obstructive airways disease.

  公式为（I）的化合物，无论是自由形式还是盐形式，其中X、R1、R2、R3和R4¿的定义如规范所述，它们的制备以及它们作为药物的用途，特别是用于治疗炎症或阻塞性呼吸道疾病。
• Antimycobacterial Agents. 1. Thio Analogues of Purine
  作者：Ashish K. Pathak、Vibha Pathak、Lainne E. Seitz、William J. Suling、Robert C. Reynolds

  DOI：10.1021/jm030389b

  日期：2004.1.1

  Thio analogues of purine, pyridine, and pyrimidine were prepared based on the initial activity screening of several analogues of these heterocycles against Mycobacterium tuberculosis (Mtb). Certain 6-thio-substituted purine analogues described herein showed moderate to good inhibitory activity. In particular, two purine analogues 9-(ethylcarboxymethyl)-6-(decylthio)9H-purine (20) and 9-(ethylcarboxymethyl)-6-(dodecylthio)-9H-purine (21) exhibited MIC values of 1.56 and 0.78 mug/mL respectively against the Mtb H(37)Rv strain. N-9-Substitution apparently enhances the antimycobacterial activity in the purine series described herein.
• PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK
  申请人：Novartis AG

  公开号：EP1200435B1

  公开（公告）日：2003-10-01
• US6589950B1
  申请人：——

  公开号：US6589950B1

  公开（公告）日：2003-07-08
• Purine derivatives inhibitors of tyrosine protein kinase SYK
  申请人：Novartis AG

  公开号：US06589950B1

  公开（公告）日：2003-07-08

  Disclosed are compounds of the formula in free or salt form, wherein X, R1, R2, R3, and R4 are as defined in the specification, their preparation and their use as pharmaceuticals, particularly for the treatment of inflammatory or obstructive airways disease.

  本文披露了以自由或盐形式呈现的公式化合物，其中X、R1、R2、R3和R4如规范中定义，它们的制备以及它们作为药物的用途，特别用于治疗炎症性或阻塞性呼吸道疾病。