(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(4-ethoxy-4-oxobutyl)aziridine-2-carboxylate | 1338801-13-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(4-ethoxy-4-oxobutyl)aziridine-2-carboxylate
• 英文别名: ethyl (2R,3R)-1-[bis(4-methoxy-3,5-dimethylphenyl)methyl]-3-(4-ethoxy-4-oxobutyl)aziridine-2-carboxylate
• CAS: 1338801-13-0
• 化学式: C₃₀H₄₁NO₆
• 分子量: 511.659
• InChiKey: COPJDIDTZNZZOV-QPLSPKJVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  74.1
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  重氮乙酸乙酯 、 5-氧代戊酸乙酯 、 以 甲苯 为溶剂， 反应 24.0h， 以210 mg的产率得到(2R,3R)-ethyl 1-(bis(4-methoxy-3,5-dimethylphenyl)methyl)-3-(4-ethoxy-4-oxobutyl)aziridine-2-carboxylate
  参考文献：
  名称：

  Multicomponent Catalytic Asymmetric Aziridination of Aldehydes

  摘要：

  The first multicomponent catalytic asymmetric aziridination reaction is developed to give aziridine-2-carboxylic esters with very high diastereo- and enantioselectivity from aromatic and aliphatic aldehydes. This new method pushes the boundary of the aziridination reaction to substrates that failed with preformed imines.

  DOI：

  10.1021/ol202472z

文献信息

• Multicomponent Catalytic Asymmetric Aziridination of Aldehydes
  作者：Anil K. Gupta、Munmun Mukherjee、William D. Wulff

  DOI：10.1021/ol202472z

  日期：2011.11.4

  The first multicomponent catalytic asymmetric aziridination reaction is developed to give aziridine-2-carboxylic esters with very high diastereo- and enantioselectivity from aromatic and aliphatic aldehydes. This new method pushes the boundary of the aziridination reaction to substrates that failed with preformed imines.