2,3-dimethyl-thiobenzamide | 23822-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3-dimethyl-thiobenzamide
• 英文别名: 2,3-Dimethylbenzothioamide；2,3-dimethylbenzenecarbothioamide
• CAS: 23822-11-9
• 化学式: C₉H₁₁NS
• 分子量: 165.259
• InChiKey: QBKPJKJQRZFKFT-UHFFFAOYSA-N

物化性质

• 熔点：
  137-138 °C
• 沸点：
  296.3±50.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2,3-dimethyl-thiobenzamide 在 ammonium cerium (IV) nitrate 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  通过铱催化的CH活化，1,2,4-噻二唑与马来酰亚胺的区域选择性CC交叉偶联。

  摘要：

  开发了通过铱催化的1,2,4-噻二唑与马来酰亚胺的区域选择性CC交叉偶联。这种转化将1,2,4-噻二唑和琥珀酰亚胺策略性地连接在一起，形成的新型分子可能具有潜在的生物活性。

  DOI：

  10.1039/c9ob01539f
• 作为产物：
  描述：

  2,3-二甲基苯腈 在 sodiumsulfide nonahydrate 作用下， 生成 2,3-dimethyl-thiobenzamide
  参考文献：
  名称：

  通过铱催化的CH活化，1,2,4-噻二唑与马来酰亚胺的区域选择性CC交叉偶联。

  摘要：

  开发了通过铱催化的1,2,4-噻二唑与马来酰亚胺的区域选择性CC交叉偶联。这种转化将1,2,4-噻二唑和琥珀酰亚胺策略性地连接在一起，形成的新型分子可能具有潜在的生物活性。

  DOI：

  10.1039/c9ob01539f

文献信息

• HETEROCYCLIC COMPOUND AND p27Kip1 DEGRADATION INHIBITOR
  申请人：Uchida Hiroshi

  公开号：US20130079306A1

  公开（公告）日：2013-03-28

  A novel heterocyclic compound or a salt thereof useful for selectively inhibiting the degradation of p27 Kip1 is provided. The compound or the salt thereof is represented by the following formula (1): wherein A represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group, the group A may have a substituent; the ring B represents a 5- to 8-membered monocyclic heterocyclic ring or a condensed ring containing the monocyclic heterocyclic ring, the ring B may have a substituent; the ring C represents an aromatic ring, the ring C may have a substituent; L represents a linker comprising a main chain having 3 to 5 atoms selected from the group consisting of a carbon atom, a nitrogen atom, an oxygen atom and a sulfur atom, wherein at least one atom in the main chain is a hetero atom selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, the linker L may have a substituent; and n is 0 or 1.

  提供了一种新型杂环化合物或其盐，用于选择性地抑制p27Kip1的降解。该化合物或其盐由以下式（1）表示：其中A代表烷基、环烷基、芳基或杂环基，基团A可能有取代基；环B代表5至8成员的单环杂环环或包含该单环杂环环的缩合环，环B可能有取代基；环C代表芳香环，环C可能有取代基；L代表包含3至5个原子的主链的连接物，所述原子选自碳原子、氮原子、氧原子和硫原子组成的群，其中主链中的至少一个原子是选自氮原子、氧原子和硫原子组成的杂原子，连接物L可能有取代基；n为0或1。
• Fungicides
  申请人：ZENECA LIMITED

  公开号：EP0381330A1

  公开（公告）日：1990-08-08

  Fungicidal compounds of the formula (I): in which A and B are independently H, fluoro, chloro, bromo, C₁₋₄ alkyl, C₁₋₄ alkoxy or halo(C₁₋₄)alkyl provided that both are not H; D and E are independently H or fluoro; R¹ is H, C₁₋₄ alkyl or C₁₋₄ alkoxy; R² is C₁₋₄ alkyl, C₁₋₄ alkoxy or optionally substituted phenyl, or R¹ and R² together with the nitrogen atom to which they are attached join to form a morpholine, piperidine, pyrrolidine or azetidine ring which is optionally substituted with C₁₋₄ alkyl; R³ is H; R⁴ is trichloromethyl, C₂₋₈ alkyl (optionally substituted with halogen, C₁₋₈ alkoxy or R′S(O)n in which R′ is C₁₋₄ alkyl, C₂₋₄ alkenyl or C₂₋₄ alkynyl and n is 0, 1 or 2), cyclopropyl (optionally substituted with halogen or C₁₋₄ alkyl), C₂₋₈ alkenyl, C₂₋₈ alkynyl, C₁₋₈ alkoxy, mono- or di(C₁₋₄)alkyl- amino or the group, R˝ON=C(CN) in which R˝ is C₁₋₄ alkyl, or R³ and R⁴ together with the group C(O)N to which they are attached join to form an azetidin-2-one ring which is optionally substituted with halogen or C₁₋₄ alkyl; and X and Y are independently oxygen or sulphur.

  式 (I) 的杀真菌化合物： 其中 A 和 B 独立地为 H、氟、氯、溴、C₁₋₄ 烷基、C₁₋₄ 烷氧基或卤代(C₁₋₄)烷基，但两者均非 H；D 和 E 独立地为 H 或氟； R¹ 为 H、C₁₋₄ 烷基或 C₁₋₄ 烷氧基；R² 是 C₁₋₄烷基、C₁₋₄烷氧基或任选取代的苯基，或 R¹ 和 R² 与它们连接的氮原子一起形成吗啉环、哌啶环、吡咯烷环或氮杂环丁烷环，该环任选被 C₁₋₄ 烷基取代；R³ 是 H；R⁴是三氯甲基、C₂₋₈烷基（可选择被卤素取代）、C₁₋₈烷氧基或 R′S(O)n，其中 R′是 C₁₋₄烷基、C₂₋₈炔基、C₁₋₈烷氧基、单-或双(C₁₋₄)烷基-氨基或基团 R˝ON=C(CN)，其中 R˝ 是 C₁₋₄ 烷基、或 R³ 和 R⁴ 连同它们所连接的基团 C(O)N 形成一个氮杂环丁-2-酮环，该环可选择被卤素或 C₁₋₄ 烷基取代；X 和 Y 独立地为氧或硫。
• Non-toxic corrosion-protection pigments based on manganese
  申请人：——

  公开号：US20040011252A1

  公开（公告）日：2004-01-22

  Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

  以锰为基础的缓蚀颜料含有三价或四价锰/价稳定剂复合物。一种无机或有机材料可用于稳定三价或四价锰离子，从而形成一种可少量溶解、溶解度低或不溶于水的化合物，具体取决于预期用途。选择特定的稳定剂是为了控制三价锰或四价锰在遇水时的释放率，并调整粉末在所选粘合剂体系中用作颜料时的相容性。稳定剂还可以改变成型粉末的加工和处理特性。锰/价稳定剂组合的选择是基于锰配位化学的基本原理。文中介绍了许多锰价稳定剂组合，其性能与传统的六价铬或四价铅体系相当。需要强调的是，提供本摘要是为了符合要求提供摘要的规则，以便检索者或其他读者快速确定技术公开的主题。提交本摘要的前提是，本摘要不用于解释或限制权利要求的范围或含义。
• Nonsteroidal antiinflammatory agents. 1. 2,4-Diphenylthiazole-5-acetic acid and related compounds
  作者：Kevan Brown、David P. Cater、John F. Cavalla、David Green、Robert A. Newberry、Alan B. Wilson

  DOI：10.1021/jm00257a010

  日期：1974.11
• OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF
  申请人：TREGA BIOSCIENCES, INC.

  公开号：EP1126833A2

  公开（公告）日：2001-08-29